KEGG ORTHOLOGY: K19410

ORTHOLOGY: K19410

Entry

K19410                      KO

Symbol

LEMD3

Name

inner nuclear membrane protein Man1

Pathway

map04350

TGF-beta signaling pathway

Disease

H00452

Buschke-Ollendorff syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K19410  LEMD3; inner nuclear membrane protein Man1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K19410  LEMD3; inner nuclear membrane protein Man1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    K19410  LEMD3; inner nuclear membrane protein Man1

Genes

HSA:	23592(LEMD3)

PTR:	452050(LEMD3)

PPS:	100987720(LEMD3)

GGO:	101141096(LEMD3)

PON:	100441107(LEMD3)

PPYG:

129009344(LEMD3)

NLE:	100584007(LEMD3)

HMH:	116478960(LEMD3)

SSYN:

129459350(LEMD3)

MCC:	717597(LEMD3)

MCF:	101866637(LEMD3)

MTHB:

126930995

MNI:	105473449(LEMD3)

CSAB:

103238651(LEMD3)

CATY:

105600530(LEMD3)

PANU:

101002396(LEMD3)

TGE:	112635415(LEMD3)

MLEU:

105537087(LEMD3)

RRO:	104680821(LEMD3)

RBB:	108529349(LEMD3)

TFN:	117089808(LEMD3)

PTEH:

111551248(LEMD3)

CANG:

105502631(LEMD3)

CJC:	100402143(LEMD3)

SBQ:	101047037(LEMD3)

CIMI:

108288393(LEMD3)

ANAN:

105712017(LEMD3)

CSYR:

103273090(LEMD3)

MMUR:

105880973(LEMD3)

LCAT:

123639554(LEMD3)

ERUF:

138396392(LEMD3)

PCOQ:

105824185(LEMD3)

MMU:	380664(Lemd3)

MCAL:

110303868(Lemd3)

MPAH:

110326392(Lemd3)

RNO:	680066(Lemd3)

MCOC:

116076192(Lemd3)

ANU:	117696643(Lemd3)

ASYL:

127671335(Lemd3)

MUN:	110557683(Lemd3)

CGE:	100770973(Lemd3)

MAUA:

101828748(Lemd3)

PROB:

127215708(Lemd3)

PLEU:

114693298(Lemd3)

PMAV:

102927073(Lemd3)

MORG:

121460277(Lemd3)

MFOT:

126515671

AAMP:

119803519(Lemd3)

CNL:	130866506(Lemd3)

NGI:	103730777(Lemd3)

HGL:	106007541(Lemd3)

CPOC:

100730293(Lemd3)

CCAN:

109678571(Lemd3)

DORD:

105989841(Lemd3)

DSP:	122124124(Lemd3)

DMER:

138803898(Lemd3)

PLOP:

125361659(Lemd3)

NCAR:

124982500

MMMA:

107140085(Lemd3)

ITI:	101975604(Lemd3)

OCU:

100346960

OPI:	101525176(LEMD3)

OCZ:	121157921(LEMD3)

TUP:	102477990(LEMD3)

GVR:	103600214(LEMD3)

CFA:	608380(LEMD3)

CLUD:

112677907(LEMD3)

VVP:	112922201(LEMD3)

VLG:	121491019(LEMD3)

NPO:	129511723(LEMD3)

AML:	100484864(LEMD3)

UMR:	103656960(LEMD3)

UAH:	113255861(LEMD3)

UAR:	123787164(LEMD3)

ELK:	111142011 111142142

LLV:

125107422

MPUF:

101674999(LEMD3)

MNP:	132019453(LEMD3)

MLK:	131839108(LEMD3)

NVS:	122892177(LEMD3)

ORO:	101386465(LEMD3)

EJU:	114214941(LEMD3)

ZCA:	113922678(LEMD3)

MLX:	118008614(LEMD3)

NSU:	110570577(LEMD3)

LWW:	102745946(LEMD3)

FCA:	101092198(LEMD3)

PYU:	121040808(LEMD3)

PCOO:

112863663(LEMD3)

PBG:	122472941(LEMD3)

PVIV:

125170145(LEMD3)

LRUF:

124501545

LGF:	123591087(LEMD3)

AJU:

106981329

PTG:	102952157(LEMD3)

