KEGG ORTHOLOGY: K06825

ORTHOLOGY: K06825

Entry

K06825                      KO

Symbol

FBN1

Name

fibrillin 1

Pathway

map04350

TGF-beta signaling pathway

map04518

Integrin signaling

map04820

Cytoskeleton in muscle cells

Disease

H00653

Marfan syndrome

H00661

MASS phenotype

H00662

Ectopia lentis

H00673

Weill-Marchesani syndrome

H00900

Geleophysic dysplasia

H01173

Stiff skin syndrome

H02228

Acromicric dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K06825  FBN1; fibrillin 1
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    K06825  FBN1; fibrillin 1
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K06825  FBN1; fibrillin 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K06825  FBN1; fibrillin 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   K06825  FBN1; fibrillin 1

Other DBs

GO:

0030023

Genes

HSA:	2200(FBN1)

PTR:	453411(FBN1)

PPS:	100989810(FBN1)

GGO:	101152856(FBN1)

PON:	100457874(FBN1)

PPYG:

129014023(FBN1)

NLE:	100591311(FBN1)

HMH:	116481758(FBN1)

SSYN:

129482741(FBN1)

MCC:	714451(FBN1)

MCF:	102127300(FBN1)

MTHB:

126958681

MNI:	105490699(FBN1)

CSAB:

103245664(FBN1)

CATY:

105588202(FBN1)

PANU:

101013946(FBN1) 116272788

TGE:	112627472(FBN1)

MLEU:

105529986(FBN1)

RRO:	104657944(FBN1)

RBB:	108530109(FBN1)

TFN:	117070692(FBN1)

PTEH:

111552787(FBN1)

CANG:

105502183(FBN1)

CJC:	100391128(FBN1)

SBQ:	101034956(FBN1)

CIMI:

108315623(FBN1)

ANAN:

105710069(FBN1)

CSYR:

103272392(FBN1)

MMUR:

105870753(FBN1)

LCAT:

123622345(FBN1)

ERUF:

138392957(FBN1)

PCOQ:

105814465(FBN1)

OGA:	100945220(FBN1)

MMU:	14118(Fbn1)

MCAL:

110290244(Fbn1)

MPAH:

110318400(Fbn1)

RNO:	83727(Fbn1)

MCOC:

116090845(Fbn1)

ANU:	117703980(Fbn1)

ASYL:

127685840(Fbn1)

MUN:	110545291(Fbn1)

CGE:	100761283(Fbn1)

MAUA:

101827314(Fbn1)

PROB:

127221522(Fbn1)

PLEU:

114683899(Fbn1)

PMAV:

102927887(Fbn1)

MORG:

121465615(Fbn1)

MFOT:

126496307

AAMP:

119814660(Fbn1)

CNL:	130881082(Fbn1)

NGI:	103733031(Fbn1)

HGL:	101718482(Fbn1)

CPOC:

100717565(Fbn1)

CCAN:

109684261(Fbn1)

DORD:

105981112(Fbn1)

DSP:	122114357(Fbn1)

DMER:

138830167(Fbn1)

PLOP:

125341006(Fbn1)

NCAR:

124976767

SVUL:

306654476(FBN1)

MMMA:

107137627(Fbn1)

ITI:	101960048(Fbn1)

OCU:

100350931

OPI:	101522177(FBN1)

OCZ:	121148729(FBN1)

TUP:

102495054

GVR:	103587218(FBN1)

CFA:	478293(FBN1)

CLUD:

112675962(FBN1)

VVP:	112919888(FBN1)

VLG:	121484376(FBN1)

NPO:	129506238(FBN1)

AML:	100475873(FBN1)

UMR:	103676717(FBN1)

UAH:	113269591(FBN1)

UAR:	123801871(FBN1)

ELK:

111158675

LLV:

125104033

MPUF:

101678848(FBN1)

MNP:	131999734(FBN1)

MLK:	131836250(FBN1)

NVS:	122894037(FBN1)

ORO:	101375148(FBN1)

EJU:	114202600 114202603

ZCA:	113909044(FBN1)

MLX:	118003603(FBN1)

MANO:

123861241(FBN1)

NSU:	110583931(FBN1)

LWW:

