KEGG   DISEASE: マラリア
エントリ  
H00361                                                             
名称    
マラリア
概要    
Malaria, the most common parasitic disease in the world, is caused by Plasmodium parasites that are transmitted by female Anopheline mosquitoes. Plasmodium infections result in a spectrum of clinical effects, including asymptomatic parasitemia, severe malaria, and death. Most severe cases occur in sub-Saharan Africa. In severe malaria, complications such as anemia, respiratory distress, renal failure, and cerebral malaria are observed in addition to cyclical fevers.
カテゴリ  
寄生虫感染症
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 01 感染症・寄生虫症
  寄生虫症
   マラリア
    1F40  熱帯熱マラリア原虫によるマラリア
     H00361  マラリア
    1F41  三日熱マラリア原虫によるマラリア
     H00361  マラリア
    1F42  四日熱マラリア原虫によるマラリア
     H00361  マラリア
    1F43  卵形マラリア原虫によるマラリア
     H00361  マラリア
ゲノムに基づく感染症分類 [BR:jp08401]
 寄生虫感染症(原生生物)
  アルベオラータによる感染症
   H00361  マラリア
感染症法による感染症分類 [jp08406.html]
 H00361
疾患パスウェイ
hsa05144  マラリア
病因遺伝子 
ACKR1 (protection) [HSA:2532] [KO:K06574]
CD36 (susceptibility/reduced risk) [HSA:948] [KO:K06259]
CISH (susceptibility) [HSA:1154] [KO:K04701]
CR1 (resistance) [HSA:1378] [KO:K04011]
FCGR2A (susceptibility) [HSA:2212] [KO:K06472]
FCGR2B (resistance) [HSA:2213] [KO:K12560]
G6PD (resistance) [HSA:2539] [KO:K00036]
GYPA (resistance) [HSA:2993] [KO:K06575]
GYPB (resistance) [HSA:2994] [KO:K20925]
GYPC (resistance) [HSA:2995] [KO:K06576]
HBB (resistance) [HSA:3043] [KO:K13823]
ICAM1 (susceptibility) [HSA:3383] [KO:K06490]
NOS2 (resistance) [HSA:4843] [KO:K13241]
SLC4A1 (resistance) [HSA:6521] [KO:K06573]
TIRAP (protection) [HSA:114609] [KO:K05403]
TNF (susceptibility) [HSA:7124] [KO:K03156]
病原体   
Plasmodium falciparum [GN:pfa pfd pfh] (Falciparum malaria)
Plasmodium vivax [GN:pvx] (Vivax malaria)
Plasmodium knowlesi H [GN:pkn]
Plasmodium malariae [GN:pmal]
Plasmodium brasilianum [GN:pbrs]
Plasmodium ovale
治療薬   
プリマキンリン酸塩 [DR:D02126]
アトバコン・プログアニル塩酸塩 [DR:D02472]
メフロキン塩酸塩 [DR:D00831]
アルテメテル・ルメファントリン [DR:D02484]
コメント  
Vector: Anopheles gambiae (African malaria mosquito) [GN:aga]
リンク   
ICD-11: 1F40 1F41 1F42 1F43
MeSH: D008288
MedlinePlus: 000621
OMIM: 611162
文献    
  著者
Antinori S, Galimberti L, Milazzo L, Corbellino M
  タイトル
Plasmodium knowlesi: the emerging zoonotic malaria parasite.
  雑誌
Acta Trop 125:191-201 (2013)
DOI:10.1016/j.actatropica.2012.10.008
文献    
  著者
Plewes K, Leopold SJ, Kingston HWF, Dondorp AM
  タイトル
Malaria: What's New in the Management of Malaria?
  雑誌
Infect Dis Clin North Am 33:39-60 (2019)
DOI:10.1016/j.idc.2018.10.002
文献    
PMID:10570183 (ACKR1)
  著者
Zimmerman PA, Woolley I, Masinde GL, Miller SM, McNamara DT, Hazlett F, Mgone CS, Alpers MP, Genton B, Boatin BA, Kazura JW
  タイトル
Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.
  雑誌
Proc Natl Acad Sci U S A 96:13973-7 (1999)
DOI:10.1073/pnas.96.24.13973
文献    
PMID:10890433 (CD36)
  著者
Aitman TJ, Cooper LD, Norsworthy PJ, Wahid FN, Gray JK, Curtis BR, McKeigue PM, Kwiatkowski D, Greenwood BM, Snow RW, Hill AV, Scott J
  タイトル
Malaria susceptibility and CD36 mutation.
