KEGG   PATHWAY: egz03015
Entry
egz03015                    Pathway                                
Name
mRNA surveillance pathway - Egretta garzetta (little egret)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
egz03015  mRNA surveillance pathway
egz03015

Other DBs
GO: 0071028
Organism
Egretta garzetta (little egret) [GN:egz]
Gene
104133498  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104124265  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
104127082  nuclear cap-binding protein subunit 2-like [KO:K12883]
104124092  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
104126357  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
104133361  uncharacterized protein LOC104133361 [KO:K12876]
104131482  MAGOH; protein mago nashi homolog [KO:K12877]
104130624  protein CASC3-like [KO:K14323]
104127664  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104131682  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104133244  PNN; pinin [KO:K13114]
104135924  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
104131198  ALYREF; THO complex subunit 4 [KO:K12881]
104133101  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
104122203  GLE1; nucleoporin GLE1 [KO:K18723]
104133276  NXT2; NTF2-related export protein 2 [KO:K14285]
104134960  SRRM1; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1 [KO:K13171]
104135255  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104132861  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
104133075  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
104127044  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
104130277  NUDT21; LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
104132948  CPSF6; cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
104125245  CPSF7; cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
104128693  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
104127809  PAPOLA; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
104129563  CLP1; LOW QUALITY PROTEIN: polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
104129415  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 [KO:K14400]
104135341  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
104127141  CPSF3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
104132834  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
104132635  CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
104126070  pre-mRNA 3'-end-processing factor FIP1-like [KO:K14405]
104129403  FIP1L1; LOW QUALITY PROTEIN: pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
104126892  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
104126673  WDR82; WD repeat-containing protein 82 [KO:K14962]
104135633  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104122715  PPP1CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104133383  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
104132187  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
104129942  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
104133514  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
104133525  SYMPK; LOW QUALITY PROTEIN: symplekin [KO:K06100]
104122027  MSI2; RNA-binding protein Musashi homolog 2 [KO:K14411]
104129857  MSI1; RNA-binding protein Musashi homolog 1 [KO:K14411]
104128292  DAZAP1; DAZ-associated protein 1 [KO:K14411]
104134978  PABPC4; polyadenylate-binding protein 4 [KO:K13126]
104124961  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
104125879  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
104135955  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
104126957  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
104129801  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104135773  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
104135846  SMG1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
104129706  SMG7; protein SMG7 isoform X1 [KO:K14409]
104123077  SMG5; protein SMG5 [KO:K11125]
104131936  SMG6; LOW QUALITY PROTEIN: telomerase-binding protein EST1A [KO:K11124] [EC:3.1.-.-]
104133477  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104135437  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104123525  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
104123264  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
104133589  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
104124969  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
104133304  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
104131262  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
104125229  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
104132838  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
104125538  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
104124511  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
104128769  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
104131145  HBS1L; HBS1-like protein [KO:K14416]
104131613  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
egz03013  Nucleocytoplasmic transport
egz03018  RNA degradation
egz03040  Spliceosome
KO pathway
ko03015   
LinkDB

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