KEGG   PATHWAY: elu00230
Entry
elu00230                    Pathway                                
Name
Purine metabolism - Escherichia coli UM146
Class
Metabolism; Nucleotide metabolism
Pathway map
elu00230  Purine metabolism
elu00230

Module
elu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:elu00230]
elu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:elu00230]
elu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:elu00230]
elu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:elu00230]
elu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:elu00230]
elu_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:elu00230]
elu_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:elu00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli UM146 [GN:elu]
Gene
UM146_01135  nudF; ADP-ribose pyrophosphatase NudF [KO:K01515] [EC:3.6.1.13 3.6.1.-]
UM146_17040  nudE; ADP-ribose diphosphatase NudE [KO:K08312] [EC:3.6.1.-]
UM146_22675  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
UM146_16955  putative mutase [KO:K01839] [EC:5.4.2.7]
UM146_14115  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
UM146_11025  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
UM146_05250  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
UM146_16635  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
UM146_04225  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
UM146_07910  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
UM146_03935  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
UM146_04230  phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
UM146_14750  phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
UM146_14745  phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
UM146_04285  phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
UM146_11660  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
UM146_16630  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
UM146_15015  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
UM146_14960  ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor [KO:K11751] [EC:3.1.3.5 3.6.1.45]
UM146_02835  surE; stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
UM146_14230  UMP phosphatase [KO:K02566] [EC:3.1.3.5]
UM146_17050  putative hydrolase [KO:K20881] [EC:3.1.3.-]
UM146_14975  inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
UM146_04590  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
UM146_22680  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
UM146_15410  hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
UM146_03735  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
UM146_23430  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
UM146_04180  inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
UM146_04115  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
UM146_22740  NTPase [KO:K01529] [EC:3.6.1.73]
UM146_01745  putative deoxyribonucleotide triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
UM146_16025  xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
UM146_02190  xanthine dehydrogenase subunit XdhA [KO:K00087] [EC:1.17.1.4]
UM146_02185  xanthine dehydrogenase subunit XdhB [KO:K13479] [EC:1.17.1.4]
UM146_02180  xanthine dehydrogenase subunit XdhC [KO:K13480]
UM146_04185  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
UM146_23305  guanosine 5'-monophosphate oxidoreductase [KO:K00364] [EC:1.7.1.7]
UM146_02105  guanine deaminase [KO:K01487] [EC:3.5.4.3]
UM146_18395  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
UM146_03205  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
UM146_05635  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
UM146_05630  nrdB; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
UM146_03200  nrdF; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
UM146_21450  anaerobic ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
UM146_23615  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
UM146_05360  hypothetical protein [KO:K08722] [EC:3.1.3.89]
UM146_03330  hypothetical protein [KO:K06952] [EC:3.1.3.89]
UM146_18405  bifunctional (p)ppGpp synthetase II/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
UM146_19030  guanosine pentaphosphate phosphohydrolase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
UM146_04215  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
UM146_02650  relA; GDP/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
UM146_19155  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
UM146_21125  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
UM146_09040  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
UM146_07225  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
UM146_02590  hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
UM146_18535  cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
UM146_21350  cpdB; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein [KO:K01119] [EC:3.1.4.16 3.1.3.6]
UM146_14990  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
UM146_02665  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
UM146_01145  cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
UM146_23040  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
UM146_02805  adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
UM146_02800  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
UM146_02795  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
UM146_07350  hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
UM146_14800  allantoinase [KO:K01466] [EC:3.5.2.5]
UM146_14780  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
UM146_14785  hypothetical protein [KO:K14977] [EC:3.5.3.26]
UM146_14830  ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
UM146_14775  ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
UM146_15690  putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
UM146_14755  carbamate kinase [KO:K00926] [EC:2.7.2.2]
UM146_21515  carbamate kinase [KO:K00926] [EC:2.7.2.2]
UM146_02150  carbamate kinase [KO:K00926] [EC:2.7.2.2]
UM146_19350  carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
elu00030  Pentose phosphate pathway
elu00220  Arginine biosynthesis
elu00250  Alanine, aspartate and glutamate metabolism
elu00260  Glycine, serine and threonine metabolism
elu00340  Histidine metabolism
elu00630  Glyoxylate and dicarboxylate metabolism
elu00730  Thiamine metabolism
elu00740  Riboflavin metabolism
elu00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system