KEGG   ORTHOLOGY: K05411
Entry
K05411                      KO                                     
Symbol
IRF3
Name
interferon regulatory factor 3
Pathway
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04936  Alcoholic liver disease
map05131  Shigellosis
map05133  Pertussis
map05135  Yersinia infection
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05203  Viral carcinogenesis
map05417  Lipid and atherosclerosis
Disease
H02536  Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05411  IRF3; interferon regulatory factor 3
   04621 NOD-like receptor signaling pathway
    K05411  IRF3; interferon regulatory factor 3
   04622 RIG-I-like receptor signaling pathway
    K05411  IRF3; interferon regulatory factor 3
   04623 Cytosolic DNA-sensing pathway
    K05411  IRF3; interferon regulatory factor 3
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05411  IRF3; interferon regulatory factor 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05411  IRF3; interferon regulatory factor 3
   05161 Hepatitis B
    K05411  IRF3; interferon regulatory factor 3
   05160 Hepatitis C
    K05411  IRF3; interferon regulatory factor 3
   05171 Coronavirus disease - COVID-19
    K05411  IRF3; interferon regulatory factor 3
   05164 Influenza A
    K05411  IRF3; interferon regulatory factor 3
   05162 Measles
    K05411  IRF3; interferon regulatory factor 3
   05168 Herpes simplex virus 1 infection
    K05411  IRF3; interferon regulatory factor 3
   05163 Human cytomegalovirus infection
    K05411  IRF3; interferon regulatory factor 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05411  IRF3; interferon regulatory factor 3
   05169 Epstein-Barr virus infection
    K05411  IRF3; interferon regulatory factor 3
   05165 Human papillomavirus infection
    K05411  IRF3; interferon regulatory factor 3
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05411  IRF3; interferon regulatory factor 3
   05135 Yersinia infection
    K05411  IRF3; interferon regulatory factor 3
   05133 Pertussis
    K05411  IRF3; interferon regulatory factor 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05411  IRF3; interferon regulatory factor 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05411  IRF3; interferon regulatory factor 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05411  IRF3; interferon regulatory factor 3
   04131 Membrane trafficking
    K05411  IRF3; interferon regulatory factor 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Helix-turn-helix
   Tryptophan clusters interferon-regulating factors
    K05411  IRF3; interferon regulatory factor 3
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   TRIM-directed selective autophagy
    K05411  IRF3; interferon regulatory factor 3
Genes
HSA: 3661(IRF3)
PTR: 747565(IRF3)
PPS: 100977114(IRF3)
GGO: 101144709(IRF3)
PON: 100441280(IRF3)
NLE: 100603099(IRF3)
MCC: 718970(IRF3)
MCF: 102132745(IRF3)
CSAB: 103235050(IRF3)
CATY: 105595300(IRF3)
PANU: 101013579(IRF3)
TGE: 112612899(IRF3)
RRO: 104667206(IRF3)
RBB: 108535826(IRF3)
TFN: 117091591(IRF3)
PTEH: 111519959(IRF3)
CJC: 100414132(IRF3)
SBQ: 101033122(IRF3)
CSYR: 103249777(IRF3)
MMUR: 105865644(IRF3)
LCAT: 123623813(IRF3)
OGA: 100943304(IRF3)
MMU: 54131(Irf3)
MCAL: 110298322(Irf3)
MPAH: 110332836(Irf3)
RNO: 292892(Irf3)
MCOC: 116102161(Irf3)
CGE: 100765676(Irf3)
MAUA: 101827541(Irf3)
PLEU: 114687156(Irf3)
MORG: 121451666(Irf3)
AAMP: 119802528(Irf3)
NGI: 103743674(Irf3)
HGL: 101722762(Irf3)
CPOC: 100724910(Irf3)
CCAN: 109683903(Irf3)
DORD: 105994272(Irf3)
DSP: 122125825(Irf3)
NCAR: 124967322
OCU: 103346571(IRF3)
OPI: 101528748(IRF3)
TUP: 102489835(IRF3)
