KEGG   PATHWAY: eai00330
Entry
eai00330                    Pathway                                
Name
Arginine and proline metabolism - Equus asinus (ass)
Class
Metabolism; Amino acid metabolism
Pathway map
eai00330  Arginine and proline metabolism
eai00330

Module
eai_M00015  Proline biosynthesis, glutamate => proline [PATH:eai00330]
eai_M00047  Creatine pathway [PATH:eai00330]
eai_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:eai00330]
eai_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:eai00330]
eai_M00970  Proline degradation, proline => glutamate [PATH:eai00330]
eai_M00972  Proline metabolism [PATH:eai00330]
Other DBs
GO: 0006525 0006560
Organism
Equus asinus (ass) [GN:eai]
Gene
106822221  GOT2; LOW QUALITY PROTEIN: aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
106822691  [KO:K01581] [EC:4.1.1.17]
106823361  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
106823380  AOC1; amiloride-sensitive amine oxidase [copper-containing] isoform X1 [KO:K11182] [EC:1.4.3.22]
106827532  [KO:K00318] [EC:1.5.5.2]
106827971  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform X1 [KO:K00294] [EC:1.2.1.88]
106828006  AGMAT; agmatinase, mitochondrial [KO:K27001]
106829030  AZIN2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
106829258  PRODH2; hydroxyproline dehydrogenase isoform X1 [KO:K11394] [EC:1.5.5.3]
106829598  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
106831128  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
106831684  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X1 [KO:K00472] [EC:1.14.11.2]
106832226  [KO:K01611] [EC:4.1.1.50]
106832860  CNDP1; beta-Ala-His dipeptidase isoform X1 [KO:K05604] [EC:3.4.13.20]
106832864  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
106833657  CARNS1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
106834186  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
106834989  GATM; LOW QUALITY PROTEIN: glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
106835019  [KO:K00933] [EC:2.7.3.2]
106835383  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
106835473  [KO:K01611] [EC:4.1.1.50]
106835513  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
106836679  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
106837693  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
106838292  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
106838325  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
106838326  [KO:K00274] [EC:1.4.3.4]
106838849  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
106839619  CKB; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
106839766  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
106841024  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
106841190  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
106841607  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
106841916  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
106842110  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
106842261  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
106842394  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
106842819  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
106843896  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
106844215  SAT2; thialysine N-epsilon-acetyltransferase [KO:K00657] [EC:2.3.1.57]
106844596  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
106844731  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
106844773  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
106844960  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 [KO:K18123] [EC:4.1.3.16]
106845990  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1 [KO:K00286] [EC:1.5.1.2]
106846048  ODC1; ornithine decarboxylase isoform X1 [KO:K01581] [EC:4.1.1.17]
106846079  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
106846693  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
106847060  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
106847685  SMOX; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
106848086  DAO; D-amino-acid oxidase isoform X3 [KO:K00273] [EC:1.4.3.3]
106848136  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
106848423  CKM; creatine kinase M-type [KO:K27382]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
eai00020  Citrate cycle (TCA cycle)
eai00220  Arginine biosynthesis
eai00250  Alanine, aspartate and glutamate metabolism
eai00260  Glycine, serine and threonine metabolism
eai00270  Cysteine and methionine metabolism
eai00310  Lysine degradation
eai00410  beta-Alanine metabolism
eai00470  D-Amino acid metabolism
eai00480  Glutathione metabolism
eai00630  Glyoxylate and dicarboxylate metabolism
eai00650  Butanoate metabolism
eai00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

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