102726566

FCA:	101084882(FBN1)

PYU:	121041667(FBN1)

PCOO:

112855304(FBN1)

PBG:	122468675(FBN1)

PVIV:

125167893(FBN1)

LRUF:

124508060

LGF:	123583056(FBN1)

AJU:

106967216

PTG:	102954262(FBN1)

PPAD:

109263021(FBN1)

PUC:

125909979

PLEZ:

122222069(FBN1)

HHV:	120220847(FBN1)

CCRU:

144231861(FBN1)

BTA:	281154(FBN1)

BOM:	102283369(FBN1)

BIU:	109564381(FBN1)

BJV:	133254687(FBN1)

BBUB:

102408080(FBN1)

BKE:	129621502(FBN1)

BBIS:

104988280(FBN1)

CHX:	102180397(FBN1)

OAS:	101109620(FBN1)

OCAN:

138443716(FBN1)

BTAX:

128054422(FBN1)

CSUM:

138072660(FBN1)

ODA:	120852956(FBN1)

CCAD:

122444302(FBN1)

MREE:

136172326(FBN1)

OVR:	110134317(FBN1)

MBEZ:

129563163(FBN1)

SSC:	414836(FBN1)

CFR:	102519605(FBN1)

CBAI:

105077074(FBN1)

CDK:	105104860(FBN1)

VPC:	102539804(FBN1)

BACU:

103000226(FBN1)

BMUS:

118889796(FBN1)

LVE:	103069185(FBN1)

OOR:	101290335(FBN1)

LALB:

132520762(FBN1)

GMF:	115845070(FBN1)

DDP:	132420610(FBN1)

SCOO:

307178647(FBN1)

DLE:	111181619(FBN1)

PCAD:

102990826(FBN1)

PSIU:

116749629(FBN1)

PPHC:

136119436(FBN1)

NASI:

112396512(FBN1)

ECB:	100055741(FBN1)

EPZ:	103560288(FBN1)

EAI:	106838658(FBN1)

MYB:	102240213(FBN1)

MYD:	102767925(FBN1)

MMYO:

118651508(FBN1)

MLF:	102432503(FBN1)

MDT:	132237541(FBN1)

MYUM:

139015583(FBN1)

PKL:	118721649(FBN1)

EFUS:

103287407(FBN1)

POTS:

308235266(FBN1)

MNA:	107535590(FBN1)

DRO:	112311047(FBN1)

SHON:

118992597(FBN1)

AJM:	119057608(FBN1)

PDIC:

114491615(FBN1)

PHAS:

123808096(FBN1)

MMF:	118629799(FBN1)

PPAM:

129064268(FBN1)

HAI:

109394466

RFQ:	117023483(FBN1)

PALE:

102880109(FBN1)

PGIG:

120622675(FBN1)

PVP:	105288810(FBN1)

RAY:	107519960(FBN1)

MJV:	108409610(FBN1)

TOD:	119238595(FBN1)

SARA:

101550076(FBN1)

SFUM:

130043066(FBN1)

SETR:

126020918(FBN1)

LAV:	100675136(FBN1)

TMU:

101355639

ETF:	101656813(FBN1)

DNM:	101413828(FBN1)

MDO:	100025769(FBN1)

GAS:	123234107(FBN1)

SHR:	100926696(FBN1)

AFZ:

127551136

PCW:	110201328(FBN1)

TVP:	118828209(FBN1)

PBRV:

138168964(FBN1)

MLAO:

141521810(FBN1)

OAA:	100078497(FBN1)

TACU:

119931769(FBN1)

GGA:	373992(FBN1)

PCOC:

116225312(FBN1)

MGP:	723984(FBN1)

CJO:	107318754(FBN1)

TPAI:

128075308(FBN1)

LMUT:

125698394(FBN1)

NMEL:

110403688(FBN1)

APLA:

101798014(FBN1)

AACU:

137862844(FBN1)

OJA:	118171971(FBN1)

ACYG:

106033778(FBN1)

CATA:

118251561(FBN1)

AFUL:

116493741(FBN1)

TGU:	100225445(FBN1)

LSR:	110474243(FBN1)

VMC:	128813226(FBN1)

VCHA:

