Homo sapiens (human): 3798
Help
Entry
3798 CDS
T01001
Symbol
KIF5A, ALS25, D12S1889, MY050, NEIMY, NKHC, SPG10
Name
(RefSeq) kinesin family member 5A
KO
K10396
kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:
5.6.1.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04144
Endocytosis
hsa04728
Dopaminergic synapse
hsa04814
Motor proteins
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05132
Salmonella infection
hsa05223
Non-small cell lung cancer
Network
nt06181
Salmonella
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06541
Cytoskeleton in neurons
Element
N00978
Anterograde axonal transport
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N01017
Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055
Mutation-caused aberrant SNCA to anterograde axonal transport
N01202
Oligomeric conformation PrPc to anterograde axonal transport
N01297
Arl8-regulated microtubule plus-end directed transport
N01298
Salmonella SifA to microtubule plus-end directed transport
N01299
Salmonella PipB2 to microtubule plus-end directed transport
N01859
Anterograde axonal/dendrite transport, Kinesin-1
Disease
H00058
Amyotrophic lateral sclerosis (ALS)
H00266
Hereditary spastic paraplegia
H02819
Neonatal intractable myoclonus
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
3798 (KIF5A)
09142 Cell motility
04814 Motor proteins
3798 (KIF5A)
09150 Organismal Systems
09156 Nervous system
04728 Dopaminergic synapse
3798 (KIF5A)
09160 Human Diseases
09162 Cancer: specific types
05223 Non-small cell lung cancer
3798 (KIF5A)
09171 Infectious disease: bacterial
05132 Salmonella infection
3798 (KIF5A)
09164 Neurodegenerative disease
05010 Alzheimer disease
3798 (KIF5A)
05012 Parkinson disease
3798 (KIF5A)
05014 Amyotrophic lateral sclerosis
3798 (KIF5A)
05016 Huntington disease
3798 (KIF5A)
05020 Prion disease
3798 (KIF5A)
05022 Pathways of neurodegeneration - multiple diseases
3798 (KIF5A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
3798 (KIF5A)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
3798 (KIF5A)
04147 Exosome [BR:
hsa04147
]
3798 (KIF5A)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.1 Enzymes altering polypeptide conformation or assembly
5.6.1.3 plus-end-directed kinesin ATPase
3798 (KIF5A)
Membrane trafficking [BR:
hsa04131
]
Others
Actin-binding proteins
Others
3798 (KIF5A)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulin-binding proteins
Kinesins
3798 (KIF5A)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3798 (KIF5A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Kinesin
Microtub_bd
ATG16
Motif
Other DBs
NCBI-GeneID:
3798
NCBI-ProteinID:
NP_004975
OMIM:
602821
HGNC:
6323
Ensembl:
ENSG00000155980
UniProt:
Q12840
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:57550044..57586633
Genome browser
AA seq
1032 aa
AA seq
DB search
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQE
QVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEI
LDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTM
FICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETI
AKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEE
IRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA
KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVS
GHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKS
VVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEES
YDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDE
INEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL
KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQL
TKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRI
KEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQ
ATPSSTSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQA
KLFPLHQETAAS
NT seq
3099 nt
NT seq
+upstream
nt +downstream
nt
atggcggagaccaacaacgaatgtagcatcaaggtgctctgccgattccggcccctgaac
caggctgagattctgcggggagacaagttcatccccattttccaaggggacgacagcgtc
gttattggggggaagccatatgtttttgaccgtgtattccccccaaacacgactcaagag
caagtttatcatgcatgtgccatgcagattgtcaaagatgtccttgctggctacaatggc
accatttttgcttatggacagacatcctcagggaaaacacataccatggagggaaagctg
cacgaccctcagctgatgggaatcattcctcgaattgcccgagacatcttcaaccacatc
tactccatggatgagaaccttgagttccacatcaaggtttcttactttgaaatttacctg
gacaaaattcgtgaccttctggatgtgaccaagacaaatctgtccgtgcacgaggacaag
aaccgggtgccatttgtcaagggttgtactgaacgctttgtgtccagcccggaggagatt
ctggatgtgattgatgaagggaaatcaaatcgtcatgtggctgtcaccaacatgaatgaa
cacagctctcggagccacagcatcttcctcatcaacatcaagcaggagaacatggaaacg
gagcagaagctcagtgggaagctgtatctggtggacctggcagggagtgagaaggtcagc
aagactggagcagagggagccgtgctggacgaggcaaagaatatcaacaagtcactgtca
gctctgggcaatgtgatctccgcactggctgagggcactaaaagctatgttccatatcgt
gacagcaaaatgacaaggattctccaggactctctcgggggaaactgccggacgactatg
ttcatctgttgctcaccatccagttataatgatgcagagaccaagtccaccctgatgttt
gggcagcgggcaaagaccattaagaacactgcctcagtaaatttggagttgactgctgag
cagtggaagaagaaatatgagaaggagaaggagaagacaaaggcccagaaggagacgatt
gcgaagctggaggctgagctgagccggtggcgcaatggagagaatgtgcctgagacagag
cgcctggctggggaggaggcagccctgggagccgagctctgtgaggagacccctgtgaat
gacaactcatccatcgtggtgcgcatcgcgcccgaggagcggcagaaatacgaggaggag
atccgccgtctctataagcagcttgacgacaaggatgatgaaatcaaccaacaaagccaa
ctcatagagaagctcaagcagcaaatgctggaccaggaagagctgctggtgtccacccga
ggagacaacgagaaggtccagcgggagctgagccacctgcaatcagagaacgatgccgct
aaggatgaggtgaaggaagtgctgcaggccctggaggagctggctgtgaactatgaccag
aagtcccaggaggtggaggagaagagccagcagaaccagcttctggtggatgagctgtct
cagaaggtggccaccatgctgtccctggagtctgagttgcagcggctacaggaggtcagt
ggacaccagcgaaaacgaattgctgaggtgctgaacgggctgatgaaggatctgagcgag
ttcagtgtcattgtgggcaacggggagattaagctgccagtggagatcagtggggccatc
gaggaggagttcactgtggcccgactctacatcagcaaaatcaaatcagaagtcaagtct
gtggtcaagcggtgccggcagctggagaacctccaggtggagtgtcaccgcaagatggaa
gtgaccgggcgggagctctcatcctgccagctcctcatctctcagcatgaggccaagatc
cgctcgcttacggaatacatgcagagcgtggagctaaagaagcggcacctggaagagtcc
tatgactccttgagcgatgagctggccaagctccaggcccaggaaactgtgcatgaagtg
gccctgaaggacaaggagcctgacactcaggatgcagatgaagtgaagaaggctctggag
ctgcagatggagagtcaccgggaggcccatcaccggcagctggcccggctccgggacgag
atcaacgagaagcagaagaccattgatgagctcaaagacctaaatcagaagctccagtta
gagctagagaagcttcaggctgactacgagaagctgaagagcgaagaacacgagaagagc
accaagctgcaggagctgacatttctgtacgagcgacatgagcagtccaagcaggacctc
aagggtctggaggagacagttgcccgggaactccagaccctccacaaccttcgcaagctg
ttcgttcaagacgtcacgactcgagtcaagaaaagtgcagaaatggagcccgaagacagt
ggggggattcactcccaaaagcagaagatttcctttcttgagaacaacctggaacagctt
acaaaggttcacaaacagctggtacgtgacaatgcagatctgcgttgtgagcttcctaaa
ttggaaaaacgacttagggctacggctgagagagttaaggccctggagggtgcactgaag
gaggccaaggagggcgccatgaaggacaagcgccggtaccagcaggaggtggaccgcatc
aaggaggccgttcgctacaagagctcgggcaaacggggccattctgcccagattgccaaa
cccgtccggcctggccactacccagcatcctcacccaccaacccctatggcacccggagc
cctgagtgcatcagttacaccaacagcctcttccagaactaccagaatctctacctgcag
gccacacccagctccacctcagatatgtactttgcaaactcctgtaccagcagtggagcc
acatcttctggcggccccttggcttcctaccagaaggccaacatggacaatggaaatgcc
acagatatcaatgacaataggagtgacctgccgtgtggctatgaggctgaggaccaggcc
aagcttttccctctccaccaagagacagcagccagctaa
Homo sapiens (human): 3799
Help
Entry