  雑誌
Nature 405:1015-6 (2000)
DOI:10.1038/35016636
文献    
PMID:20484391 (CISH)
  著者
Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC, Kam KM, Crampin AC, Ngwira B, Leung CC, Tam CM, Chan CY, Sung JJ, Yew WW, Toh KY, Tay SK, Kwiatkowski D, Lienhardt C, Hien TT, Day NP, Peshu N, Marsh K, Maitland K, Scott JA, Williams TN, Berkley JA, Floyd S, Tang NL, Fine PE, Goh DL, Hill AV
  タイトル
CISH and susceptibility to infectious diseases.
  雑誌
N Engl J Med 362:2092-101 (2010)
DOI:10.1056/NEJMoa0905606
文献    
PMID:18954261 (CR1)
  著者
Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai H, Naka I, Putaporntip C, Jongwutiwes S, Tokunaga K
  タイトル
A functional single-nucleotide polymorphism in the CR1 promoter region contributes to protection against cerebral malaria.
  雑誌
J Infect Dis 198:1880-91 (2008)
DOI:10.1086/593338
文献    
PMID:12421634 (FCGR2A)
  著者
Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K
  タイトル
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria.
  雑誌
Parasitol Int 51:361-6 (2002)
DOI:10.1016/s1383-5769(02)00040-5
文献    
PMID:17435165 (FCGR2B)
  著者
Clatworthy MR, Willcocks L, Urban B, Langhorne J, Williams TN, Peshu N, Watkins NA, Floto RA, Smith KG
  タイトル
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.
  雑誌
Proc Natl Acad Sci U S A 104:7169-74 (2007)
DOI:10.1073/pnas.0608889104
文献    
PMID:13682585 (G6PD)
  著者
ALLISON AC, CLYDE DF
  タイトル
Malaria in African children with deficient erythrocyte glucose-6-phosphate dehydrogenase.
  雑誌
Br Med J 1:1346-9 (1961)
DOI:10.1136/bmj.1.5236.1346
文献    
PMID:26416757 (GYPA GYPB GYPC)
  著者
Band G, Rockett KA, Spencer CC, Kwiatkowski DP
  タイトル
A novel locus of resistance to severe malaria in a region of ancient balancing selection.
  雑誌
Nature 526:253-7 (2015)
DOI:10.1038/nature15390
文献    
PMID:11713529 (HBB)
  著者
Modiano D, Luoni G, Sirima BS, Simpore J, Verra F, Konate A, Rastrelli E, Olivieri A, Calissano C, Paganotti GM, D'Urbano L, Sanou I, Sawadogo A, Modiano G, Coluzzi M
  タイトル
Haemoglobin C protects against clinical Plasmodium falciparum malaria.
  雑誌
Nature 414:305-8 (2001)
DOI:10.1038/35104556
文献    
PMID:9259284 (ICAM1)
  著者
Fernandez-Reyes D, Craig AG, Kyes SA, Peshu N, Snow RW, Berendt AR, Marsh K, Newbold CI
  タイトル
A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya.
  雑誌
Hum Mol Genet 6:1357-60 (1997)
DOI:10.1093/hmg/6.8.1357
文献    
PMID:9457101 (NOS2)
  著者
Kun JF, Mordmuller B, Lell B, Lehman LG, Luckner D, Kremsner PG
  タイトル
Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria.
  雑誌
Lancet 351:265-6 (1998)
DOI:10.1016/S0140-6736(05)78273-8
文献    
PMID:10403343 (SLC4A1)
  著者
Allen SJ, O'Donnell A, Alexander ND, Mgone CS, Peto TE, Clegg JB, Alpers MP, Weatherall DJ
  タイトル
Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3.
  雑誌
Am J Trop Med Hyg 60:1056-60 (1999)
DOI:10.4269/ajtmh.1999.60.1056
文献    
PMID:17322885 (TIRAP)
  著者
Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'Neill LA, Hill AV
  タイトル
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
  雑誌
Nat Genet 39:523-8 (2007)
DOI:10.1038/ng1976
文献    
PMID:7935762 (TNF)
  著者
McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D
  タイトル
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.
  雑誌
Nature 371:508-10 (1994)
DOI:10.1038/371508a0
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