KEGG   PATHWAY: eum00260
Entry
eum00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eum00260  Glycine, serine and threonine metabolism
eum00260

Module
eum_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eum00260]
eum_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eum00260]
eum_M00555  Betaine biosynthesis, choline => betaine [PATH:eum00260]
eum_M00621  Glycine cleavage system [PATH:eum00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli O17:K52:H18 UMN026 (ExPEC) [GN:eum]
Gene
ECUMN_4557  lysC; aspartokinase III [KO:K00928] [EC:2.7.2.4]
ECUMN_0002  thrA; fused aspartokinase I; homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
ECUMN_4470  metL; fused aspartokinase II; homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
ECUMN_3897  asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding [KO:K00133] [EC:1.2.1.11]
ECUMN_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
ECUMN_0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
ECUMN_1065  ltaE; L-allo-threonine aldolase, PLP-dependent [KO:K01620] [EC:4.1.2.48]
ECUMN_2871  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECUMN_1207  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECUMN_4065  tiaE; 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECUMN_0554  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
ECUMN_3606  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
ECUMN_0839  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
ECUMN_5026  ytjC; phosphoglyceromutase 2, co-factor independent [KO:K15634] [EC:5.4.2.11]
ECUMN_4129  gpmI; phosphoglycero mutase III, cofactor-independent [KO:K15633] [EC:5.4.2.12]
ECUMN_3254  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ECUMN_1100  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
ECUMN_5012  serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ECUMN_1806  ydfG; L-allo-threonine dehydrogenase, NAD(P)-binding [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ECUMN_4134  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
ECUMN_4133  tdh; threonine 3-dehydrogenase, NAD(P)-binding [KO:K00060] [EC:1.1.1.103]
ECUMN_3244  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
ECUMN_3246  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
ECUMN_0113  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
ECUMN_3245  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
ECUMN_2911  pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) [KO:K00998] [EC:2.7.8.8]
ECUMN_0349  betA; choline dehydrogenase, a flavoprotein [KO:K00108] [EC:1.1.99.1]
ECUMN_0350  betB; betaine aldehyde dehydrogenase, NAD-dependent [KO:K00130] [EC:1.2.1.8]
ECUMN_2106  sdaA; L-serine deaminase I [KO:K01752] [EC:4.3.1.17]
ECUMN_3126  sdaB; L-serine deaminase II [KO:K01752] [EC:4.3.1.17]
ECUMN_3596  tdcG; L-serine dehydratase 3 [KO:K01752] [EC:4.3.1.17]
ECUMN_4298  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
ECUMN_3601  tdcB; catabolic threonine dehydratase, PLP-dependent [KO:K01754] [EC:4.3.1.19]
ECUMN_2695  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
ECUMN_3168  putative racemase [KO:K25316] [EC:5.1.1.10]
ECUMN_1559  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
ECUMN_1560  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eum00010  Glycolysis / Gluconeogenesis
eum00020  Citrate cycle (TCA cycle)
eum00230  Purine metabolism
eum00250  Alanine, aspartate and glutamate metabolism
eum00270  Cysteine and methionine metabolism
eum00290  Valine, leucine and isoleucine biosynthesis
eum00300  Lysine biosynthesis
eum00330  Arginine and proline metabolism
eum00460  Cyanoamino acid metabolism
eum00470  D-Amino acid metabolism
eum00564  Glycerophospholipid metabolism
eum00600  Sphingolipid metabolism
eum00620  Pyruvate metabolism
eum00630  Glyoxylate and dicarboxylate metabolism
eum00640  Propanoate metabolism
eum00680  Methane metabolism
eum00860  Porphyrin metabolism
eum00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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