KEGG PATHWAY: gga04216

PATHWAY: gga04216

Entry

gga04216                    Pathway

Name

Ferroptosis - Gallus gallus (chicken)

Description

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.

Class

Cellular Processes; Cell growth and death

Pathway map

gga04216

Ferroptosis

Other DBs

GO:

0097707

Organism

Gallus gallus (chicken) [GN:gga]

Gene

374006

SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]

374056

GPX4; phospholipid hydroperoxide glutathione peroxidase isoform C [KO:K05361] [EC:1.11.1.12]

395498

VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]

395970

FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.2]

396191

TFR2; transferrin receptor protein 1 [KO:K06503]

396241

TF; ovotransferrin precursor [KO:K14736]

396287

HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]

396452

PRNP; major prion protein homolog preproprotein [KO:K05634]

415961

ATG7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]

416324

ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X3 [KO:K01897] [EC:6.2.1.3]

418109

CGTL; cystine/glutamate transporter isoform X1 [KO:K13869]

418293

LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]

418581

CYBB; cytochrome b-245 beta chain [KO:K21421] [EC:1.-.-.-]

419142

MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]

421504

MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C isoform X1 [KO:K10435]

421784

ATG5; autophagy protein 5 [KO:K08339]

421894

GCLC; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]

422345

ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]

422547

ACSL1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]

423615

NCOA4; nuclear receptor coactivator 4 [KO:K09289]

423896

ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]

423984

SLC40A1; solute carrier family 40 member 1 [KO:K14685]

424275

STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]

424492

GCLM; glutamate--cysteine ligase regulatory subunit [KO:K11205]

424810

ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]

426023

[KO:K13162]

426793

VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]

427559

MAP1LC3B2; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]

428135

GSS; glutathione synthetase [KO:K21456] [EC:6.3.2.3]

428731

SLC7A11; cystine/glutamate transporter isoform X2 [KO:K13869]

429550

SLC39A14; zinc transporter ZIP14 isoform X5 [KO:K14720]

430411

SLC39A8; zinc transporter ZIP8 isoform X1 [KO:K14714]

751817

SLC11A2; natural resistance-associated macrophage protein 2 isoform 2 [KO:K21398]

771940

CP; ceruloplasmin [KO:K13624] [EC:1.16.3.1]

Compound

C00010

CoA

C00024

Acetyl-CoA

C00025

L-Glutamate

C00027

Hydrogen peroxide

C00032

Heme

C00051

Glutathione

C00097

L-Cysteine

C00127

Glutathione disulfide

C00129

Isopentenyl diphosphate

C00219

Arachidonate

C00356

(S)-3-Hydroxy-3-methylglutaryl-CoA

C00418

(R)-Mevalonate

C00491

L-Cystine

C00669

gamma-L-Glutamyl-L-cysteine

C02249

Arachidonyl-CoA

C02477

alpha-Tocopherol

C11378

Ubiquinone-10

C14818

Fe2+

C14819

Fe3+

C16170

(7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA

C16527

Adrenic acid

C16844

Hydroxyl radical

C21478

Erastin

C21479

RSL3

C21480

1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

C21481

1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine

C21482

1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

C21483

1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

C21484

1-Octadecanoyl-sn-glycero-3-phosphoethanolamine

D00448

Sulfasalazine (USP/INN)

D08524

Sorafenib (USAN/INN)

Reference

PMID:26775689

Authors

Conrad M, Angeli JP, Vandenabeele P, Stockwell BR

Title

Regulated necrosis: disease relevance and therapeutic opportunities.

Journal

Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6

Reference

PMID:26653790

Authors

Yang WS, Stockwell BR

Title

Ferroptosis: Death by Lipid Peroxidation.

Journal

Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014

Reference

PMID:27842066

Authors

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H

Title

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Journal

Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238

Reference

PMID:27842067

Authors

D'Herde K, Krysko DV

Title

Ferroptosis: Oxidized PEs trigger death.

Journal

Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261

Reference

PMID:28082232

Authors

Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S

Title

Ferroptosis and cell death mechanisms in Parkinson's disease.

Journal

Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004

Reference

PMID:26725301

Authors

Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y

Title

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.

Journal

Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012

Reference

PMID:26794443

Authors

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D

Title

Ferroptosis: process and function.

Journal

Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158

Reference

PMID:27791175

Authors

Murphy ME

Title

Ironing out how p53 regulates ferroptosis.

Journal

Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113

Reference

PMID:28129536

Authors

Muckenthaler MU, Rivella S, Hentze MW, Galy B

Title

A Red Carpet for Iron Metabolism.

Journal

Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034

Reference

PMID:27860262

Authors

Yu H, Guo P, Xie X, Wang Y, Chen G

Title

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.

Journal

J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008

Reference

PMID:27314071

Authors

Wang SJ, Ou Y, Jiang L, Gu W

Title

Ferroptosis: A missing puzzle piece in the p53 blueprint?

Journal

Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581

Reference

PMID:27048822

Authors

Cao JY, Dixon SJ

Title

Mechanisms of ferroptosis.

Journal

Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1

Reference

PMID:26436293

Authors

Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW

Title

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

Journal

Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308

Reference

PMID:28066232

Authors

Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ

Title

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.

Journal

Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308

Reference

PMID:26405158

Authors

Kwon MY, Park E, Lee SJ, Chung SW

Title

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.

Journal

Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162

Reference

PMID:22632964

Authors

Reed JC, Pellecchia M

Title

Ironing out cell death mechanisms.

Journal

Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009

Related
pathway

gga00480

Glutathione metabolism

gga00900

Terpenoid backbone biosynthesis

KO pathway

ko04216

DBGET integrated database retrieval system