KEGG   PATHWAY: gaf00330
Entry
gaf00330                    Pathway                                
Name
Arginine and proline metabolism - Gambusia affinis (western mosquitofish)
Class
Metabolism; Amino acid metabolism
Pathway map
gaf00330  Arginine and proline metabolism
gaf00330

Module
gaf_M00015  Proline biosynthesis, glutamate => proline [PATH:gaf00330]
gaf_M00047  Creatine pathway [PATH:gaf00330]
gaf_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:gaf00330]
gaf_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:gaf00330]
gaf_M00970  Proline degradation, proline => glutamate [PATH:gaf00330]
gaf_M00972  Proline metabolism [PATH:gaf00330]
Other DBs
GO: 0006525 0006560
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122841175  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
122839102  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
122846137  ckba; creatine kinase, brain a isoform X1 [KO:K00933] [EC:2.7.3.2]
122825596  creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
122819332  ckmt2a; creatine kinase, mitochondrial 2a (sarcomeric) [KO:K00933] [EC:2.7.3.2]
122826897  creatine kinase U-type, mitochondrial-like [KO:K00933] [EC:2.7.3.2]
122835859  ckmt1; creatine kinase, mitochondrial 1 isoform X1 [KO:K00933] [EC:2.7.3.2]
122832890  ckmb; creatine kinase, muscle b [KO:K27382] [EC:2.7.3.2]
122844706  ckma; creatine kinase, muscle a [KO:K27382] [EC:2.7.3.2]
122845617  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
122834646  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
122844452  sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
122824825  amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
122824085  aoc1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
122829914  smox; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
122844550  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
122830675  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
122833113  aldehyde dehydrogenase family 3 member A2-like isoform X1 [KO:K00128] [EC:1.2.1.3]
122821381  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
122838667  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122841585  aldh9a1b; LOW QUALITY PROTEIN: 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
122838345  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
122843118  cndp2; LOW QUALITY PROTEIN: cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
122844469  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
122844840  sat2b; diamine acetyltransferase 2b isoform X1 [KO:K00657] [EC:2.3.1.57]
122824470  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
122820103  thialysine N-epsilon-acetyltransferase-like [KO:K00657] [EC:2.3.1.57]
122847269  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
122840321  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
122833948  agmat; agmatinase, mitochondrial [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
122827934  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
122845849  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
122823041  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
122823781  oat; ornithine aminotransferase, mitochondrial isoform X1 [KO:K00819] [EC:2.6.1.13]
122837987  pycr3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
122821912  pycr1a; pyrroline-5-carboxylate reductase 1a [KO:K00286] [EC:1.5.1.2]
122829644  pycr1b; pyrroline-5-carboxylate reductase 1b [KO:K00286] [EC:1.5.1.2]
122847162  prodha; proline dehydrogenase 1, mitochondrial [KO:K00318] [EC:1.5.5.2]
122828662  prodhb; proline dehydrogenase 1, mitochondrial [KO:K00318] [EC:1.5.5.2]
122834530  aldh4a1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
122823380  aldh18a1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
122842706  delta-1-pyrroline-5-carboxylate synthase-like isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
122830415  lap3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
122842387  p4ha1b; prolyl 4-hydroxylase subunit alpha-1b isoform X1 [KO:K00472] [EC:1.14.11.2]
122844661  p4ha2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
122833096  p4ha3; prolyl 4-hydroxylase subunit alpha-3 [KO:K00472] [EC:1.14.11.2]
122823039  prolyl 4-hydroxylase subunit alpha-1-like isoform X1 [KO:K00472] [EC:1.14.11.2]
122823377  prodh2; hydroxyproline dehydrogenase isoform X1 [KO:K11394] [EC:1.5.5.3]
122830292  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
122842394  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122843286  got2b; glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
122830294  hoga1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
122828275  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
122825837  trans-L-3-hydroxyproline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
gaf00020  Citrate cycle (TCA cycle)
gaf00220  Arginine biosynthesis
gaf00250  Alanine, aspartate and glutamate metabolism
gaf00260  Glycine, serine and threonine metabolism
gaf00270  Cysteine and methionine metabolism
gaf00310  Lysine degradation
gaf00410  beta-Alanine metabolism
gaf00470  D-Amino acid metabolism
gaf00480  Glutathione metabolism
gaf00630  Glyoxylate and dicarboxylate metabolism
gaf00650  Butanoate metabolism
gaf00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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