KEGG   PATHWAY: eok00230
Entry
eok00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O55:H7 CB9615 (EPEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
eok00230  Purine metabolism
eok00230

Module
eok_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:eok00230]
eok_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:eok00230]
eok_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:eok00230]
eok_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:eok00230]
eok_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eok00230]
eok_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:eok00230]
eok_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:eok00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O55:H7 CB9615 (EPEC) [GN:eok]
Gene
G2583_0053  apaH; Bis(5-nucleosyl)-tetraphosphatase, symmetrical [KO:K01525] [EC:3.6.1.41]
G2583_0108  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
G2583_0129  hpt; Hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
G2583_0164  dgt; Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
G2583_0274  gpt; Xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
G2583_0376  yagR; Putative xanthine dehydrogenase yagR molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
G2583_0377  yagS; FAD binding domain in molybdopterin dehydrogenase [KO:K11178] [EC:1.17.1.4]
G2583_0378  yagT; Putative xanthine dehydrogenase yagT iron-sulfur-binding subunit precursor [KO:K13483]
G2583_0428  yahI; Carbamate kinase family protein [KO:K00926] [EC:2.7.2.2]
G2583_0499  yaiE; UPF0345 protein yaiE [KO:K09913] [EC:2.4.2.1 2.4.2.2]
G2583_0581  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
G2583_0586  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
G2583_0589  gsk; Inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
G2583_0592  ushA; UDP-sugar hydrolase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
G2583_0625  allA; Ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
G2583_0632  allB; Dihydroorotase-like cyclic amidohydrolase [KO:K01466] [EC:3.5.2.5]
G2583_0635  ylbA; hypothetical protein [KO:K14977] [EC:3.5.3.26]
G2583_0636  allC; Allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
G2583_0637  allD; Ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
G2583_0641  ybcF; Carbamate kinase [KO:K00926] [EC:2.7.2.2]
G2583_0642  purK; Phosphoribosylaminoimidazole carboxylase, ATPase subunit [KO:K01589] [EC:6.3.4.18]
G2583_0643  purE; Phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
G2583_0836  nagD; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
G2583_0849  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
G2583_1407  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
G2583_1478  prs; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
G2583_2017  add; Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
G2583_2301  purT; Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
G2583_2420  yedX; Transthyretin-like protein precursor [KO:K07127] [EC:3.5.2.17]
G2583_2491  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
G2583_2772  nrdA; Ribonucleoside-diphosphate reductase, alpha subunit [KO:K00525] [EC:1.17.4.1]
G2583_2773  nrdB; Ribonucleoside-diphosphate reductase 1, beta subunit, B2 [KO:K00526] [EC:1.17.4.1]
G2583_2828  yfbR; 5'-nucleotidase yfbR [KO:K08722] [EC:3.1.3.89]
G2583_2849  purF; Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
G2583_2999  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
G2583_3022  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
G2583_3023  purN; Phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
G2583_3025  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
G2583_3031  guaA; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
G2583_3032  guaB; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
G2583_3043  ndk; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
G2583_3088  purL; Phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
G2583_3176  yfiH; hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
G2583_3323  nrdE; Ribonucleoside-diphosphate reductase, alpha subunit [KO:K00525] [EC:1.17.4.1]
G2583_3324  nrdF; Ribonucleoside-diphosphate reductase 2 subunit beta [KO:K00526] [EC:1.17.4.1]
G2583_3392  surE; Multifunctional protein surE [Includes: 5'/3'-nucleotidase (Nucleoside monophosphate phosphohydrolase)] [KO:K03787] [EC:3.1.3.5 3.1.3.6]
G2583_3398  cysC; Adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
G2583_3399  cysN; Sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
G2583_3400  cysD; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
G2583_3433  mazG; Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
G2583_3436  relA; GTP diphosphokinase [KO:K00951] [EC:2.7.6.5]
G2583_3448  ygdH; hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
G2583_3520  xdhA; Xanthine dehydrogenase [KO:K00087] [EC:1.17.1.4]
G2583_3521  xdhB; Xanthine dehydrogenase FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
G2583_3522  xdhC; Xanthine dehydrogenase iron-sulfur-binding subunit [KO:K13480]
G2583_3528  yqeA; Carbamate kinase arcC-like protein [KO:K00926] [EC:2.7.2.2]
G2583_3537  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
G2583_3613  rdgB; Nucleoside-triphosphatase rdgB [KO:K01519] [EC:3.6.1.66]
G2583_3758  cpdA; cyclic 3,5-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
G2583_3760  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
G2583_4093  nudE; ADP compounds hydrolase NudE [KO:K08312] [EC:3.6.1.-]
G2583_4095  yrfG; Putative phosphatase [KO:K20881] [EC:3.1.3.-]
G2583_4384  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
G2583_4386  spoT; Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase (Penta-phosphate guanosine-3-pyrophosphohydrolase) ((ppGpp)ase) [KO:K01139] [EC:2.7.6.5 3.1.7.2]
G2583_4456  ade; Adenine deaminase [KO:K01486] [EC:3.5.4.2]
G2583_4572  gpp; Guanosine-5-triphosphate,3-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
G2583_4602  cyaA; Adenylate cyclase [KO:K05851] [EC:4.6.1.1]
G2583_4823  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
G2583_4824  purH; IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
G2583_5004  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
G2583_5043  cpdB; 2,3-cyclic-nucleotide 2-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
G2583_5067  nrdD; Anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
G2583_5180  yfdR; hypothetical protein [KO:K06952] [EC:3.1.3.89]
G2583_5243  deoB; Phosphopentomutase [KO:K01839] [EC:5.4.2.7]
G2583_5244  deoD; Purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
G2583_5253  yjjX; conserved hypothetical protein [KO:K01529]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
eok00030  Pentose phosphate pathway
eok00220  Arginine biosynthesis
eok00250  Alanine, aspartate and glutamate metabolism
eok00260  Glycine, serine and threonine metabolism
eok00340  Histidine metabolism
eok00630  Glyoxylate and dicarboxylate metabolism
eok00730  Thiamine metabolism
eok00740  Riboflavin metabolism
eok00790  Folate biosynthesis
KO pathway
ko00230   

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