KEGG   PATHWAY: eum00230
Entry
eum00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
eum00230  Purine metabolism
eum00230

Module
eum_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:eum00230]
eum_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:eum00230]
eum_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:eum00230]
eum_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:eum00230]
eum_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eum00230]
eum_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:eum00230]
eum_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:eum00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O17:K52:H18 UMN026 (ExPEC) [GN:eum]
Gene
ECUMN_0051  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
ECUMN_0102  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
ECUMN_0122  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ECUMN_0158  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
ECUMN_0304  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ECUMN_0315  yagR; putative oxidoreductase with molybdenum-binding domain [KO:K11177] [EC:1.17.1.4]
ECUMN_0316  yagS; putative oxidoreductase with FAD-binding domain [KO:K11178] [EC:1.17.1.4]
ECUMN_0361  yahI; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECUMN_0429  yaiE; conserved hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ECUMN_0508  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ECUMN_0513  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
ECUMN_0516  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
ECUMN_0519  ushA; bifunctional UDP-sugar hydrolase and 5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ECUMN_0546  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ECUMN_0552  allB; allantoinase [KO:K01466] [EC:3.5.2.5]
ECUMN_0555  ylbA; conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
ECUMN_0556  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ECUMN_0557  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ECUMN_0561  ybcF; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECUMN_0562  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
ECUMN_0563  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
ECUMN_0760  nagD; NMP phosphatase [KO:K02566] [EC:3.1.3.5]
ECUMN_0774  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ECUMN_0861  yfdR; conserved hypothetical protein; CPS-53 (KpLE1) prophage [KO:K06952] [EC:3.1.3.89]
ECUMN_1375  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ECUMN_1504  prsA; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
ECUMN_1913  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ECUMN_2146  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ECUMN_2261  yedX; conserved hypothetical protein [KO:K07127] [EC:3.5.2.17]
ECUMN_2320  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ECUMN_2571  nrdA; ribonucleoside diphosphate reductase 1, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECUMN_2572  nrdB; ribonucleoside diphosphate reductase 1, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
ECUMN_2630  yfbR; deoxyribonucleoside 5'-monophosphatase [KO:K08722] [EC:3.1.3.89]
ECUMN_2652  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ECUMN_2789  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
ECUMN_2813  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
ECUMN_2814  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
ECUMN_2816  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECUMN_2823  guaA; GMP synthetase (glutamine aminotransferase) [KO:K01951] [EC:6.3.5.2]
ECUMN_2824  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
ECUMN_2838  ndk; multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
ECUMN_2877  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
ECUMN_2920  yfiH; conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ECUMN_3001  nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECUMN_3002  nrdF; ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
ECUMN_3068  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ECUMN_3074  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
ECUMN_3075  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
ECUMN_3076  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
ECUMN_3112  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
ECUMN_3113  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
ECUMN_3124  ygdH; conserved hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ECUMN_3209  xdhA; xanthine dehydrogenase, molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
ECUMN_3210  xdhB; xanthine dehydrogenase, FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
ECUMN_3211  xdhC; xanthine dehydrogenase, Fe-S binding subunit [KO:K13480]
ECUMN_3217  yqeA; amino acid (carbamate) kinase [KO:K00926] [EC:2.7.2.2]
ECUMN_3226  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
ECUMN_3306  yggV; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
ECUMN_3517  cpdA; cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
ECUMN_3519  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ECUMN_3837  yhfW; putative mutase [KO:K01839] [EC:5.4.2.7]
ECUMN_3855  nudE; ADP-ribose diphosphatase [KO:K08312] [EC:3.6.1.-]
ECUMN_3857  yrfG; putative hydrolase [KO:K20881] [EC:3.1.3.-]
ECUMN_4164  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
ECUMN_4166  spoT; bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ECUMN_4192  ade; cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
ECUMN_4303  gpp; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECUMN_4330  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
ECUMN_4529  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
ECUMN_4530  purH; fused IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ECUMN_4710  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ECUMN_4750  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ECUMN_4771  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
ECUMN_5007  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ECUMN_5008  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ECUMN_5025  yjjX; thiamin metabolism associated protein [KO:K01529]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
eum00030  Pentose phosphate pathway
eum00220  Arginine biosynthesis
eum00250  Alanine, aspartate and glutamate metabolism
eum00260  Glycine, serine and threonine metabolism
eum00340  Histidine metabolism
eum00630  Glyoxylate and dicarboxylate metabolism
eum00730  Thiamine metabolism
eum00740  Riboflavin metabolism
eum00790  Folate biosynthesis
KO pathway
ko00230   

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