3799 CDS
T01001
Symbol
KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC
Name
(RefSeq) kinesin family member 5B
KO
K10396
kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:
5.6.1.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04144
Endocytosis
hsa04728
Dopaminergic synapse
hsa04814
Motor proteins
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05132
Salmonella infection
hsa05223
Non-small cell lung cancer
Network
nt06181
Salmonella
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06541
Cytoskeleton in neurons
Element
N00978
Anterograde axonal transport
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N01017
Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055
Mutation-caused aberrant SNCA to anterograde axonal transport
N01202
Oligomeric conformation PrPc to anterograde axonal transport
N01297
Arl8-regulated microtubule plus-end directed transport
N01298
Salmonella SifA to microtubule plus-end directed transport
N01299
Salmonella PipB2 to microtubule plus-end directed transport
N01859
Anterograde axonal/dendrite transport, Kinesin-1
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
3799 (KIF5B)
09142 Cell motility
04814 Motor proteins
3799 (KIF5B)
09150 Organismal Systems
09156 Nervous system
04728 Dopaminergic synapse
3799 (KIF5B)
09160 Human Diseases
09162 Cancer: specific types
05223 Non-small cell lung cancer
3799 (KIF5B)
09171 Infectious disease: bacterial
05132 Salmonella infection
3799 (KIF5B)
09164 Neurodegenerative disease
05010 Alzheimer disease
3799 (KIF5B)
05012 Parkinson disease
3799 (KIF5B)
05014 Amyotrophic lateral sclerosis
3799 (KIF5B)
05016 Huntington disease
3799 (KIF5B)
05020 Prion disease
3799 (KIF5B)
05022 Pathways of neurodegeneration - multiple diseases
3799 (KIF5B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
3799 (KIF5B)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
3799 (KIF5B)
04147 Exosome [BR:
hsa04147
]
3799 (KIF5B)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.1 Enzymes altering polypeptide conformation or assembly
5.6.1.3 plus-end-directed kinesin ATPase
3799 (KIF5B)
Membrane trafficking [BR:
hsa04131
]
Others
Actin-binding proteins
Others
3799 (KIF5B)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulin-binding proteins
Kinesins
3799 (KIF5B)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3799 (KIF5B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Kinesin
Microtub_bd
DUF7310
Motif
Other DBs
NCBI-GeneID:
3799
NCBI-ProteinID:
NP_004512
OMIM:
602809
HGNC:
6324
Ensembl:
ENSG00000170759
UniProt:
P33176
Q6P164
V9HW29
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:complement(32009015..32056425)
Genome browser
AA seq
963 aa
AA seq
DB search
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ
VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY
SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK
TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE
NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL
EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ
DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD
RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG
KQV
NT seq
2892 nt
NT seq
+upstream
nt +downstream
nt
atggcggacctggccgagtgcaacatcaaagtgatgtgtcgcttcagacctctcaacgag
tctgaagtgaaccgcggcgacaagtacatcgccaagtttcagggagaagacacggtcgtg
atcgcgtccaagccttatgcatttgatcgggtgttccagtcaagcacatctcaagagcaa
gtgtataatgactgtgcaaagaagattgttaaagatgtacttgaaggatataatggaaca
atatttgcatatggacaaacatcctctgggaagacacacacaatggagggtaaacttcat