PPAD:

109270443(LEMD3)

PUC:

125919305

PLEZ:

122224789(LEMD3)

HHV:	120233170(LEMD3)

BTA:	530659(LEMD3)

BOM:	102268038(LEMD3)

BIU:	109558405(LEMD3)

BBUB:

102394183(LEMD3)

BKE:	129650989(LEMD3)

BBIS:

104989791(LEMD3)

CHX:	102187566(LEMD3)

OAS:	101116043(LEMD3)

BTAX:

128047871(LEMD3)

CSUM:

138078339(LEMD3)

ODA:	120857695(LEMD3)

CCAD:

122427098(LEMD3)

MREE:

136167247(LEMD3)

OVR:	110132148(LEMD3)

MBEZ:

129535634(LEMD3)

SSC:	100511508(LEMD3)

CFR:	102522506(LEMD3)

CBAI:

105081353(LEMD3)

CDK:	105101100(LEMD3)

VPC:	102531382(LEMD3)

BACU:

103014925(LEMD3)

BMUS:

118902019(LEMD3)

LVE:	103083531(LEMD3)

OOR:	101270472(LEMD3)

LALB:

132529243(LEMD3)

GMF:	115858498(LEMD3)

DDP:	132433860(LEMD3)

DLE:	111173783(LEMD3)

PCAD:

102984657(LEMD3)

PSIU:

116760053(LEMD3)

PPHC:

136130957(LEMD3)

NASI:

112394103(LEMD3)

ECB:	100057180(LEMD3)

EPZ:	103560739(LEMD3)

EAI:	106829473(LEMD3)

MYB:	102243653(LEMD3)

MYD:	102770789(LEMD3)

MMYO:

118650103(LEMD3)

MLF:	102429521(LEMD3)

MDT:	132227875(LEMD3)

MYUM:

139006941(LEMD3)

PKL:	118730779(LEMD3)

EFUS:

103292564

MNA:	107527069(LEMD3)

DRO:	112318970(LEMD3)

SHON:

118998730(LEMD3)

AJM:	119042303(LEMD3)

PDIC:

114512704(LEMD3)

PHAS:

123812797(LEMD3)

MMF:	118623032(LEMD3)

PPAM:

129075852(LEMD3)

HAI:	109381701(LEMD3)

RFQ:	117028995(LEMD3)

PALE:

102880385(LEMD3)

PGIG:

120605022(LEMD3)

PVP:	105301182(LEMD3)

RAY:	107508228(LEMD3)

MJV:	108397992(LEMD3)

TOD:	119247545(LEMD3)

SARA:

101538864(LEMD3)

SFUM:

130038943(LEMD3)

SETR:

126022177(LEMD3)

LAV:	100666895(LEMD3)

TMU:

101344398

ETF:	101647819(LEMD3)

DNM:	101421742(LEMD3)

GAS:	123249659(LEMD3)

SHR:	100915523(LEMD3)

AFZ:

127539476

PCW:	110211024(LEMD3)

TVP:	118851663(LEMD3)

PBRV:

138155607(LEMD3)

OAA:	100079476(LEMD3)

TACU:

119936923(LEMD3)

GGA:	417832(LEMD3)

PCOC:

116226610(LEMD3)

MGP:	100545510(LEMD3)

CJO:	107310187(LEMD3)

TPAI:

128073950(LEMD3)

LMUT:

125692915(LEMD3)

NMEL:

110392756(LEMD3)

APLA:

101791115(LEMD3)

AACU:

137849556(LEMD3)

ACYG:

106045428(LEMD3)

CATA:

118246789(LEMD3)

AFUL:

116494674(LEMD3)

TGU:	100220793(LEMD3)

LSR:	110479875(LEMD3)

SCAN:

103820432(LEMD3)

PMOA:

120499814(LEMD3)

OTC:	121339480(LEMD3)

PRUF:

121352529(LEMD3)

ATRC:

139588311(LEMD3)

GFR:	102038551(LEMD3)

FAB:	101809169(LEMD3)

OMA:	130267046(LEMD3)

PHI:	102113048(LEMD3)

PMAJ:

107204846(LEMD3)

CCAE:

111945072(LEMD3)

CCW:	104698464(LEMD3)

CBRC:

103614879(LEMD3)

