KEGG   Homo sapiens (human): 1400
Entry
1400              CDS       T01001                                 
Symbol
CRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3
Name
(RefSeq) collapsin response mediator protein 1
  KO
K28086  dihydropyrimidinase-related protein 1
Organism
hsa  Homo sapiens (human)
Network
nt06541  Cytoskeleton in neurons
  Element
N01835  SEMA3-CRMP2/MAPT axon guidance signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1400 (CRMP1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     1400 (CRMP1)
SSDB
Motif
Pfam: Amidohydro_1 Amidohydro_3 Amidohydro_2
Other DBs
NCBI-GeneID: 1400
NCBI-ProteinID: NP_001304
OMIM: 602462
HGNC: 2365
Ensembl: ENSG00000072832
UniProt: Q14194 Q96I11
Structure
LinkDB
Position
4:complement(5820764..5893086)
AA seq 572 aa
MSYQGKKSIPHITSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEA
NGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSF
EKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQ
LYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAI
TIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEE
RMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTI
TAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFPEHLYQ
RVKIRNKVFGLQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFS
LSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
NT seq 1719 nt   +upstreamnt  +downstreamnt
atgtcgtaccagggcaagaagagcatcccgcacatcacgagtgaccgactcctcatcaaa
ggtggacggatcatcaacgatgaccaatccctttatgctgacgtctacctggaggatgga
cttatcaaacaaataggagagaacttaatcgttcctggtggagtgaagaccattgaagcc
aacgggcggatggttattcccggaggtattgatgtcaacacgtacctgcagaagccctcc
caggggatgactgcggctgatgacttcttccaagggaccagggcggcactggtgggcggg
accacgatgatcattgaccatgttgttcctgaacctgggtccagcctactgacctctttc
gagaagtggcacgaagcagctgacaccaaatcctgctgtgattactccctccacgtggac
atcacaagctggtacgatggcgttcgggaggagctggaggtgctggtgcaggacaaaggc
gtcaattccttccaagtctacatggcctataaggatgtctaccaaatgtccgacagccag
ctctatgaagcctttaccttccttaagggcctgggagctgtgatcttggtccatgcagaa
aatggagatttgatagctcaggaacaaaagcggatcctggagatgggcatcacgggtccc
gagggccatgccctgagcagacctgaagagctggaggccgaggcggtgttccgggccatc
accattgcgggccggatcaactgccctgtgtacatcaccaaggtcatgagcaagagtgca
gccgacatcatcgctctggccaggaagaaagggcccctagtttttggagagcccattgcc
gccagcctggggaccgatggcacccattactggagcaagaactgggccaaggctgcggcg
ttcgtgacttcccctcccctgagcccggaccctaccacgcccgactacttgacctcccta
ctggcctgtggggacttgcaggtcacaggcagcggccactgtccctacagcactgcccag
aaggcggtgggcaaggacaactttaccctgatccccgagggtgtcaacgggatagaggag
cggatgacggtcgtctgggacaaggcggtggctactggcaaaatggatgagaaccagttt
gtcgctgtcaccagcaccaatgcagccaagatctttaacctgtacccaaggaaagggcgg
attgccgtgggctcggatgccgacgtggtcatctgggaccccgacaagttgaagaccata
acagccaaaagtcacaagtcggcggtggagtacaacatcttcgagggtatggagtgccac
ggctccccactagtggtcatcagccagggcaagatcgtctttgaagacggaaacatcaac
gtcaacaagggcatgggccgcttcattccgcggaaggcgttcccggagcacctgtaccag
cgcgtcaaaatcaggaataaggtttttggattgcaaggggtttccaggggcatgtatgac
ggtcctgtgtacgaggtaccagctacacccaaatatgcaactcccgctccttcagccaaa
tcttcgccttctaaacaccagcccccacccatcagaaacctccaccagtccaacttcagc
ttatcaggtgcccagatagatgacaacaatcccaggcgcaccggccaccgcatcgtggcg
ccccctggtggccgctccaacatcaccagcctcggttga

KEGG   Homo sapiens (human): 1808
Entry
1808              CDS       T01001                                 
Symbol
DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
Name
(RefSeq) dihydropyrimidinase like 2
  KO
K07528  dihydropyrimidinase-related protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Network
nt06541  Cytoskeleton in neurons
  Element
