Entry Name Protein export - Homo sapiens (human)
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Other DBs Organism Homo sapiens (human) [GN:
hsa ]
Gene 10952 SEC61B; SEC61 translocon subunit beta [KO:K09481 ]
11231 SEC63; SEC63 homolog, protein translocation regulator [KO:K09540 ]
196294 IMMP1L; inner mitochondrial membrane peptidase subunit 1 [KO:K09647 ] [EC:3.4.21.-]
23480 SEC61G; SEC61 translocon subunit gamma [KO:K07342 ]
28972 SPCS1; signal peptidase complex subunit 1 [KO:K12946 ] [EC:3.4.-.-]
29927 SEC61A1; SEC61 translocon subunit alpha 1 [KO:K10956 ]
439 GET3; guided entry of tail-anchored proteins factor 3, ATPase [KO:K01551 ] [EC:7.3.2.7 7.3.-.-]
5018 OXA1L; OXA1L mitochondrial inner membrane protein [KO:K03217 ]
51608 GET4; guided entry of tail-anchored proteins factor 4 [KO:K23387 ]
55176 SEC61A2; SEC61 translocon subunit alpha 2 [KO:K10956 ]
60559 SPCS3; signal peptidase complex subunit 3 [KO:K12948 ] [EC:3.4.-.-]
6449 SGTA; small glutamine rich tetratricopeptide repeat co-chaperone alpha [KO:K16365 ]
6726 SRP9; signal recognition particle 9 [KO:K03109 ]
6727 SRP14; signal recognition particle 14 [KO:K03104 ]
6728 SRP19; signal recognition particle 19 [KO:K03105 ]
6730 SRP68; signal recognition particle 68 [KO:K03107 ]
6731 SRP72; signal recognition particle 72 [KO:K03108 ]
6734 SRPRA; SRP receptor subunit alpha [KO:K13431 ]
7095 SEC62; SEC62 homolog, preprotein translocation factor [KO:K12275 ]
7485 GET1; guided entry of tail-anchored proteins factor 1 [KO:K22384 ]
83943 IMMP2L; inner mitochondrial membrane peptidase subunit 2 [KO:K09648 ] [EC:3.4.21.-]
9789 SPCS2; signal peptidase complex subunit 2 [KO:K12947 ] [EC:3.4.-.-]
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal KO pathway
