KEGG   PATHWAY: eum00630
Entry
eum00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Class
Metabolism; Carbohydrate metabolism
Pathway map
eum00630  Glyoxylate and dicarboxylate metabolism
eum00630

Module
eum_M00012  Glyoxylate cycle [PATH:eum00630]
eum_M00621  Glycine cleavage system [PATH:eum00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli O17:K52:H18 UMN026 (ExPEC) [GN:eum]
Gene
ECUMN_0113  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
ECUMN_0115  acnB; bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ECUMN_0376  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
ECUMN_0548  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
ECUMN_0549  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
ECUMN_0550  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
ECUMN_0554  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
ECUMN_0798  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
ECUMN_0814  [KO:K04835] [EC:4.3.1.2]
ECUMN_0815  [KO:K19268] [EC:5.4.99.1]
ECUMN_0817  [KO:K01846] [EC:5.4.99.1]
ECUMN_1207  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECUMN_1529  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
ECUMN_1578  acnA; aconitate hydratase 1 [KO:K27802]
ECUMN_1663  aldA; aldehyde dehydrogenase A, NAD-linked [KO:K07248] [EC:1.2.1.22 1.2.1.21]
ECUMN_2021  katE; hydroperoxidase HPII(III) (catalase) [KO:K03781] [EC:1.11.1.6]
ECUMN_2090  yeaU; putative tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
ECUMN_2147  eda; multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ECUMN_2562  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECUMN_2702  oxc; putative oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
ECUMN_2703  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
ECUMN_2871  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECUMN_3128  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
ECUMN_3172  yqeF; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECUMN_3244  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
ECUMN_3245  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
ECUMN_3246  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
ECUMN_3261  yliK; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
ECUMN_3451  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
ECUMN_3453  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
ECUMN_3454  glcE; glycolate oxidase FAD binding subunit [KO:K11472] [EC:1.1.99.14]
ECUMN_3455  glcD; glycolate oxidase subunit, FAD-linked [KO:K00104] [EC:1.1.99.14]
ECUMN_3544  ttdA; L-tartrate dehydratase, alpha subunit [KO:K03779] [EC:4.2.1.32]
ECUMN_3545  ttdB; L-tartrate dehydratase, beta subunit [KO:K03780] [EC:4.2.1.32]
ECUMN_3606  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
ECUMN_3607  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
ECUMN_3710  mdh; malate dehydrogenase, NAD(P)-binding [KO:K00024] [EC:1.1.1.37]
ECUMN_3843  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
ECUMN_4065  tiaE; 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECUMN_4393  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ECUMN_4422  fdoI; formate dehydrogenase-O, cytochrome b556 subunit [KO:K00127]
ECUMN_4423  fdoH; formate dehydrogenase-O, Fe-S subunit [KO:K00124]
ECUMN_4424  fdoG; formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
ECUMN_4540  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
ECUMN_4541  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
ECUMN_4605  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
eum00010  Glycolysis / Gluconeogenesis
eum00020  Citrate cycle (TCA cycle)
eum00030  Pentose phosphate pathway
eum00053  Ascorbate and aldarate metabolism
eum00071  Fatty acid degradation
eum00230  Purine metabolism
eum00250  Alanine, aspartate and glutamate metabolism
eum00260  Glycine, serine and threonine metabolism
eum00270  Cysteine and methionine metabolism
eum00620  Pyruvate metabolism
eum00710  Carbon fixation by Calvin cycle
eum00750  Vitamin B6 metabolism
eum00910  Nitrogen metabolism
KO pathway
ko00630   

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