N01835  SEMA3-CRMP2/MAPT axon guidance signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    1808 (DPYSL2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1808 (DPYSL2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     1808 (DPYSL2)
SSDB
Motif
Pfam: Amidohydro_1 Amidohydro_3
Other DBs
NCBI-GeneID: 1808
NCBI-ProteinID: NP_001377
OMIM: 602463
HGNC: 3014
Ensembl: ENSG00000092964
UniProt: Q16555
Structure
LinkDB
Position
8:26514031..26658175
AA seq 572 aa
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA
HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF
DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ
IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI
TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA
FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE
RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI
SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK
RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS
LSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
NT seq 1719 nt   +upstreamnt  +downstreamnt
atgtcttatcaggggaagaaaaatattccacgcatcacgagcgatcgtcttctgatcaaa
ggaggtaaaattgttaatgatgaccagtcgttctatgcagacatatacatggaagatggg
ttgatcaagcaaataggagaaaatctgattgtgccaggaggagtgaagaccatcgaggcc
cactcccggatggtgatccccggaggaattgacgtccacactcgtttccagatgcctgat
cagggaatgacgtctgctgatgatttcttccaaggaaccaaggcggccctggctggggga
accactatgatcattgaccacgttgttcctgagcctgggacaagcctgctcgctgccttt
gaccagtggagggaatgggccgacagcaagtcctgctgtgactactctctgcatgtggac
atcagtgagtggcataagggcatccaggaggagatggaagcgcttgtgaaggatcacggg
gtaaattccttcctcgtgtacatggctttcaaagatcgcttccagctaacggattgccag
atttatgaagtactgagtgtgatccgggatattggcgccatagcccaagtccacgcagaa
aatggcgacatcattgcagaggagcagcagaggatcctggatctgggcatcacgggcccc
gagggacatgtgctgagccgacctgaggaggtcgaggccgaagccgtgaatcgtgccatc
accatcgccaaccagaccaactgcccgctgtatatcaccaaggtgatgagcaaaagctct
gctgaggtcatcgcccaggcacggaagaagggaactgtggtgtatggcgagcccatcact
gccagcttgggaacggacggctcccattactggagcaagaactgggccaaggctgctgcc
tttgtcacctccccacccttgagccctgatccaaccactccagactttctcaactccttg
ctgtcctgtggagacctccaggtcacgggcagtgcccattgcacgtttaacactgcccag
aaggctgtaggaaaggacaacttcaccctgattccggagggcaccaatggcactgaggag
cggatgtccgtcatctgggacaaggctgtggtcactgggaagatggatgagaaccagttt
gtggctgtgaccagcaccaatgcagccaaagtcttcaacctttacccccggaaaggccgc
attgctgtgggatccgatgccgacctggtcatctgggaccccgacagcgttaaaaccatc
tctgccaagacacacaacagctctctcgagtacaacatctttgaaggcatggagtgccgc
ggctccccactggtggtcatcagccaggggaagattgtcctggaggacggcaccctgcat
gtcaccgaaggctctggacgctacattccccggaagcccttccctgattttgtttacaag
cgtatcaaggcaaggagcaggctggctgagctgagaggggttcctcgtggcctgtatgac
ggacctgtgtgtgaagtgtctgtgacgcccaagacagtcactccagcctcctcggccaag
acgtctcctgccaagcagcaggccccacctgtccggaacctgcaccagtctggattcagt
ttgtctggtgctcagattgatgacaacattccccgccgcaccacccagcgtatcgtggcg
ccccccggtggccgtgccaacatcaccagcctgggctag

KEGG   Homo sapiens (human): 4137
Entry
4137              CDS       T01001                                 
Symbol
MAPT, DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, Tau-PHF6, tau-40
Name
(RefSeq) microtubule associated protein tau
  KO
K04380  microtubule-associated protein tau
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06541  Cytoskeleton in neurons
  Element
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01835  SEMA3-CRMP2/MAPT axon guidance signaling
N01858  EFNB1-MAPT axon guidance signaling
Disease
H00057  Parkinson disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00077  Progressive supranuclear palsy
H00078  Frontotemporal lobar degeneration
Drug target
Bepranemab: D12228
