KEGG   PATHWAY: cvf04382
Entry
cvf04382                    Pathway                                
Name
Cornified envelope formation - Charadrius vociferus (killdeer)
Class
Organismal Systems; Development and regeneration
Pathway map
cvf04382  Cornified envelope formation
cvf04382

Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104281787  DST; dystonin isoform X1 [KO:K10382]
104281846  ITGB4; integrin beta-4 [KO:K06525]
104281972  [KO:K07605]
104281973  [KO:K07605]
104281974  [KO:K07605]
104281975  [KO:K07605]
104281977  [KO:K07605]
104281981  [KO:K07605]
104281982  [KO:K07605]
104281985  [KO:K07605]
104281987  [KO:K07605]
104281988  [KO:K07605]
104281989  [KO:K07605]
104281990  [KO:K07605]
104281991  [KO:K07605]
104281992  KRT80; keratin, type II cytoskeletal 80 [KO:K07605]
104282014  PADI2; protein-arginine deiminase type-2 [KO:K01481] [EC:3.5.3.15]
104282015  PADI1; LOW QUALITY PROTEIN: protein-arginine deiminase type-1 [KO:K01481] [EC:3.5.3.15]
104282019  [KO:K01481] [EC:3.5.3.15]
104282146  BLMH; bleomycin hydrolase [KO:K01372] [EC:3.4.22.40]
104282327  CAPN11; LOW QUALITY PROTEIN: calpain-11 [KO:K01367] [EC:3.4.22.52]
104282677  [KO:K06087]
104282779  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104282934  KAZN; kazrin [KO:K28344]
104283163  PKP1; plakophilin-1 [KO:K10387]
104283381  COL17A1; collagen alpha-1(XVII) chain [KO:K07603]
104283877  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
104284279  HAL; histidine ammonia-lyase [KO:K01745] [EC:4.3.1.3]
104284687  FURIN; furin [KO:K01349] [EC:3.4.21.75]
104284971  CLDN16; claudin-16 [KO:K06087]
104285027  CLDN1; claudin-1 [KO:K06087]
104285658  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
104285922  CLDN11; claudin-11 [KO:K06087]
104286125  ELOVL1; elongation of very long chain fatty acids protein 1 isoform X1 [KO:K10247] [EC:2.3.1.199]
104286661  KDSR; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
104286791  DSP; desmoplakin [KO:K10381]
104286919  [KO:K17731] [EC:1.14.14.177]
104287002  GBA2; LOW QUALITY PROTEIN: non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
104287090  TJP1; tight junction protein ZO-1 [KO:K05701]
104287141  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104287278  [KO:K06087]
104287301  DSG2; LOW QUALITY PROTEIN: desmoglein-2 [KO:K07597]
104287302  [KO:K07599]
104287924  LAMA3; laminin subunit alpha-3 [KO:K06240]
104288059  ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [KO:K13699] [EC:2.3.1.51]
104288183  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
104288220  SPTLC2; LOW QUALITY PROTEIN: serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
104288238  CERS3; ceramide synthase 3 [KO:K24622]
104288289  PKP2; plakophilin-2 [KO:K12642]
104288535  CLDN18; claudin-18 isoform X1 [KO:K06087]
104288543  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
104288669  PCSK6; proprotein convertase subtilisin/kexin type 6 [KO:K08672] [EC:3.4.21.-]
104288676  ELOVL4; elongation of very long chain fatty acids protein 4 [KO:K10249] [EC:2.3.1.199]
104288718  ABCA12; ATP-binding cassette sub-family A member 12 [KO:K05646]
104288754  CLDN20; claudin-20 [KO:K06087]
104289126  SLC27A4; LOW QUALITY PROTEIN: long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
104289501  LAMB3; laminin subunit beta-3 [KO:K06244]
104289600  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
104289841  [KO:K06087]
104289851  CLDN3; claudin-3 [KO:K06087]
104290032  [KO:K05622] [EC:2.3.2.13]
104290057  [KO:K07604]
104290059  KRT20; keratin, type I cytoskeletal 20 [KO:K07604]
104290061  [KO:K07604]
104290062  KRT23; keratin, type I cytoskeletal 23 [KO:K07604]
104290063  [KO:K07604]
104290064  [KO:K07604]
104290065  [KO:K07604]
104290066  [KO:K07604]
104290067  [KO:K07604]
104290068  [KO:K07604]
104290069  [KO:K07604]
104290070  [KO:K07604]
104290074  [KO:K07604]
104290075  [KO:K07604]
104290178  CLDN2; claudin-2 [KO:K06087]
104290215  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
104290273  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
104290396  [KO:K10388]
104290434  S100A11; protein S100-A11 [KO:K23765]
104290435  [KO:K18626]
104290703  [KO:K06087]
104290704  CLDN19; claudin-19 [KO:K06087]
104290836  CAPN1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104290854  UGCG; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