gatccagaaggcatgggaattattccaagaatagtgcaagatatttttaattatatttac
tccatggatgaaaatttggaatttcatattaaggtttcatattttgaaatatatttggat
aagataagggacctgttagatgtttcaaagaccaacctttcagttcatgaagacaaaaac
cgagttccctatgtaaaggggtgcacagagcgttttgtatgtagtccagatgaagttatg
gataccatagatgaaggaaaatccaacagacatgtagcagttacaaatatgaatgaacat
agctctaggagtcacagtatatttcttattaatgtcaaacaagagaacacacaaacggaa
caaaagctgagtggaaaactttatctggttgatttagctggtagtgaaaaggttagtaaa
actggagctgaaggtgctgtgctggatgaagctaaaaacatcaacaagtcactttctgct
cttggaaatgttatttctgctttggctgagggtagtacatatgttccatatcgagatagt
aaaatgacaagaatccttcaagattcattaggtggcaactgtagaaccactattgtaatt
tgctgctctccatcatcatacaatgagtctgaaacaaaatctacactcttatttggccaa
agggccaaaacaattaagaacacagtttgtgtcaatgtggagttaactgcagaacagtgg
aaaaagaagtatgaaaaagaaaaagaaaaaaataagatcctgcggaacactattcagtgg
cttgaaaatgagctcaacagatggcgtaatggggagacggtgcctattgatgaacagttt
gacaaagagaaagccaacttggaagctttcacagtggataaagatattactcttaccaat
gataaaccagcaaccgcaattggagttataggaaattttactgatgctgaaagaagaaag
tgtgaagaagaaattgctaaattatacaaacagcttgatgacaaggatgaagaaattaac
cagcaaagtcaactggtagagaaactgaagacgcaaatgttggatcaggaggagcttttg
gcatctaccagaagggatcaagacaatatgcaagctgagctgaatcgccttcaagcagaa
aatgatgcctctaaagaagaagtgaaagaagttttacaggccctagaagaacttgctgtc
aattatgatcagaagtctcaggaagttgaagacaaaactaaggaatatgaattgcttagt
gatgaattgaatcagaaatcggcaactttagcgagtatagatgctgagcttcagaaactt
aaggaaatgaccaaccaccagaaaaaacgagcagctgagatgatggcatctttactaaaa
gaccttgcagaaataggaattgctgtgggaaataatgatgtaaagcagcctgagggaact
ggcatgatagatgaagagttcactgttgcaagactctacattagcaaaatgaagtcagaa
gtaaaaaccatggtgaaacgttgcaagcagttagaaagcacacaaactgagagcaacaaa
aaaatggaagaaaatgaaaaggagttagcagcatgtcagcttcgtatctctcaacatgaa
gccaaaatcaagtcattgactgaataccttcaaaatgtggaacaaaagaaaagacagttg
gaggaatctgtcgatgccctcagtgaagaactagtccagcttcgagcacaagagaaagtc
catgaaatggaaaaggagcacttaaataaggttcagactgcaaatgaagttaagcaagct
gttgaacagcagatccagagccatagagaaactcatcaaaaacagatcagtagtttgaga
gatgaagtagaagcaaaagcaaaacttattactgatcttcaagaccaaaaccagaaaatg
atgttagagcaggaacgtctaagagtagaacatgagaagttgaaagccacagatcaggaa
aagagcagaaaactacatgaacttacggttatgcaagatagacgagaacaagcaagacaa
gacttgaagggtttggaagagacagtggcaaaagaacttcagactttacacaacctgcgc
aaactctttgttcaggacctggctacaagagttaaaaagagtgctgagattgattctgat
gacaccggaggcagcgctgctcagaagcaaaaaatctcctttcttgaaaataatcttgaa
cagctcactaaagtgcacaaacagttggtacgtgataatgcagatctccgctgtgaactt
cctaagttggaaaagcgacttcgagctacagctgagagagtgaaagctttggaatcagca
ctgaaagaagctaaagaaaatgcatctcgtgatcgcaaacgctatcagcaagaagtagat
cgcataaaggaagcagtcaggtcaaagaatatggccagaagagggcattctgcacagatt
gctaaacctattcgtcccgggcaacatccagcagcttctccaactcacccaagtgcaatt
cgtggaggaggtgcatttgttcagaacagccagccagtggcagtgcgaggtggaggaggc
aaacaagtgtaa
Homo sapiens (human): 3800
Help
Entry
3800 CDS
T01001
Symbol
KIF5C, CDCBM2, KINN, NKHC, NKHC-2, NKHC2
Name
(RefSeq) kinesin family member 5C
KO
K10396
kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:
5.6.1.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04144
Endocytosis
hsa04728
Dopaminergic synapse
hsa04814
Motor proteins
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05132
Salmonella infection
hsa05223
Non-small cell lung cancer
Network
nt06181
Salmonella
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06541
Cytoskeleton in neurons
Element
N00978
Anterograde axonal transport
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N01017
Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01055
Mutation-caused aberrant SNCA to anterograde axonal transport
N01202
