Homo sapiens (human): 3479
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Entry
3479 CDS
T01001
Symbol
IGF1, IGF, IGF-I, IGFI, MGF
Name
(RefSeq) insulin like growth factor 1
KO
K05459
insulin-like growth factor 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04114
Oocyte meiosis
hsa04115
p53 signaling pathway
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04510
Focal adhesion
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04730
Long-term depression
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04913
Ovarian steroidogenesis
hsa04914
Progesterone-mediated oocyte maturation
hsa04935
Growth hormone synthesis, secretion and action
hsa04960
Aldosterone-regulated sodium reabsorption
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05205
Proteoglycans in cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05224
Breast cancer
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06324
GHRH-GH-IGF signaling
nt06526
MAPK signaling
nt06530
PI3K signaling
Element
N00133
EWSR1-FLI1 fusion to transcriptional activation
N00135
EWSR1-ERG fusion to transcriptional activation
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00233
IGF-IGF1R-RAS-ERK signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00907
GH-Jak-STAT signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H00015
Malignant pleural mesothelioma
H02040
Insulin-like growth factor I deficiency
Drug target
Masoprocol:
D04862
Toremifene (
DG00735
):
D00967
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3479 (IGF1)
04014 Ras signaling pathway
3479 (IGF1)
04015 Rap1 signaling pathway
3479 (IGF1)
04066 HIF-1 signaling pathway
3479 (IGF1)
04068 FoxO signaling pathway
3479 (IGF1)
04151 PI3K-Akt signaling pathway
3479 (IGF1)
04152 AMPK signaling pathway
3479 (IGF1)
04150 mTOR signaling pathway
3479 (IGF1)
09140 Cellular Processes
09143 Cell growth and death
04114 Oocyte meiosis
3479 (IGF1)
04115 p53 signaling pathway
3479 (IGF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
3479 (IGF1)
04550 Signaling pathways regulating pluripotency of stem cells
3479 (IGF1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
3479 (IGF1)
04914 Progesterone-mediated oocyte maturation
3479 (IGF1)
04935 Growth hormone synthesis, secretion and action
3479 (IGF1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
3479 (IGF1)
09156 Nervous system
04730 Long-term depression
3479 (IGF1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
3479 (IGF1)
09149 Aging
04211 Longevity regulating pathway
3479 (IGF1)
04213 Longevity regulating pathway - multiple species
3479 (IGF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3479 (IGF1)
05202 Transcriptional misregulation in cancer
3479 (IGF1)
05205 Proteoglycans in cancer
3479 (IGF1)
09162 Cancer: specific types
05214 Glioma
3479 (IGF1)
05218 Melanoma
3479 (IGF1)
05215 Prostate cancer
3479 (IGF1)
05224 Breast cancer
3479 (IGF1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3479 (IGF1)
05414 Dilated cardiomyopathy
3479 (IGF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
3479 (IGF1)
01522 Endocrine resistance
3479 (IGF1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
3479 (IGF1)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Growth factors (RTK binding)
3479 (IGF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Insulin
DUF2865
Motif
Other DBs
NCBI-GeneID:
3479
NCBI-ProteinID:
NP_001104755
OMIM:
147440
HGNC:
5464
Ensembl:
ENSG00000017427
Pharos:
P05019
(Tbio)
CPD:
C16131
UniProt:
P05019
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:complement(102395874..102481839)
Genome browser
AA seq
195 aa
AA seq
DB search
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRR
EIGSRNAECRGKKGK
NT seq
588 nt
NT seq
+upstream
nt +downstream
nt
atgggaaaaatcagcagtcttccaacccaattatttaagtgctgcttttgtgatttcttg
aaggtgaagatgcacaccatgtcctcctcgcatctcttctacctggcgctgtgcctgctc
accttcaccagctctgccacggctggaccggagacgctctgcggggctgagctggtggat
gctcttcagttcgtgtgtggagacaggggcttttatttcaacaagcccacagggtatggc
tccagcagtcggagggcgcctcagacaggcatcgtggatgagtgctgcttccggagctgt
gatctaaggaggctggagatgtattgcgcacccctcaagcctgccaagtcagctcgctct
gtccgtgcccagcgccacaccgacatgcccaagacccagaagtatcagcccccatctacc
aacaagaacacgaagtctcagagaaggaaaggttggccaaagacacatccaggaggggaa
cagaaggaggggacagaagcaagtctgcagatcagaggaaagaagaaagagcagaggagg
gagattggaagtagaaatgctgaatgcagaggcaaaaaaggaaaatga
Homo sapiens (human): 3481
Help
Entry
3481 CDS
T01001
Symbol
IGF2, C11orf43, GRDF, IGF-II, PP9974, SRS3
Name
(RefSeq) insulin like growth factor 2
KO
K13769
insulin-like growth factor 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05225
Hepatocellular carcinoma
Network
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06324
GHRH-GH-IGF signaling
nt06526
MAPK signaling
nt06530
PI3K signaling
Element
N00233
IGF-IGF1R-RAS-ERK signaling pathway
N00234
IGF2-IGF1R-PI3K signaling pathway
N00235
IGF2-overexpression to RAS-ERK signaling pathway
N00236
IGF2-overexpression to PI3K signaling pathway
N00237
IGF1R-overexpression to RAS-ERK signaling pathway
N00238
IGF1R-overexpression to PI3K signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H00033
Adrenal carcinoma
H00048
Hepatocellular carcinoma
H00711
Russell-Silver syndrome
H00713
Beckwith-Wiedemann syndrome
Drug target
Dusigitumab:
D10352
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3481 (IGF2)
04014 Ras signaling pathway
3481 (IGF2)
04151 PI3K-Akt signaling pathway
3481 (IGF2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3481 (IGF2)
05205 Proteoglycans in cancer
3481 (IGF2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
3481 (IGF2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
3481 (IGF2)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3481 (IGF2)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Growth factors (RTK binding)
3481 (IGF2)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Growth factors/receptors
3481 (IGF2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IGF2_C
Insulin
Motif
Other DBs
NCBI-GeneID:
3481
NCBI-ProteinID:
NP_000603
OMIM:
147470
HGNC:
5466
Ensembl:
ENSG00000167244
Pharos:
P01344
(Tbio)
CPD:
C16132
UniProt:
P01344
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(2129117..2149566)
Genome browser
AA seq
180 aa
AA seq
DB search
MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVS
RRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWK
QSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK
NT seq
543 nt
NT seq
+upstream
nt +downstream
nt
atgggaatcccaatggggaagtcgatgctggtgcttctcaccttcttggccttcgcctcg
tgctgcattgctgcttaccgccccagtgagaccctgtgcggcggggagctggtggacacc
ctccagttcgtctgtggggaccgcggcttctacttcagcaggcccgcaagccgtgtgagc
cgtcgcagccgtggcatcgttgaggagtgctgtttccgcagctgtgacctggccctcctg
gagacgtactgtgctacccccgccaagtccgagagggacgtgtcgacccctccgaccgtg
cttccggacaacttccccagataccccgtgggcaagttcttccaatatgacacctggaag
cagtccacccagcgcctgcgcaggggcctgcctgccctcctgcgtgcccgccggggtcac
gtgctcgccaaggagctcgaggcgttcagggaggccaaacgtcaccgtcccctgattgct
ctacccacccaagaccccgcccacgggggcgcccccccagagatggccagcaatcggaag
tga
DBGET
integrated database retrieval system