128794543(FBN1)

AIB:	137481919(FBN1)

SCAN:

103816018(FBN1)

PMOA:

120509060(FBN1)

OTC:	121343426(FBN1)

PRUF:

121354417(FBN1)

ATRC:

139596860(FBN1)

MATE:

118690659(FBN1)

MAEN:

136561952(FBN1)

GFR:	102037814(FBN1)

FAB:	101817289(FBN1)

OMA:	130257400(FBN1)

PHI:	102102996(FBN1)

PMAJ:

107209390(FBN1)

CCAE:

111934114(FBN1)

CCW:	104683993(FBN1)

CBRC:

103621258

ACOE:

138116256(FBN1)

ETL:	114059922(FBN1)

ZAB:	102066951(FBN1)

ZLE:	135452043(FBN1)

ACHL:

103797870(FBN1)

SVG:	106851825(FBN1)

MMEA:

130575769(FBN1)

HRT:	120758569(FBN1)

SATI:

136367054(FBN1)

CFAI:

136297057(FBN1)

CCIC:

134049374(FBN1)

NNT:	104410070(FBN1)

SHAB:

115612828(FBN1)

FPG:	101922039(FBN1)

FCH:

102056711

FRS:	119151341(FBN1)

CCRI:

104159675(FBN1)

ACUN:

113483885

ANOC:

141965739(FBN1)

SURA:

141948196(FBN1)

TALA:

104357485(FBN1)

ACHC:

115341559(FBN1)

HALD:

104322582(FBN1)

HLE:	104834498(FBN1)

AGEN:

126043698

HHAR:

128151550(FBN1)

BBUT:

142039070(FBN1)

GCL:

127020844

LDI:	104352122(FBN1)

MNB:	103775755(FBN1)

DPUB:

104297330(FBN1)

PPUS:

135182971(FBN1)

IIN:	128972117(FBN1)

AVIT:

104272314(FBN1)

BRHI:

104501478(FBN1)

EGZ:	104130917(FBN1)

NNI:	104017131(FBN1)

PCRI:

104030527(FBN1)

PARX:

142060331(FBN1)

PADL:

103922750(FBN1)

AFOR:

103896619(FBN1)

CBOR:

142086709(FBN1)

GSTE:

104258953(FBN1)

CBOY:

140655722(FBN1)

MAME:

142411712(FBN1)

CLV:	102089012(FBN1)

CNIC:

135992668(FBN1)

PGUU:

104462251

PLET:

104620152(FBN1)

EHS:

104515778

CMAC:

104487129(FBN1)

CUCA:

104055728(FBN1)

PCUR:

138725759(FBN1)

TEO:	104381103(FBN1)

BREG:

104637964(FBN1)

GAME:

129210758(FBN1)

OHA:	104334594(FBN1)

ACAR:

104523486

CEUR:

306719347(FBN1)

CPEA:

104385929(FBN1)

CVF:	104287432(FBN1)

RTD:	128914778(FBN1)

CRID:

134520442(FBN1)

LMIC:

141748270(FBN1)

NARQ:

141470003(FBN1)

AAM:	106496465(FBN1)

AROW:

112963455(FBN1)

NPD:	112952771(FBN1)

TGT:	104569529(FBN1)

DNE:	112981418(FBN1)

SCAM:

104148260(FBN1)

ASN:	102384119(FBN1)

AMJ:	102570392(FBN1)

CPOO:

109309040(FBN1)

GGN:	109288316(FBN1)

PSS:	102455843(FBN1)

CIZ:	142019844(FBN1)

CMY:	102947546(FBN1)

CCAY:

125644191(FBN1)

LKP:	140894946(FBN1)

NDS:	141995281(FBN1)

DCC:	119862351(FBN1)

CPIC:

101947323(FBN1)

TST:	117883712(FBN1)

EOB:	135884771(FBN1)

CABI:

116814941(FBN1)

MRV:	120373044(FBN1)

EMQ:	137158161(FBN1)

ACS:	100556865(fbn1)

ASAO:

132762721(FBN1)

PVT:	110077221(FBN1)

SUND:

121934440(FBN1)

PBI:

103048648

PMUR:

107287690(FBN1)

