KEGG   PATHWAY: eay00260
Entry
eay00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Erwinia amylovora ATCC 49946
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eay00260  Glycine, serine and threonine metabolism
eay00260

Module
eay_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eay00260]
eay_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eay00260]
eay_M00555  Betaine biosynthesis, choline => betaine [PATH:eay00260]
eay_M00621  Glycine cleavage system [PATH:eay00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Erwinia amylovora ATCC 49946 [GN:eay]
Gene
EAM_0253  lysC; lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
EAM_0642  thrA; bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EAM_0134  metL; bifunctional aspartokinase/homoserine dehydrogenase II [includes: aspartokinase II; homoserine dehydrogenase I] [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EAM_3273  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EAM_0643  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
EAM_0644  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
EAM_1315  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EAM_2497  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EAM_3441  tkrA; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EAM_2709  garK; glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
EAM_1194  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (phosphoglyceromutase) [KO:K01834] [EC:5.4.2.11]
EAM_0636  gpmB; probable phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
EAM_2798  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EAM_1337  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
EAM_0621  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EAM_1715  ydfG; NADP-dependent L-serine/L-allo-threonine dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EAM_2789  gcvP; glycine dehydrogenase [decarboxylating] (glycine cleavage system P-protein) [KO:K00281] [EC:1.4.4.2]
EAM_2791  gcvT; aminomethyltransferase (glycine cleavage system protein) [KO:K00605] [EC:2.1.2.10]
EAM_0749  lpdA; dihydrolipoyl dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) [KO:K00382] [EC:1.8.1.4]
EAM_2790  gcvH; glycine cleavage system H protein [KO:K02437]
EAM_2910  hsvA; putative amidinotransferase [KO:K00613] [EC:2.1.4.1]
EAM_2610  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
EAM_1687  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EAM_1686  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EAM_1964  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
EAM_0155  ilvA; threonine dehydratase biosynthetic (threonin deaminase) [KO:K01754] [EC:4.3.1.19]
EAM_1882  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
EAM_1881  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
EAM_2960  dat; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
EAM_0361  putative decarboxylase [KO:K13745] [EC:4.1.1.86]
EAM_2959  ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eay00010  Glycolysis / Gluconeogenesis
eay00020  Citrate cycle (TCA cycle)
eay00230  Purine metabolism
eay00250  Alanine, aspartate and glutamate metabolism
eay00270  Cysteine and methionine metabolism
eay00290  Valine, leucine and isoleucine biosynthesis
eay00300  Lysine biosynthesis
eay00330  Arginine and proline metabolism
eay00460  Cyanoamino acid metabolism
eay00470  D-Amino acid metabolism
eay00564  Glycerophospholipid metabolism
eay00600  Sphingolipid metabolism
eay00620  Pyruvate metabolism
eay00630  Glyoxylate and dicarboxylate metabolism
eay00640  Propanoate metabolism
eay00680  Methane metabolism
eay00860  Porphyrin metabolism
eay00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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