KEGG   PATHWAY: dsi00260
Entry
dsi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Drosophila simulans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
dsi00260  Glycine, serine and threonine metabolism
dsi00260

Module
dsi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:dsi00260]
dsi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:dsi00260]
dsi_M00621  Glycine cleavage system [PATH:dsi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD18368  Dsim_GD18368; uncharacterized protein, isoform A [KO:K01620] [EC:4.1.2.48]
Dsimw501_GD16224  Dsim_GD16224; uncharacterized protein [KO:K00600] [EC:2.1.2.1]
Dsimw501_GD16801  Dsim_GD16801; uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Dsimw501_GD24284  Dsim_GD24284; uncharacterized protein [KO:K00049] [EC:1.1.1.79 1.1.1.81]
Dsimw501_GD24286  Dsim_GD24286; uncharacterized protein, isoform A [KO:K00049] [EC:1.1.1.79 1.1.1.81]
Dsimw501_GD19816  Dsim_GD19816; uncharacterized protein [KO:K00049] [EC:1.1.1.79 1.1.1.81]
Dsimw501_GD24283  Dsim_GD24283; uncharacterized protein, isoform F [KO:K00049] [EC:1.1.1.79 1.1.1.81]
Dsimw501_GD23155  Dsim_GD23155; uncharacterized protein [KO:K11529] [EC:2.7.1.165]
Dsimw501_GD20588  Dsim_GD20588; uncharacterized protein [KO:K01834] [EC:5.4.2.11]
Dsimw501_GD29597  Dsim_GD29597; uncharacterized protein [KO:K01834] [EC:5.4.2.11]
Dsimw501_GD20944  Dsim_GD20944; uncharacterized protein, isoform A [KO:K01834] [EC:5.4.2.11]
Dsimw501_GD22186  Dsim_GD22186; uncharacterized protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Dsimw501_GD21426  Dsim_GD21426; uncharacterized protein [KO:K00831] [EC:2.6.1.52]
Dsimw501_GD10671  Dsim_GD10671; uncharacterized protein [KO:K01079] [EC:3.1.3.3]
Dsimw501_GD29449  Dsim_GD29449; uncharacterized protein [KO:K00639] [EC:2.3.1.29]
Dsimw501_GD14889  Dsim_GD14889; uncharacterized protein [KO:K15789] [EC:1.1.1.103]
Dsimw501_GD11815  Dsim_GD11815; uncharacterized protein [KO:K00643] [EC:2.3.1.37]
Dsimw501_GD18680  Dsim_GD18680; uncharacterized protein [KO:K00281] [EC:1.4.4.2]
Dsimw501_GD23726  Dsim_GD23726; uncharacterized protein [KO:K00605] [EC:2.1.2.10]
Dsimw501_GD14729  Dsim_GD14729; uncharacterized protein [KO:K00382] [EC:1.8.1.4]
Dsimw501_GD12129  Dsim_GD12129; uncharacterized protein [KO:K02437]
Dsimw501_GD23432  Dsim_GD23432; uncharacterized protein [KO:K00273] [EC:1.4.3.3]
Dsimw501_GD12056  Dsim_GD12056; uncharacterized protein, isoform B [KO:K00827] [EC:2.6.1.44 2.6.1.40]
Dsimw501_GD12292  Dsim_GD12292; uncharacterized protein [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Dsimw501_GD25443  Dsim_GD25443; uncharacterized protein [KO:K00314] [EC:1.5.8.3]
Dsimw501_GD18854  Dsim_GD18854; uncharacterized protein [KO:K00552] [EC:2.1.1.20]
Dsimw501_GD17507  Dsim_GD17507; uncharacterized protein [KO:K01697] [EC:4.2.1.22]
Dsimw501_GD11400  Dsim_GD11400; uncharacterized protein [KO:K01758] [EC:4.4.1.1]
Dsimw501_GD18609  Dsim_GD18609; uncharacterized protein [KO:K01754] [EC:4.3.1.19]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
dsi00010  Glycolysis / Gluconeogenesis
dsi00020  Citrate cycle (TCA cycle)
dsi00230  Purine metabolism
dsi00250  Alanine, aspartate and glutamate metabolism
dsi00270  Cysteine and methionine metabolism
dsi00290  Valine, leucine and isoleucine biosynthesis
dsi00330  Arginine and proline metabolism
dsi00470  D-Amino acid metabolism
dsi00564  Glycerophospholipid metabolism
dsi00600  Sphingolipid metabolism
dsi00620  Pyruvate metabolism
dsi00630  Glyoxylate and dicarboxylate metabolism
dsi00640  Propanoate metabolism
dsi00860  Porphyrin metabolism
dsi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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