KEGG   PATHWAY: eco00230
Entry
eco00230                    Pathway                                
Name
Purine metabolism - Escherichia coli K-12 MG1655
Class
Metabolism; Nucleotide metabolism
Pathway map
eco00230  Purine metabolism
eco00230

Module
eco_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:eco00230]
eco_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:eco00230]
eco_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:eco00230]
eco_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:eco00230]
eco_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eco00230]
eco_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:eco00230]
eco_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:eco00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b0049  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
b0104  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
b0125  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
b0160  dgt; dGTP triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
b0238  gpt; xanthine-guanine phsophoribosyltransferase [KO:K00769] [EC:2.4.2.22]
b0284  paoC; aldehyde dehydrogenase: molybdenum cofactor-binding subunit [KO:K11177] [EC:1.17.1.4]
b0285  paoB; aldehyde dehydrogenase, FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
b0286  paoA; aldehyde dehydrogenase, Fe-S subunit [KO:K13483]
b0323  yahI; carbamate kinase-like protein YahI [KO:K00926] [EC:2.7.2.2]
b0391  ppnP; nucleoside phosphorylase PpnP [KO:K09913] [EC:2.4.2.1 2.4.2.2]
b0469  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
b0474  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
b0477  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
b0480  ushA; 5'-nucleotidase/UDP-sugar hydrolase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
b0505  allA; ureidoglycolate lyase [KO:K01483] [EC:4.3.2.3]
b0512  allB; allantoinase [KO:K01466] [EC:3.5.2.5]
b0515  allE; (S)-ureidoglycine aminohydrolase [KO:K14977] [EC:3.5.3.26]
b0516  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
b0517  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
b0518  fdrA; putative oxamate carbamoyltransferase FdrA [KO:K02381] [EC:2.1.3.5]
b0520  ylbF; DUF2877 domain-containing protein YlbF [KO:K28795]
b0521  ybcF; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
b0522  purK; 5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
b0523  purE; N(5)-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
b0675  umpH; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
b0688  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
b1131  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
b1207  prs; ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
b1623  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
b1849  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
b1970  hiuH; hydroxyisourate hydrolase/transthyretin-related protein [KO:K07127] [EC:3.5.2.17]
b1982  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
b2234  nrdA; ribonucleoside-diphosphate reductase 1 subunit alpha [KO:K00525] [EC:1.17.4.1]
b2235  nrdB; ribonucleoside-diphosphate reductase 1 subunit beta [KO:K00526] [EC:1.17.4.1]
b2291  yfbR; dCMP phosphohydrolase [KO:K08722] [EC:3.1.3.89]
b2312  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
b2361  yfdR; 5'-deoxynucleotidase [KO:K06952] [EC:3.1.3.89]
b2407  xapA; xanthosine phosphorylase [KO:K03783] [EC:2.4.2.1]
b2476  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
b2499  purM; phosphoribosylformylglycinamide cyclo-ligase [KO:K01933] [EC:6.3.3.1]
b2500  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
b2502  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
b2507  guaA; GMP synthetase [KO:K01951] [EC:6.3.5.2]
b2508  guaB; inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
b2518  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
b2557  purL; phosphoribosylformylglycinamide synthetase [KO:K01952] [EC:6.3.5.3]
b2593  yfiH; purine nucleoside phosphorylase YfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
b2675  nrdE; ribonucleoside-diphosphate reductase 2 subunit alpha [KO:K00525] [EC:1.17.4.1]
b2676  nrdF; ribonucleoside-diphosphate reductase 2 subunit beta [KO:K00526] [EC:1.17.4.1]
b2744  umpG; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
b2750  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
b2751  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
b2752  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
b2781  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
b2784  relA; GDP/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
b2795  ppnN; nucleotide 5'-monophosphate nucleosidase [KO:K06966] [EC:3.2.2.10 3.2.2.-]
b2866  xdhA; putative xanthine dehydrogenase molybdenum-binding subunit XdhA [KO:K00087] [EC:1.17.1.4]
b2867  xdhB; putative xanthine dehydrogenase FAD-binding subunit XdhB [KO:K13479] [EC:1.17.1.4]
b2868  xdhC; putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC [KO:K13480]
b2874  yqeA; putative amino acid kinase YqeA [KO:K00926] [EC:2.7.2.2]
b2883  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
b2954  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
b3032  cpdA; cAMP phosphodiesterase [KO:K03651] [EC:3.1.4.53]
b3034  nudF; ADP-sugar pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
b3380  yhfW; putative mutase YhfW [KO:K01839] [EC:5.4.2.7]
b3397  nudE; ADP-sugar diphosphatase NudE [KO:K08312] [EC:3.6.1.-]
b3399  yrfG; purine nucleotidase [KO:K20881] [EC:3.1.3.-]
b3648  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
b3650  spoT; bifunctional (p)ppGpp synthase/hydrolase SpoT [KO:K01139] [EC:2.7.6.5 3.1.7.2]
b3665  adeD; adenine deaminase [KO:K01486] [EC:3.5.4.2]
b3779  gpp; guanosine-5'-triphosphate,3'-diphosphate phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
b3806  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
b4005  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
b4006  purH; bifunctional AICAR transformylase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
b4177  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
b4213  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
b4238  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
b4383  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
b4384  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
b4394  yjjX; inosine/xanthosine triphosphatase [KO:K01529]
b4572  ylbE; DUF1116 domain-containing protein YlbE [KO:K28794]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
eco00030  Pentose phosphate pathway
eco00220  Arginine biosynthesis
eco00250  Alanine, aspartate and glutamate metabolism
eco00260  Glycine, serine and threonine metabolism
eco00340  Histidine metabolism
eco00630  Glyoxylate and dicarboxylate metabolism
eco00730  Thiamine metabolism
eco00740  Riboflavin metabolism
eco00790  Folate biosynthesis
KO pathway
ko00230   

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