ACOE:

138100706(LEMD3)

ETL:	114057898(LEMD3) 114069251

ZAB:	102062156(LEMD3)

ZLE:	135442268(LEMD3)

ACHL:

103806979(LEMD3)

SVG:	106860655(LEMD3)

MMEA:

130579982(LEMD3)

HRT:	120751888(LEMD3)

SATI:

136361303(LEMD3)

CFAI:

136289415(LEMD3)

CCIC:

134043544(LEMD3)

FPG:	101920443(LEMD3)

FCH:	102052673(LEMD3)

CCRI:

104166449(LEMD3)

NNT:	104399635(LEMD3)

SHAB:

115605018(LEMD3)

ACUN:

113489466(LEMD3)

SURA:

141944242(LEMD3)

TALA:

104361940(LEMD3)

ACHC:

115336153(LEMD3)

HLE:	104828320(LEMD3)

AGEN:

126034455

HHAR:

128135407(LEMD3)

BBUT:

142045094(LEMD3)

GCL:

127022793

CSTI:

104562320(LEMD3)

MNB:	103780379(LEMD3)

DPUB:

104301123(LEMD3)

PPUS:

135174638(LEMD3)

BRHI:

104498162(LEMD3)

EGZ:	104122210(LEMD3)

NNI:	104011050(LEMD3)

PCRI:

104027378(LEMD3)

PADL:

103920045(LEMD3)

AFOR:

103900439(LEMD3)

CBOR:

142081845(LEMD3)

GSTE:

104258099(LEMD3)

CBOY:

140652378(LEMD3)

MAME:

142406329(LEMD3)

CLV:	102086386(LEMD3)

CNIC:

135988515(LEMD3)

PGUU:

104468796(LEMD3)

PLET:

104619010(LEMD3)

EHS:	104513006(LEMD3)

CMAC:

104485631(LEMD3)

CUCA:

104061549(LEMD3)

BREG:

104638451(LEMD3)

GAME:

129209915(LEMD3)

OHA:	104326814(LEMD3)

CPEA:

104388848(LEMD3)

CVF:	104288957(LEMD3)

RTD:	128905438(LEMD3)

CRID:

134510123(LEMD3)

LMIC:

141737556(LEMD3)

NARQ:

141479123(LEMD3)

AAM:	106488147(LEMD3)

AROW:

112968136(LEMD3)

NPD:	112958835(LEMD3)

TGT:	104574962(LEMD3)

DNE:	112978720(LEMD3)

SCAM:

104142072(LEMD3)

ASN:	102373472(LEMD3)

AMJ:	102561807(LEMD3)

CPOO:

109315978(LEMD3)

GGN:	109296365(LEMD3)

PSS:	102460282(LEMD3)

CIZ:	142023037(LEMD3)

CMY:	102936760(LEMD3)

CCAY:

125630241(LEMD3)

LKP:	140905148(LEMD3)

NDS:	141980660(LEMD3)

DCC:	119856843(LEMD3)

CPIC:

101950904(LEMD3)

TST:	117877542(LEMD3)

CABI:

116821816(LEMD3)

MRV:	120383760(LEMD3)

ACS:	100553511(lemd3)

ASAO:

132776189(LEMD3)

PVT:	110075118(LEMD3)

SUND:

121931307(LEMD3)

PBI:	103063364(LEMD3)

PMUR:

107291831(LEMD3)

CTIG:

120315004(LEMD3)

TSR:	106538397(LEMD3)

PGUT:

117655746(LEMD3)

PCAE:

139319495(LEMD3)

APRI:

131201769(LEMD3)

PTEX:

113435921(LEMD3)

NSS:	113412276(LEMD3)

VKO:	123019846(LEMD3)

PMUA:

114605078(LEMD3)

PRAF:

128421858(LEMD3)

ZVI:	118090649(LEMD3)

HCG:	128326890(LEMD3)

GJA:	107115438(LEMD3)

STOW:

125434806(LEMD3)

EMC:	129335998(LEMD3)

XLA:	108711076(lemd3.L) 398582(lemd3.S)

XTR:	100038042(lemd3)

NPR:	108799435(LEMD3)

RTEM:

120932012(LEMD3)

ACAT:

141132095(LEMD3)

PADS:

140323894(LEMD3)