CTIG:

120315152(FBN1)

PGUT:

117675753(FBN1)

PCAE:

139324166(FBN1)

APRI:

131184524

PTEX:

113442165(FBN1)

NSS:	113418295(FBN1)

VKO:	123027703(FBN1)

PMUA:

114584083(FBN1)

PRAF:

128402139(FBN1)

ZVI:	118093304(FBN1)

HCG:	128334769(FBN1)

GJA:	107110932(FBN1)

EMC:	129345208(FBN1)

XLA:	108711397(fbn1.L) 108712909(fbn1.S)

XTR:	100490545(fbn1)

NPR:	108792195(FBN1)

RTEM:

120931330(FBN1)

ACAT:

141133908(FBN1)

PADS:

140322545(FBN1)

BBUF:

120985829(FBN1)

BGAR:

122927624(FBN1)

DTC:	141084059(FBN1)

HSQ:	130368508(FBN1)

PCOB:

134932033(FBN1)

PWL:	138284082(FBN1)

MUO:	115459755(FBN1)

GSH:	117348055(FBN1)

DRE:	100330961(fbn1)

SRX:	107713176 107740798

SANH:

107681008(fbn1) 107698881

SGH:

107595388

CCAR:

109050884 109065748

CAUA:

113061354 113118042(fbn1)

CGIB:

127934339 127977020

PTET:

122362825(fbn1)

LROH:

127180496(fbn1)

GRF:	141345409 141345414(fbn1)

OMC:	131524319(fbn1)

PPRM:

120487759(fbn1)

RKG:

130077531

SCEP:

307160047(fbn1)

MAMB:

125253812(fbn1)

CIDE:

127499672

CERY:

137023500(fbn1)

MASI:

127417196 127455817

TROS:

130562525(fbn1)

TDW:	130435484(fbn1)

MANU:

129419782(fbn1)

PDAB:

135739867(fbn1)

IPU:

124626746

PHYP:

113525464

SMEO:

124395627(fbn1)

TFD:	113664003(fbn1)

TVC:	132851542(fbn1)

CGAR:

128527816(fbn1)

NGRA:

132888235(fbn1)

TRN:	134323243(fbn1)

AMEX:

103046542(fbn1)

CMAO:

118803998(fbn1)

EEE:	113585344(fbn1)

CHAR:

105889114(fbn1)

SPIL:

134095231(fbn1)

ASAD:

121681707(fbn1)

TRU:	101062331(fbn1)

TFS:	130521893(fbn1)

TNG:	GSTEN00018079G001

NCC:

104944153

TBEN:

117471319(fbn1)

CGOB:

115006498(fbn1)

PGEO:

117464960(fbn1)

GACU:

117549257(fbn1)

EMAC:

134863135(fbn1)

ELY:	117264531(fbn1)

EFO:	125898867(fbn1)

PLEP:

121947108(fbn1)

SLUC:

116054710(fbn1)

SVIT:

144536378(fbn1)

ECRA:

117949547(fbn1)

ESP:	116701460(fbn1)

PFLV:

114556576(fbn1)

PFLT:

120555787(fbn1)

GAT:	120812131(fbn1)

PPUG:

119228055(fbn1)

AFB:	129106748(fbn1)

CLUM:

117725420(fbn1)

CANA:

137781403(fbn1)

CVE:	137888783(fbn1)

AMIR:

142934254(fbn1)

MSAM:

119890205(fbn1)

SCHU:

122873599(fbn1)

EARM:

139282428(fbn1)

CUD:	121514318(fbn1)

SPUL:

138593695(fbn1)

LMIX:

132966719(fbn1)

HTC:	141787526(fbn1)

ALAT:

119017535(fbn1)

ASTR:

137594192(fbn1)

PKLU:

139206252(fbn1)

LCO:	104920312(fbn1)

MZE:	101473881(fbn1)

ONL:	100701590(fbn1)

OAU:	116311646(fbn1)

OLA:	101171649(fbn1)

OML:	112160628(fbn1)

CSAI:

133459775(fbn1)

XMA:	102222084(fbn1)

XCO:	114142632(fbn1)

XHE:	116718258(fbn1)

PRET:

103462080(fbn1)

