KEGG   PATHWAY: elu00260
Entry
elu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli UM146
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
elu00260  Glycine, serine and threonine metabolism
elu00260

Module
elu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:elu00260]
elu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:elu00260]
elu_M00555  Betaine biosynthesis, choline => betaine [PATH:elu00260]
elu_M00621  Glycine cleavage system [PATH:elu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli UM146 [GN:elu]
Gene
UM146_20235  aspartate kinase III [KO:K00928] [EC:2.7.2.4]
UM146_22785  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
UM146_19940  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
UM146_17270  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
UM146_22790  homoserine kinase [KO:K00872] [EC:2.7.1.39]
UM146_22795  threonine synthase [KO:K01733] [EC:4.2.3.1]
UM146_13300  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
UM146_03965  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
UM146_12160  putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
UM146_17935  2-ketoaldonate reductase/glyoxylate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
UM146_14790  glycerate kinase II [KO:K00865] [EC:2.7.1.165]
UM146_00730  glycerate kinase I [KO:K00865] [EC:2.7.1.165]
UM146_13880  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
UM146_22745  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
UM146_18225  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
UM146_01965  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
UM146_02375  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
UM146_13015  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
UM146_22700  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
UM146_09295  3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
UM146_18250  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
UM146_18245  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
UM146_02010  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
UM146_02000  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
UM146_20425  putative dihydrolipoyl dehydrogenase, E3 component (lpd-like) protein [KO:K00382] [EC:1.8.1.4]
UM146_23385  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
UM146_02005  glycine cleavage system protein H [KO:K02437]
UM146_03790  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
UM146_15745  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
UM146_15740  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
UM146_02580  L-serine deaminase II [KO:K01752] [EC:4.3.1.17]
UM146_08100  L-serine deaminase I [KO:K01752] [EC:4.3.1.17]
UM146_00770  L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]
UM146_19005  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
UM146_00745  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
UM146_04770  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
UM146_21995  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
UM146_02225  putative racemase [KO:K25316] [EC:5.1.1.10]
UM146_10480  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
UM146_10475  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
elu00010  Glycolysis / Gluconeogenesis
elu00020  Citrate cycle (TCA cycle)
elu00230  Purine metabolism
elu00250  Alanine, aspartate and glutamate metabolism
elu00270  Cysteine and methionine metabolism
elu00290  Valine, leucine and isoleucine biosynthesis
elu00300  Lysine biosynthesis
elu00330  Arginine and proline metabolism
elu00460  Cyanoamino acid metabolism
elu00470  D-Amino acid metabolism
elu00564  Glycerophospholipid metabolism
elu00600  Sphingolipid metabolism
elu00620  Pyruvate metabolism
elu00630  Glyoxylate and dicarboxylate metabolism
elu00640  Propanoate metabolism
elu00680  Methane metabolism
elu00860  Porphyrin metabolism
elu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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