BBUF:

120980272(LEMD3)

BGAR:

122928032(LEMD3)

DTC:	141059178(LEMD3)

MUO:	115479160(LEMD3)

GSH:	117366734(LEMD3)

DRE:	558474(lemd3)

SRX:	107725595 107757270(lemd3)

SANH:

107655547 107694277

SGH:	107561125(lemd3) 107587170

CCAR:

109066711 109108431

CAUA:

113048355 113060559 113064111 113078226 113094879

CGIB:

127956538 127975945

PTET:

122342223(lemd3)

LROH:

127164370(lemd3)

GRF:	141332787 141333117(lemd3)

OMC:	131539175(lemd3)

PPRM:

120476905(lemd3)

RKG:	130089893(lemd3)

MAMB:

125245680(lemd3)

CERY:

137024375(lemd3)

MASI:

127434960 127436946

TROS:

130548146(lemd3)

TDW:	130421189(lemd3)

MANU:

129431667(lemd3)

PDAB:

135774984(lemd3)

IPU:

108279768

IFU:	128623083(lemd3)

PHYP:

113532174(lemd3)

SMEO:

124400921(lemd3)

TFD:	113645754(lemd3)

TVC:	132858676(lemd3)

CGAR:

128534570(lemd3)

NGRA:

132869815(lemd3)

TRN:	134315006(lemd3)

AMEX:

103030525(lemd3)

CMAO:

118812496(lemd3)

EEE:	113572549(lemd3)

CHAR:

105896962(lemd3)

SPIL:

134062618(lemd3)

ASAD:

121696845(lemd3)

TRU:	101066514(lemd3)

TFS:	130518911(lemd3)

LCO:	104939118(lemd3)

NCC:	104964688 104965304(lemd3)

TBEN:

117483143(lemd3)

CGOB:

115028419(lemd3)

PGEO:

117468314(lemd3)

GACU:

117547163(lemd3)

EMAC:

134879290(lemd3)

ELY:	117249360(lemd3)

EFO:	125882987(lemd3)

PLEP:

121961635(lemd3) 121963255

SLUC:

116042092(lemd3)

ECRA:

117938521(lemd3)

ESP:	116673395(lemd3)

PFLV:

114550221(lemd3)

GAT:	120818444(lemd3)

PPUG:

119210964(lemd3)

AFB:	129112663(lemd3)

CLUM:

117726046(lemd3)

PSWI:

130200477(lemd3)

CANA:

137791477(lemd3)

CVE:	137877307(lemd3)

MSAM:

119918323 119918553

SCHU:

122871153(lemd3)

EARM:

139305242(lemd3)

CUD:	121505450(lemd3)

SPUL:

138599660(lemd3)

LMIX:

132956280(lemd3)

HTC:	141810479(lemd3)

ALAT:

119032155(lemd3)

ASTR:

137589162(lemd3)

PKLU:

139221987(lemd3)

MZE:	101484863(lemd3)

ONL:	100703028(lemd3)

OAU:	116332105(lemd3)

OLA:	101162412(lemd3)

OML:	112140052(lemd3)

XMA:	102233606(lemd3)

XCO:	114160629(lemd3)

XHE:	116736423(lemd3)

PRET:

103459738(lemd3)

PFOR:

103129863

PLAI:

106959754(lemd3)

PMEI:

106908752(lemd3)

GAF:	122826094(lemd3)

PPRL:

129376183(lemd3)

CVG:	107094277(lemd3)

CTUL:

119778764(lemd3)

GMU:	124883173(lemd3)

NFU:	107381242(lemd3)

KMR:	108241890(lemd3)

ALIM:

106521829(lemd3)

NWH:	119428415(lemd3)

AOCE:

111579288(lemd3)

EJA:	138202431(lemd3)

BFRE:

138631286(lemd3)

MCEP:

125000263(lemd3)

CSEM:

103383040(lemd3)

POV:	109637525(lemd3)

SSEN:

122766213(lemd3)

SSOE:

131456195(lemd3)

HHIP:

117757579(lemd3)

HSP:	118101527(lemd3)

PPLT:

128428635(lemd3)

SMAU:

118301526(lemd3)

LCF:

108897455

SDU:	111225014(lemd3)

SLAL:

111657552(lemd3)