Oligomeric conformation PrPc to anterograde axonal transport
N01297
Arl8-regulated microtubule plus-end directed transport
N01298
Salmonella SifA to microtubule plus-end directed transport
N01299
Salmonella PipB2 to microtubule plus-end directed transport
N01859
Anterograde axonal/dendrite transport, Kinesin-1
Disease
H01881
Complex cortical dysplasia with other brain malformations
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
3800 (KIF5C)
09142 Cell motility
04814 Motor proteins
3800 (KIF5C)
09150 Organismal Systems
09156 Nervous system
04728 Dopaminergic synapse
3800 (KIF5C)
09160 Human Diseases
09162 Cancer: specific types
05223 Non-small cell lung cancer
3800 (KIF5C)
09171 Infectious disease: bacterial
05132 Salmonella infection
3800 (KIF5C)
09164 Neurodegenerative disease
05010 Alzheimer disease
3800 (KIF5C)
05012 Parkinson disease
3800 (KIF5C)
05014 Amyotrophic lateral sclerosis
3800 (KIF5C)
05016 Huntington disease
3800 (KIF5C)
05020 Prion disease
3800 (KIF5C)
05022 Pathways of neurodegeneration - multiple diseases
3800 (KIF5C)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
3800 (KIF5C)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
3800 (KIF5C)
04147 Exosome [BR:
hsa04147
]
3800 (KIF5C)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.1 Enzymes altering polypeptide conformation or assembly
5.6.1.3 plus-end-directed kinesin ATPase
3800 (KIF5C)
Membrane trafficking [BR:
hsa04131
]
Others
Actin-binding proteins
Others
3800 (KIF5C)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulin-binding proteins
Kinesins
3800 (KIF5C)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3800 (KIF5C)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Kinesin
Microtub_bd
Cnn_1N
Motif
Other DBs
NCBI-GeneID:
3800
NCBI-ProteinID:
NP_004513
OMIM:
604593
HGNC:
6325
Ensembl:
ENSG00000168280
UniProt:
O60282
Q59GB8
LinkDB
All DBs
Position
2:148875227..149026759
Genome browser
AA seq
957 aa
AA seq
DB search
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQE
QVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEV
MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTI
VICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVI
QHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE
ISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAA
KDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELS
NHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKS
LVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEES
QDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSR
LRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQA
REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENN
LEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQE
VDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK
NT seq
2874 nt
NT seq
+upstream
nt +downstream
nt
atggcggatccagccgaatgcagcatcaaagtgatgtgccggttccggcccctcaacgaa
gcggagatcctccgcggggacaaattcatccccaaatttaaaggcgatgagaccgtggtg
atcgggcaagggaagccatatgtcttcgacagagtgctacctcccaacacgacccaagag
caggtttacaatgcatgtgcgaagcaaattgtcaaagatgtccttgaaggttataacggg
acgatttttgcgtatgggcagacttcatcaggaaaaacccacaccatggaggggaagctg
catgacccccagctcatggggatcatcccacgaattgcccatgatatctttgaccatatc
tactccatggatgagaacctggagtttcacataaaggtttcctattttgagatctacttg
gacaaaataagggacttacttgatgtatccaagaccaacttggctgttcatgaagataaa
aacagagtcccgtatgtaaaggggtgcactgagcggtttgtgtcgagccctgaggaagtc
atggatgtaatagatgaaggcaaagcaaaccgacacgtggctgtgacaaacatgaatgaa
cacagctctagaagtcacagtatcttcctgataaatattaaacaagagaatgtagagact
