KEGG   PATHWAY: eco00630
Entry
eco00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli K-12 MG1655
Class
Metabolism; Carbohydrate metabolism
Pathway map
eco00630  Glyoxylate and dicarboxylate metabolism
eco00630

Module
eco_M00012  Glyoxylate cycle [PATH:eco00630]
eco_M00621  Glycine cleavage system [PATH:eco00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b0116  lpd; lipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
b0118  acnB; AcnB [KO:K01682] [EC:4.2.1.3 4.2.1.99]
b0333  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
b0507  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
b0508  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
b0509  glxR; tartronate semialdehyde reductase 2 [KO:K00042] [EC:1.1.1.60]
b0514  glxK; glycerate 2-kinase 2 [KO:K00865] [EC:2.7.1.165]
b0720  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
b1033  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
b1232  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
b1276  acnA; aconitate hydratase 1 [KO:K27802]
b1415  aldA; aldehyde dehydrogenase A [KO:K07248] [EC:1.2.1.22 1.2.1.21]
b1732  katE; catalase HPII [KO:K03781] [EC:1.11.1.6]
b1800  dmlA; D-malate/3-isopropylmalate dehydrogenase (decarboxylating) [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
b1850  eda; KHG/KDPG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
b2224  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
b2373  oxc; oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
b2374  frc; formyl-CoA transferase [KO:K07749] [EC:2.8.3.16]
b2551  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
b2799  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
b2844  yqeF; putative acyltransferase [KO:K00626] [EC:2.3.1.9]
b2903  gcvP; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
b2904  gcvH; glycine cleavage system H protein [KO:K02437]
b2905  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
b2917  scpA; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
b2976  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
b2979  glcD; glycolate dehydrogenase, putative FAD-linked subunit [KO:K00104] [EC:1.1.99.14]
b3061  ttdA; L(+)-tartrate dehydratase subunit alpha [KO:K03779] [EC:4.2.1.32]
b3062  ttdB; L(+)-tartrate dehydratase subunit beta [KO:K03780] [EC:4.2.1.32]
b3124  garK; glycerate 2-kinase 1 [KO:K00865] [EC:2.7.1.165]
b3125  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
b3236  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
b3385  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
b3553  ghrB; glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
b3870  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
b3892  fdoI; formate dehydrogenase O subunit gamma [KO:K00127]
b3893  fdoH; formate dehydrogenase O subunit beta [KO:K00124]
b3894  fdoG; formate dehydrogenase O subunit alpha [KO:K00123] [EC:1.17.1.9]
b4014  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
b4015  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
b4069  acs; acetyl-CoA synthetase (AMP-forming) [KO:K01895] [EC:6.2.1.1]
b4467  glcF; glycolate dehydrogenase, putative iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
b4468  glcE; glycolate dehydrogenase, putative FAD-binding subunit [KO:K11472] [EC:1.1.99.14]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
eco00010  Glycolysis / Gluconeogenesis
eco00020  Citrate cycle (TCA cycle)
eco00030  Pentose phosphate pathway
eco00053  Ascorbate and aldarate metabolism
eco00071  Fatty acid degradation
eco00230  Purine metabolism
eco00250  Alanine, aspartate and glutamate metabolism
eco00260  Glycine, serine and threonine metabolism
eco00270  Cysteine and methionine metabolism
eco00620  Pyruvate metabolism
eco00710  Carbon fixation by Calvin cycle
eco00750  Vitamin B6 metabolism
eco00910  Nitrogen metabolism
KO pathway
ko00630   

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