KEGG   PATHWAY: ecf00230
Entry
ecf00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O157:H7 EC4115 (EHEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ecf00230  Purine metabolism
ecf00230

Module
ecf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecf00230]
ecf_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecf00230]
ecf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecf00230]
ecf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecf00230]
ecf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecf00230]
ecf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecf00230]
ecf_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecf00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O157:H7 EC4115 (EHEC) [GN:ecf]
Gene
ECH74115_4348  hydrolase, NUDIX family [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ECH74115_4702  nudE; ADP compounds hydrolase NudE [KO:K08312] [EC:3.6.1.-]
ECH74115_5898  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ECH74115_0783  pgm; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
ECH74115_1688  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
ECH74115_3452  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ECH74115_5474  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
ECH74115_3723  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
ECH74115_2584  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ECH74115_3792  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
ECH74115_3722  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
ECH74115_0623  purK; phosphoribosylaminoimidazole carboxylase, ATPase subunit [KO:K01589] [EC:6.3.4.18]
ECH74115_0624  purE; phosphoribosylaminoimidazole carboxylase, catalytic subunit [KO:K01588] [EC:5.4.99.18]
ECH74115_3698  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
ECH74115_1592  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ECH74115_5476  purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ECH74115_0559  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ECH74115_0572  ushA; UDP-sugar hydrolase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ECH74115_3995  surE; multifunctional protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ECH74115_0766  nagD; nagD protein [KO:K02566] [EC:3.1.3.5]
ECH74115_4704  HAD hydrolase, IA family [KO:K20881] [EC:3.1.3.-]
ECH74115_0569  gsk; inosine kinase [KO:K00892] [EC:2.7.1.73]
ECH74115_5899  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ECH74115_0465  conserved hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ECH74115_3834  conserved hypothetical protein TIGR00726 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ECH74115_0133  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ECH74115_3732  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
ECH74115_3743  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
ECH74115_5909  conserved hypothetical protein [KO:K01529] [EC:3.6.1.73]
ECH74115_4257  rdgB; non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
ECH74115_0283  gpt; xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ECH74115_4156  xdhA; xanthine dehydrogenase [KO:K00087] [EC:1.17.1.4]
ECH74115_4157  xdhB; xanthine dehydrogenase, FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
ECH74115_4158  xdhC; xanthine dehydrogenase, iron-sulfur binding subunit [KO:K13480]
ECH74115_0330  xanthine dehydrogenase family protein, molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
ECH74115_0331  FAD binding domain in molybdopterin dehydrogenase [KO:K11178] [EC:1.17.1.4]
ECH74115_0332  iron-sulfur cluster binding protein [KO:K13483]
ECH74115_3731  guaA; GMP synthetase [KO:K01951] [EC:6.3.5.2]
ECH74115_0111  guaC; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
ECH74115_4173  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
ECH74115_5020  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
ECH74115_3368  nrdA; ribonucleoside-diphosphate reductase, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECH74115_3919  nrdE; ribonucleoside-diphosphate reductase, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECH74115_3369  nrdB; ribonucleoside-diphosphate reductase, beta subunit [KO:K00526] [EC:1.17.4.1]
ECH74115_3920  nrdF; ribonucleoside-diphosphate reductase, beta subunit [KO:K00526] [EC:1.17.4.1]
ECH74115_5758  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
ECH74115_0170  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
ECH74115_3430  yfbR; 5'-nucleotidase [KO:K08722] [EC:3.1.3.89]
ECH74115_5538  conserved hypothetical protein [KO:K06952] [EC:3.1.3.89]
ECH74115_5022  spoT; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ECH74115_3725  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECH74115_5212  gppA; guanosine-5'-triphosphate,3'-diphosphate diphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECH74115_4044  relA; GTP diphosphokinase [KO:K00951] [EC:2.7.6.5]
ECH74115_5244  cyaA; adenylate cyclase, class I [KO:K05851] [EC:4.6.1.1]
ECH74115_5693  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ECH74115_2335  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ECH74115_2824  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ECH74115_4059  conserved hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ECH74115_5095  ade; adenine deaminase [KO:K01486] [EC:3.5.4.2]
ECH74115_5730  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ECH74115_0566  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
ECH74115_4041  MazG family protein [KO:K04765] [EC:3.6.1.9]
ECH74115_4346  icc; protein icc [KO:K03651] [EC:3.1.4.53]
ECH74115_0054  bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [KO:K01525] [EC:3.6.1.41]
ECH74115_4002  cysC; adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
ECH74115_4003  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
ECH74115_4004  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
ECH74115_2749  transthyretin family protein [KO:K07127] [EC:3.5.2.17]
ECH74115_0617  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ECH74115_0616  conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
ECH74115_0606  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ECH74115_1323  ureC; urease, alpha subunit [KO:K01428] [EC:3.5.1.5]
ECH74115_1322  ureB; urease, beta subunit [KO:K01429] [EC:3.5.1.5]
ECH74115_1321  ureA; urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
ECH74115_0618  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ECH74115_0388  carbamate kinase family protein [KO:K00926] [EC:2.7.2.2]
ECH74115_4164  carbamate kinase arcC homolog [KO:K00926] [EC:2.7.2.2]
ECH74115_0622  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecf00030  Pentose phosphate pathway
ecf00220  Arginine biosynthesis
ecf00250  Alanine, aspartate and glutamate metabolism
ecf00260  Glycine, serine and threonine metabolism
ecf00340  Histidine metabolism
ecf00630  Glyoxylate and dicarboxylate metabolism
ecf00730  Thiamine metabolism
ecf00740  Riboflavin metabolism
ecf00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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