gaaaaaaaactcagtgggaaactttatttggttgatttggctgggagcgaaaaggtcagc
aaaactggtgccgagggagctgttcttgacgaagctaaaaatatcaataagtctttgtct
gctcttggaaatgtgatctctgctttggcagaagggacaaaaacacatgtgccataccgg
gacagcaagatgactcggattcttcaggactctttgggtgggaactgcagaaccaccatc
gtcatttgctgttctccttctgtcttcaatgaggctgagaccaagtccacactgatgttc
ggacagagagctaagaccatcaagaatacagtctctgtgaacctagaactgacagcagaa
gaatggaagaagaaatatgaaaaagagaaagagaaaaacaagactttgaagaatgttatc
cagcatctggagatggagctaaacaggtggaggaatggagaagctgtgcctgaggatgaa
cagatcagtgccaaggaccagaagaacctggagccttgtgataacacccccatcatagac
aatattgctcctgttgttgctggcatctctacagaggagaaagagaagtacgatgaggag
atctccagtctctacagacaactggatgacaaggatgatgaaattaaccagcagagccag
ctggctgaaaagctgaagcaacagatgttggatcaggatgagcttttagcttccacaaga
agagactatgagaagatacaggaggagctgacacgtctccagattgaaaatgaggcagcc
aaggatgaggtgaaagaagttctccaggccctggaggagctggctgtcaattatgaccag
aaatcacaggaagtggaggataagacccgggccaatgagcagctgacagacgagctggcc
cagaaaacgactacattgacaaccacacagagagagctgagccagctacaagagcttagc
aaccaccagaagaaaagggcaactgagatcctgaatttgctgttgaaagatctgggggag
ataggtggaattattggcaccaatgatgtgaaaactttggcagatgtgaatggagtcatt
gaggaggagtttaccatggcccgcctgtacatcagcaagatgaagtcagaggtcaagtcc
ctggtgaaccgcagcaaacagctcgagagcgcccagatggactccaacaggaagatgaat
gccagcgagcgggagctggcagcctgccagctgctcatctcccagcacgaagccaagatc
aagtctctgacagactacatgcagaacatggaacagaagaggaggcagctagaagagtcc
caggactcgctcagcgaagagctggcaaagctccgagcccaggaaaaaatgcacgaagtc
agcttccaggataaggagaaggaacatctgacgcggttgcaggatgctgaagaaatgaag
aaggcgctggagcagcagatggagagccaccgggaagctcaccagaagcagctgtccaga
ctccgagacgaaattgaggagaagcagaaaatcattgatgagattcgggatttgaatcag
aaactgcaactggaacaggagaagcttagttctgattataacaagctgaaaatagaggac
caagagagagaaatgaagctggaaaagctcttattgctcaacgataaaagggaacaagcc
agagaagacctcaaagggctggaggagacagtgtctagagaattgcagacactgcacaac
cttcggaaactctttgtccaggatctgaccacccgagttaaaaaaagtgtggagttggac
aacgatgatggagggggcagtgctgcccagaagcagaaaatttccttcttggagaataac
ctggagcagctcaccaaagttcacaagcagctggtccgggacaacgcagacctgcgctgt
gaactgcccaagctggagaagcggctgcgtgccacggcggagcgcgtcaaggctctggag
agcgcgctgaaggaggccaaggagaacgccatgcgggaccgtaagcgctaccagcaggag
gtggatcgtatcaaggaggccgtgcgggccaagaacatggccagaagggcccattcagcc
cagatcgccaagcccatccgccccggacactacccggcctcatctccaacggccgtccat
gccattcgagggggaggaggcagctcttcaaattccactcactaccagaaataa
Homo sapiens (human): 5979
Help
Entry
5979 CDS
T01001
Symbol
RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
Name
(RefSeq) ret proto-oncogene
KO
K05126
proto-oncogene tyrosine-protein kinase Ret [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04020
Calcium signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa05200
Pathways in cancer
hsa05216
Thyroid cancer
hsa05223
Non-small cell lung cancer
hsa05230
Central carbon metabolism in cancer
Network
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06266
Non-small cell lung cancer
nt06274
Thyroid cancer
nt06526
MAPK signaling
nt06528
Calcium signaling
Element
N00008
RET fusion kinase to RAS-ERK signaling pathway
N01064
Mutation-activated RET to RAS-ERK signaling pathway
N01065
Mutation-activated RET to PI3K signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01641
RTK-PLCG-ITPR signaling pathway
Disease
H00014
Non-small cell lung cancer
H00032
Thyroid cancer
H00247
Multiple endocrine neoplasia syndrome
H00910
Hirschsprung disease
H01510
Malignant paraganglioma
H01592
Medullary thyroid cancer
Drug target
Enbezotinib:
D12559
Lenvatinib (
DG01362
):
D09919
D09920
<JP/US>
Motesanib (
DG01262
):
D06678
D08947
Pralsetinib (
DG03223
):
D11712
<US>
D12354
Regorafenib (