Etalanetug: D12848
Flortaucipir (18F): D11210<JP/US>
Gosuranemab: D11293
Hydromethylthionine (DG03014): D11384 D11427
Posdinemab: D12636
Semorinemab: D11687
Tilavonemab: D11840
Zagotenemab: D11533
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4137 (MAPT)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4137 (MAPT)
   05012 Parkinson disease
    4137 (MAPT)
   05022 Pathways of neurodegeneration - multiple diseases
    4137 (MAPT)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    4137 (MAPT)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4137 (MAPT)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4137 (MAPT)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     4137 (MAPT)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    4137 (MAPT)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     4137 (MAPT)
SSDB
Motif
Pfam: Tubulin-binding Tmemb_cc2
Other DBs
NCBI-GeneID: 4137
NCBI-ProteinID: NP_058519
OMIM: 157140
HGNC: 6893
Ensembl: ENSG00000186868
UniProt: P10636
Structure
LinkDB
Position
17:45894554..46028334
AA seq 758 aa
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
NT seq 2277 nt   +upstreamnt  +downstreamnt
atggctgagccccgccaggagttcgaagtgatggaagatcacgctgggacgtacgggttg
ggggacaggaaagatcaggggggctacaccatgcaccaagaccaagagggtgacacggac
gctggcctgaaagaatctcccctgcagacccccactgaggacggatctgaggaaccgggc
tctgaaacctctgatgctaagagcactccaacagcggaagatgtgacagcacccttagtg
gatgagggagctcccggcaagcaggctgccgcgcagccccacacggagatcccagaagga
accacagctgaagaagcaggcattggagacacccccagcctggaagacgaagctgctggt
cacgtgacccaagagcctgaaagtggtaaggtggtccaggaaggcttcctccgagagcca
ggccccccaggtctgagccaccagctcatgtccggcatgcctggggctcccctcctgcct
gagggccccagagaggccacacgccaaccttcggggacaggacctgaggacacagagggc
ggccgccacgcccctgagctgctcaagcaccagcttctaggagacctgcaccaggagggg
ccgccgctgaagggggcagggggcaaagagaggccggggagcaaggaggaggtggatgaa
gaccgcgacgtcgatgagtcctccccccaagactcccctccctccaaggcctccccagcc
caagatgggcggcctccccagacagccgccagagaagccaccagcatcccaggcttccca
gcggagggtgccatccccctccctgtggatttcctctccaaagtttccacagagatccca
gcctcagagcccgacgggcccagtgtagggcgggccaaagggcaggatgcccccctggag
ttcacgtttcacgtggaaatcacacccaacgtgcagaaggagcaggcgcactcggaggag
catttgggaagggctgcatttccaggggcccctggagaggggccagaggcccggggcccc
tctttgggagaggacacaaaagaggctgaccttccagagccctctgaaaagcagcctgct
gctgctccgcgggggaagcccgtcagccgggtccctcaactcaaagctcgcatggtcagt
aaaagcaaagacgggactggaagcgatgacaaaaaagccaagacatccacacgttcctct
gctaaaaccttgaaaaataggccttgccttagccccaaacaccccactcctggtagctca
gaccctctgatccaaccctccagccctgctgtgtgcccagagccaccttcctctcctaaa
tacgtctcttctgtcacttcccgaactggcagttctggagcaaaggagatgaaactcaag
ggggctgatggtaaaacgaagatcgccacaccgcggggagcagcccctccaggccagaag
ggccaggccaacgccaccaggattccagcaaaaaccccgcccgctccaaagacaccaccc
agctctggtgaacctccaaaatcaggggatcgcagcggctacagcagccccggctcccca
ggcactcccggcagccgctcccgcaccccgtcccttccaaccccacccacccgggagccc
aagaaggtggcagtggtccgtactccacccaagtcgccgtcttccgccaagagccgcctg
cagacagcccccgtgcccatgccagacctgaagaatgtcaagtccaagatcggctccact
gagaacctgaagcaccagccgggaggcgggaaggtgcagataattaataagaagctggat
cttagcaacgtccagtccaagtgtggctcaaaggataatatcaaacacgtcccgggaggc
ggcagtgtgcaaatagtctacaaaccagttgacctgagcaaggtgacctccaagtgtggc
tcattaggcaacatccatcataaaccaggaggtggccaggtggaagtaaaatctgagaag
cttgacttcaaggacagagtccagtcgaagattgggtccctggacaatatcacccacgtc
cctggcggaggaaataaaaagattgaaacccacaagctgaccttccgcgagaacgccaaa
gccaagacagaccacggggcggagatcgtgtacaagtcgccagtggtgtctggggacacg
tctccacggcatctcagcaatgtctcctccaccggcagcatcgacatggtagactcgccc
cagctcgccacgctagctgacgaggtgtctgcctccctggccaagcagggtttgtga

DBGET integrated database retrieval system