CFA: 476412(IRF3)
VVP: 112931284(IRF3)
VLG: 121483963(IRF3)
AML: 100471184(IRF3)
UMR: 103657131(IRF3)
UAH: 113243290(IRF3)
UAR: 123776252(IRF3)
ELK: 111160645
LLV: 125088511
MPUF: 101693423(IRF3)
ORO: 101386524(IRF3)
EJU: 114199531(IRF3)
ZCA: 113936398(IRF3)
MLX: 117998287(IRF3)
FCA: 101095934(IRF3)
PYU: 121018789(IRF3)
PBG: 122493856(IRF3)
PTG: 102956602(IRF3)
PPAD: 109253050(IRF3)
AJU: 106983140(IRF3)
HHV: 120244065(IRF3)
BTA: 516979(IRF3)
BOM: 102279593(IRF3)
BIU: 109572224(IRF3)
BBUB: 102396674(IRF3)
CHX: 102171811(IRF3)
OAS: 780485(IRF3)
ODA: 120872121(IRF3)
CCAD: 122421010(IRF3)
SSC: 396656(IRF3)
CFR: 102506077(IRF3)
CBAI: 105062642(IRF3)
CDK: 105100198(IRF3)
VPC: 102536109(IRF3)
BACU: 103004904(IRF3)
LVE: 103070943(IRF3)
OOR: 101272168(IRF3)
DLE: 111180609(IRF3)
PCAD: 102986279(IRF3)
PSIU: 116744395(IRF3)
ECB: 100055868(IRF3)
EPZ: 103541756(IRF3)
EAI: 106824161(IRF3)
MYB: 102241188(IRF3)
MYD: 102760165(IRF3)
MMYO: 118655420(IRF3)
MLF: 102422872(IRF3)
MNA: 107531880(IRF3)
PKL: 118712200(IRF3)
HAI: 109391076(IRF3)
DRO: 112310089(IRF3)
AJM: 119045996(IRF3)
PDIC: 114511489(IRF3)
PHAS: 123830327(IRF3)
MMF: 118639395(IRF3)
RFQ: 117035039(IRF3)
PALE: 102878862(IRF3)
PGIG: 120615538(IRF3)
PVP: 105301733(IRF3)
RAY: 107498821(IRF3)
MJV: 108400317(IRF3)
TOD: 119249593(IRF3)
SARA: 101542890(IRF3)
LAV: 100667571(IRF3)
TMU: 101348880
DNM: 101415954(IRF3)
MDO: 100030239(IRF3)
GAS: 123256113(IRF3)
SHR: 100933650
PCW: 110219913(IRF3)
OAA: 114814621(IRF3)
ASN: 102368478(IRF3)
AMJ: 102560503(IRF3)
CMY: 114019695(IRF3)
CPIC: 101938664(IRF3)
CABI: 116818009(IRF3)
MRV: 120388286(IRF3)
ACS: 100561376(irf3)
PVT: 110079174(IRF3)
SUND: 121932898(IRF3)
PBI: 103059405(IRF3)
PMUR: 107282419(IRF3)
TSR: 106553402(IRF3)
PGUT: 117664473(IRF3)
VKO: 123030475(IRF3)
PMUA: 114582063(IRF3)
ZVI: 118095336(IRF3)
GJA: 107108113(IRF3)
STOW: 125444651(IRF3)
XLA: 108695903 108697781(irf3.S) 379275(irf3.L)
XTR: 101734275(irf3)
RTEM: 120916504(IRF3) 120916505
BBUF: 121002490(IRF3)
BGAR: 122926675(IRF3)
DRE: 564854(irf3)
PPRM: 120470441(irf3)
MAMB: 125255661(irf3)
IPU: 108273898(irf3)
PHYP: 113527080
SMEO: 124389156(irf3)
TFD: 113653598(irf3)
AMEX: 103032028
EEE: 113590849
TRU: 101071639
LCO: 104935901(irf3)
NCC: 104948891
CGOB: 115024497
ELY: 117247071(irf3)
PLEP: 121958671(irf3)
SLUC: 116061477(irf3)
ECRA: 117937301(irf3)
PFLV: 114547777
GAT: 120819100(irf3)
PPUG: 119212633(irf3)
MSAM: 119915748(irf3)
CUD: 121528801(irf3)
ALAT: 119009595(irf3)
MZE: 101466323
ONL: 100702954
OAU: 116319913(irf3)
OLA: 101158892
OML: 112154159(irf3)
XMA: 102228854
XCO: 114156047
XHE: 116727668
PRET: 103481249
PFOR: 103156846
GAF: 122823590(irf3)
CVG: 107097205
CTUL: 119777604(irf3)
GMU: 124875664(irf3)
NFU: 107387991
KMR: 108237204(irf3)
ALIM: 106517444
NWH: 119423589(irf3)
AOCE: 111584600
CSEM: 103382011
POV: 109642328
SSEN: 122759291(irf3)
HHIP: 117753319(irf3)
HSP: 118100461(irf3)
LCF: 108884442
SDU: 111219805
SLAL: 111658714
XGL: 120794262(irf3)
HCQ: 109523980
BPEC: 110159564
MALB: 109963625
BSPL: 114845285(irf3)
SASA: 100337625(irf-3)
OTW: 112235560(irf3)
OMY: 100750229(irf3)
OGO: 124048534(irf3)
ONE: 115106747
SALP: 111978255
SNH: 120046426(irf3)
ELS: 105026239
SFM: 108925144(irf3)
PKI: 111851276(irf3)
LOC: 107075358(irf3)
PSPA: 121305885
LCM: 102348631(IRF3)
CMK: 103173446(irf3)
RMP: 119160786
 » show all
Reference
PMID:8524823
  Authors
Au WC, Moore PA, Lowther W, Juang YT, Pitha PM
  Title
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
  Journal
Proc Natl Acad Sci U S A 92:11657-61 (1995)
DOI:10.1073/pnas.92.25.11657
  Sequence
[hsa:3661]
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