KEGG   PATHWAY: dsi00600
Entry
dsi00600                    Pathway                                
Name
Sphingolipid metabolism - Drosophila simulans
Class
Metabolism; Lipid metabolism
Pathway map
dsi00600  Sphingolipid metabolism
dsi00600

Module
dsi_M00094  Ceramide biosynthesis [PATH:dsi00600]
dsi_M00099  Sphingosine biosynthesis [PATH:dsi00600]
dsi_M00100  Sphingosine degradation [PATH:dsi00600]
Other DBs
GO: 0006665
Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD10076  Dsim_GD10076; uncharacterized protein, isoform A [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD10375  Dsim_GD10375; uncharacterized protein [KO:K04628] [EC:2.4.1.47]
Dsimw501_GD10653  Dsim_GD10653; uncharacterized protein, isoform A [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD10944  Dsim_GD10944; uncharacterized protein [KO:K00654] [EC:2.3.1.50]
Dsimw501_GD11642  Dsim_GD11642; uncharacterized protein [KO:K00720] [EC:2.4.1.80]
Dsimw501_GD11848  Dsim_GD11848; uncharacterized protein, isoform E [KO:K12350] [EC:3.1.4.12]
Dsimw501_GD12067  Dsim_GD12067; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD13722  Dsim_GD13722; uncharacterized protein [KO:K04718] [EC:2.7.1.91]
Dsimw501_GD13741  Dsim_GD13741; uncharacterized protein [KO:K12351] [EC:3.1.4.12]
Dsimw501_GD13835  Dsim_GD13835; uncharacterized protein, isoform A [KO:K12373] [EC:3.2.1.52]
Dsimw501_GD15029  Dsim_GD15029; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD15030  Dsim_GD15030; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD15031  Dsim_GD15031; uncharacterized protein, isoform A [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD15032  Dsim_GD15032; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dsimw501_GD16774  Dsim_Sap-r; Saposin-related [KO:K12382]
Dsimw501_GD16914  Dsim_GD16914; uncharacterized protein [KO:K12373] [EC:3.2.1.52]
Dsimw501_GD17022  Dsim_GD17022; uncharacterized protein [KO:K04718] [EC:2.7.1.91]
Dsimw501_GD18220  Dsim_GD18220; uncharacterized protein [KO:K04708] [EC:1.1.1.102]
Dsimw501_GD18795  Dsim_GD18795; uncharacterized protein [KO:K12309] [EC:3.2.1.23]
Dsimw501_GD19624  Dsim_GD19624; uncharacterized protein [KO:K04715] [EC:2.7.1.138]
Dsimw501_GD20627  Dsim_GD20627; uncharacterized protein [KO:K12353] [EC:3.1.4.12]
Dsimw501_GD21027  Dsim_GD21027; uncharacterized protein [KO:K01201] [EC:3.2.1.45]
Dsimw501_GD21030  Dsim_GD21030; uncharacterized protein [KO:K01201] [EC:3.2.1.45]
Dsimw501_GD21520  Dsim_GD21520; uncharacterized protein, isoform A [KO:K12349] [EC:3.5.1.23]
Dsimw501_GD22613  Dsim_GD22613; uncharacterized protein, isoform C [KO:K12309] [EC:3.2.1.23]
Dsimw501_GD23376  Dsim_GD23376; uncharacterized protein, isoform A [KO:K04712] [EC:1.14.19.17 1.14.18.5]
Dsimw501_GD23959  Dsim_GD23959; uncharacterized protein, isoform A [KO:K17108] [EC:3.2.1.45]
Dsimw501_GD24010  Dsim_GD24010; uncharacterized protein [KO:K00654] [EC:2.3.1.50]
Dsimw501_GD24242  Dsim_GD24242; uncharacterized protein, isoform C [KO:K01441] [EC:3.5.1.23]
Dsimw501_GD25004  Dsim_GD25004; uncharacterized protein, isoform A [KO:K26283]
Dsimw501_GD25496  Dsim_GD25496; uncharacterized protein [KO:K01634] [EC:4.1.2.27]
Dsimw501_GD28007  Dsim_GD28007; uncharacterized protein, isoform A [KO:K23727]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
dsi00260  Glycine, serine and threonine metabolism
dsi00601  Glycosphingolipid biosynthesis - lacto and neolacto series
dsi00603  Glycosphingolipid biosynthesis - globo and isoglobo series
dsi00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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