104291067  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104291079  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104291152  CLDN12; claudin-12 [KO:K06087]
104291206  COL7A1; collagen alpha-1(VII) chain [KO:K16628]
104291223  [KO:K23761]
104291224  [KO:K23761]
104291225  S100A16; protein S100-A16 [KO:K23768]
104291246  [KO:K21128]
104291247  S100A7; protein S100-A7 [KO:K21128]
104291248  S100A14; protein S100-A14 [KO:K23767]
104291250  S100A13; protein S100-A13 [KO:K23765]
104291251  S100A1; protein S100-A1 [KO:K23758]
104291316  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
104291549  ST14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
104291621  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104291631  [KO:K10056]
104291764  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
104291780  [KO:K01201] [EC:3.2.1.45]
104291901  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
104292007  CLDN14; claudin-14 [KO:K06087]
104292217  PPL; periplakin [KO:K10386]
104292243  TMEM79; transmembrane protein 79 [KO:K28333]
104292284  CLDN10; claudin-10 [KO:K06087]
104292376  PNPLA1; patatin-like phospholipase domain-containing protein 1 [KO:K16813] [EC:2.3.1.296]
104292401  [KO:K06087]
104292402  [KO:K06087]
104292742  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104292743  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104293252  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
104293365  LAMC2; laminin subunit gamma-2 [KO:K06246]
104293501  [KO:K01201] [EC:3.2.1.45]
104293602  [KO:K01201] [EC:3.2.1.45]
104293841  [KO:K05620] [EC:2.3.2.13]
104294031  LAMA5; laminin subunit alpha-5 [KO:K06240]
104294115  CLDN23; claudin-23 [KO:K06087]
104294602  [KO:K10249] [EC:2.3.1.199]
104294688  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
104294880  ITGA6; integrin alpha-6 [KO:K06485]
104295132  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
104295183  [KO:K06087]
104295209  [KO:K06087]
104295334  SPTLC1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
104295660  SPTLC3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
104295945  EVPL; envoplakin [KO:K10383]
104296011  SLC27A1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
Compound
C00064  L-Glutamine
C00076  Calcium cation
C00135  L-Histidine
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00187  Cholesterol
C00785  Urocanate
C00836  Sphinganine
C01879  5-Oxoproline
C02934  3-Dehydrosphinganine
C22352  Ultra-long-chain fatty acid
C22353  Ultra-long-chain omega-hydroxy fatty acid
C23027  Ultra-long-chain omega-hydroxy fatty acyl-CoA
C23028  Ultra-long-chain omega-hydroxyceramide
C23029  linoleate-esterified acylceramide
C23030  Acylglucosylceramide
Reference
PMID:15803139
  Authors
Candi E, Schmidt R, Melino G
  Title
The cornified envelope: a model of cell death in the skin.
  Journal
Nat Rev Mol Cell Biol 6:328-40 (2005)
DOI:10.1038/nrm1619
Reference
PMID:29153780
  Authors
Egawa G, Kabashima K
  Title
Barrier dysfunction in the skin allergy.
  Journal
Allergol Int 67:3-11 (2018)
DOI:10.1016/j.alit.2017.10.002
Reference
PMID:32218335
  Authors
Ishitsuka Y, Roop DR
  Title
Loricrin: Past, Present, and Future.
  Journal
Int J Mol Sci 21:ijms21072271 (2020)
DOI:10.3390/ijms21072271
Reference
PMID:34639001
  Authors
Gallegos-Alcala P, Jimenez M, Cervantes-Garcia D, Salinas E
  Title
The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.
  Journal
Int J Mol Sci 22:ijms221910661 (2021)
DOI:10.3390/ijms221910661
Reference
PMID:30776025
  Authors
Goleva E, Berdyshev E, Leung DY
  Title
Epithelial barrier repair and prevention of allergy.
  Journal
J Clin Invest 129:1463-1474 (2019)
DOI:10.1172/JCI124608
Reference
PMID:23954553
  Authors
Breiden B, Sandhoff K
  Title
The role of sphingolipid metabolism in cutaneous permeability barrier formation.
  Journal
Biochim Biophys Acta 1841:441-52 (2014)
DOI:10.1016/j.bbalip.2013.08.010
Reference
PMID:31974308
  Authors
Yamamoto H, Hattori M, Chamulitrat W, Ohno Y, Kihara A
  Title
Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid omega-O-acylceramide.
  Journal
Proc Natl Acad Sci U S A 117:2914-2922 (2020)
DOI:10.1073/pnas.1917525117
Reference
PMID:36902463
  Authors
Ge F, Sun K, Hu Z, Dong X
  Title
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method.
  Journal
Int J Mol Sci 24:ijms24055035 (2023)
DOI:10.3390/ijms24055035
Related
pathway
cvf00600  Sphingolipid metabolism
KO pathway
ko04382   

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