PFOR:

103146151(fbn1)

PLAI:

106935171

PMEI:

106903740(fbn1)

GAF:	122841434(fbn1)

PPRL:

129369448(fbn1)

CVG:	107085343(fbn1)

CTUL:

119782428(fbn1)

GMU:	124866793(fbn1)

NFU:	107381722(fbn1)

KMR:	108250681(fbn1)

ALIM:

106530372

NWH:	119429491(fbn1)

LTU:	140302134(fbn1)

MCEP:

125005079(fbn1)

AOCE:

111565734(fbn1)

EJA:	138212961(fbn1)

BFRE:

138625039(fbn1)

LCF:

108887902

CSEM:

103378839(fbn1)

POV:	109637254(fbn1)

SSEN:

122771917(fbn1)

SSOE:

131459774(fbn1)

HHIP:

117754571(fbn1)

HSP:	118112496(fbn1)

PPLT:

128457609(fbn1)

SMAU:

118302262(fbn1)

SDU:	111238693(fbn1)

SLAL:

111661147(fbn1)

XGL:	120788044(fbn1)

HCQ:	109525877(fbn1)

SSCV:

125967570(fbn1)

SBIA:

133497686(fbn1)

PEE:	133399346(fbn1)

PTAO:

133467102(fbn1)

BPEC:

110172925(fbn1)

ENY:	140381563(fbn1)

MALB:

109963340(fbn1)

BSPL:

114842852(fbn1)

SJO:	128362523(fbn1)

SSCO:

133985156(fbn1)

TTY:	137179748(fbn1)

GMH:	115559058(fbn1)

OTW:

112240592

OMY:	110516722 110526764

OGO:	124020945 124033458(fbn1)

OKI:

109884996

OKE:	118381419(fbn1)

OMM:	135537029 135537031

OCLA:

139403843 139403872

SFON:

129845847

CCLU:

121579719(fbn1)

ELS:	105022664(fbn1)

OEP:

134028285

SFM:	108940859 108942003

PKI:	111845071 111846701

AANG:

118215399 118227283

AROT:

135242761 135255386

CCOG:

133110992 133130179

LOC:	102684788(fbn1)

PSPA:

121294500 121299380

ARUT:

117428027 117429415(fbn1)

PSEX:

120540544(fbn1)

LCM:	102349374(FBN1)

CMK:

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

CIN:	100178466 100182571

SCLV:

120345319 120348319

LVG:	121421812 121421815

AJJ:

139971469

SKO:	100374579 102806860

PFLL:

139128425

ALUD:

128861337

CVJ:	135955065(frac)

ACOZ:

AAG:

ASUA:

CPII:

CBRI:

LLL:

PPAP:

TCA:

TMOL:

ESIM:

EFOR:

RFG:

ATD:

DVV:

NVL:

AME:

ACER:

ALAB:

AFLR:

BIM:

BHUN:

BTER:

FVI:

CCAL:

OBB:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:

TAME:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:	105283233 105286727

PCF:

VVE:

NVI:

CSOL:

NVG:

PHU:	Phum_PHUM426360

ZNE:

PAME:

BROR:

HAMR:

FCD:

DPX:	DAPPUDRAFT_303147

EAF:

SPRM:

MNZ:

MRJ:

PORN:

DALB:

CSCU:

CVS:

PCAN:

BGT:

RPHI:

OBI:

LJP:

NVE:

EPA:

AMIL:

PDAM:

113666405 113666413 113666414 113666415

SPIS:

111331726 111331727 111331763

DGT:

114523099

HMG:	100201520(LOC100201520) 105845628(LOC105845628)

AQU:	100631495 100633339 100640895 105315070 109588004

CCLM:

134188683

SRE:	PTSG_00614

» show all

Reference

PMID:7691719

Authors

Corson GM, Chalberg SC, Dietz HC, Charbonneau NL, Sakai LY

Title

Fibrillin binds calcium and is coded by cDNAs that reveal a multidomain structure and alternatively spliced exons at the 5' end.

Journal

Genomics 17:476-84 (1993)
DOI:10.1006/geno.1993.1350

Sequence

[hsa:2200]

LinkDB

DBGET integrated database retrieval system