XGL:	120801356(lemd3)

HCQ:	109513555(lemd3)

SSCV:

125992322(lemd3)

SBIA:

133493719(lemd3)

PEE:	133396935(lemd3)

PTAO:

133471989(lemd3)

BPEC:

110173985(lemd3)

ENY:	140367047(lemd3)

MALB:

109960882(lemd3)

BSPL:

114861980(lemd3)

SJO:	128353211(lemd3)

SSCO:

134004469(lemd3)

TTY:	137176319(lemd3)

GMH:	115541564(lemd3)

SASA:

106609726

STRU:

115182070 115182932

OTW:	121845891(lemd3)

OMY:	110511233 110511321

OGO:

124020272

OKI:	109886739 109886740

OKE:	118378506(lemd3)

OMM:	135516560 135516561

OCLA:

139379614 139392985 139393115

SALP:

112078954

SNH:	120036455 120036474

SFON:

129838869(lemd3)

CCLU:

121555440 123491267

ELS:	105027075(lemd3)

OEP:	134037499(lemd3)

SFM:	108920817 108936619(lemd3)

PKI:	111851560(lemd3)

AANG:

118219004(lemd3) 118231766

AROT:

135245949(lemd3) 135258774

CCOG:

133119075(lemd3) 133135477

LOC:	102690609(lemd3)

PSPA:

121317989 121320094

ARUT:

117419976

PSEX:

120539556(lemd3)

LCM:	102355540(LEMD3)

CMK:	103186106(lemd3)

CPLA:

122559721(lemd3)

CPUN:

140457868(lemd3)

HOC:	132824906(lemd3)

SCAU:

119954711(lemd3)

LERI:

129706466(lemd3)

HAKA:

140734906(lemd3)

PMRN:

116942434(LEMD3)

LRJ:	133349591(LEMD3)

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG3167(MAN1)

DER:

6548400

DSE:

6613001

DSI:	Dsimw501_GD11822(Dsim_GD11822)

DYA:	Dyak_GE14363

DAN:

DSR:

DPO:

DPE:

DMN:	108158746 117190507

DWI:

6640678

DGR:

6560630

DMO:	Dmoj_GI18860

DAZ:

DNV:

DHE:

CCAT:

BOD:	106619383 106624670

BDR:

105224142

AOQ:

129245530

ALUD:

128868925

TDA:	119678106 119681729

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135960385(MAN1)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ013598

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108724263(MAN1)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139109018(Man1)

TLN:	139821202(Man1)

TAME:

143899737(Man1)

HST:

DQU:

CFO:

FEX:

PMEC:

138945267(Man1)

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

CTYP:

141528856(Man1)

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

RFG:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201049

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

API:	100160809 100160851

DNX:	107170833 107171710

AGS:

114127610

RMD:	113547974 113547975

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

LDA:

HVI:

MQU:

PHU:	Phum_PHUM193450

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138707712(MAN1)

BROR:

134534815

IEL:

124167313

HAMR:

139694959(MAN1)

FCD:

110853417

PVM:	113804093 138859710

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123771121(MAN1)

CQD:	128684913(MAN1)

PTRU:

123500267

MNZ:

135218472

MRJ:	136836956(MAN1)

PORN:

139762841(MAN1)

HAZT:

108671176

OOT:	143019986(MAN1)

EAF:

111702447

LSM:	121123947(MAN1)

TCF:

131888072

DSV:

119430954

DALB:

135914230(MAN1)

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

CVS:

ABRU:

UDV:

NAI:	NECAME_04945

BMY:	BM_BM6110(Bma-lem-2)

LOA:	LOAG_06055

TSP:

Tsp_07804

HRO:	HELRODRAFT_114647 HELRODRAFT_124908

LGI:	LOTGIDRAFT_226827

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:	106164027 106164028

SMM:	Smp_211100

SHX:	MS3_00006849(MTRF1L_1)

OVI:	T265_01766

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_25080

AQU:

105313351

» show all

Reference

PMID:15601644

Authors

Lin F, Morrison JM, Wu W, Worman HJ

Title

MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.

Journal

Hum Mol Genet 14:437-45 (2005)
DOI:10.1093/hmg/ddi040

Sequence

[hsa:23592]

LinkDB

DBGET integrated database retrieval system