DG00720
):
D10137
<JP/US>
D10138
Selpercatinib:
D11713
<JP/US>
Sorafenib (
DG00713
):
D06272
<JP/US>
D08524
Sunitinib (
DG00712
):
D06402
<JP/US>
D08552
Vandetanib:
D06407
<JP/US>
Zeteletinib (
DG03221
):
D12330
D12331
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5979 (RET)
04020 Calcium signaling pathway
5979 (RET)
04151 PI3K-Akt signaling pathway
5979 (RET)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5979 (RET)
05230 Central carbon metabolism in cancer
5979 (RET)
09162 Cancer: specific types
05216 Thyroid cancer
5979 (RET)
05223 Non-small cell lung cancer
5979 (RET)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5979 (RET)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
5979 (RET)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
RET family
5979 (RET)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
RET_CLD1
RET_CLD3
RET_CLD4
Pkinase
RET_CRD
Cadherin
RIO1
Pkinase_fungal
Haspin_kinase
ABC1
Motif
Other DBs
NCBI-GeneID:
5979
NCBI-ProteinID:
NP_066124
OMIM:
164761
HGNC:
9967
Ensembl:
ENSG00000165731
UniProt:
P07949
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:43077069..43130351
Genome browser
AA seq
1114 aa
AA seq
DB search
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP
EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT
VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV
AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA
QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE
LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY
HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH
PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY
EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA
STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRA
DGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
NT seq
3345 nt
NT seq
+upstream
nt +downstream
nt
atggcgaaggcgacgtccggtgccgcggggctgcgtctgctgttgctgctgctgctgccg
ctgctaggcaaagtggcattgggcctctacttctcgagggatgcttactgggagaagctg
tatgtggaccaggcagccggcacgcccttgctgtacgtccatgccctgcgggacgcccct
gaggaggtgcccagcttccgcctgggccagcatctctacggcacgtaccgcacacggctg
catgagaacaactggatctgcatccaggaggacaccggcctcctctaccttaaccggagc
ctggaccatagctcctgggagaagctcagtgtccgcaaccgcggctttcccctgctcacc
gtctacctcaaggtcttcctgtcacccacatcccttcgtgagggcgagtgccagtggcca
ggctgtgcccgcgtatacttctccttcttcaacacctcctttccagcctgcagctccctc
aagccccgggagctctgcttcccagagacaaggccctccttccgcattcgggagaaccga
cccccaggcaccttccaccagttccgcctgctgcctgtgcagttcttgtgccccaacatc
agcgtggcctacaggctcctggagggtgagggtctgcccttccgctgcgccccggacagc
ctggaggtgagcacgcgctgggccctggaccgcgagcagcgggagaagtacgagctggtg
gccgtgtgcaccgtgcacgccggcgcgcgcgaggaggtggtgatggtgcccttcccggtg
accgtgtacgacgaggacgactcggcgcccaccttccccgcgggcgtcgacaccgccagc
gccgtggtggagttcaagcggaaggaggacaccgtggtggccacgctgcgtgtcttcgat
gcagacgtggtacctgcatcaggggagctggtgaggcggtacacaagcacgctgctcccc
ggggacacctgggcccagcagaccttccgggtggaacactggcccaacgagacctcggtc
caggccaacggcagcttcgtgcgggcgaccgtacatgactataggctggttctcaaccgg
aacctctccatctcggagaaccgcaccatgcagctggcggtgctggtcaatgactcagac
ttccagggcccaggagcgggcgtcctcttgctccacttcaacgtgtcggtgctgccggtc
agcctgcacctgcccagtacctactccctctccgtgagcaggagggctcgccgatttgcc
cagatcgggaaagtctgtgtggaaaactgccaggcattcagtggcatcaacgtccagtac
aagctgcattcctctggtgccaactgcagcacgctaggggtggtcacctcagccgaggac
acctcggggatcctgtttgtgaatgacaccaaggccctgcggcggcccaagtgtgccgaa
cttcactacatggtggtggccaccgaccagcagacctctaggcaggcccaggcccagctg
cttgtaacagtggaggggtcatatgtggccgaggaggcgggctgccccctgtcctgtgca
gtcagcaagagacggctggagtgtgaggagtgtggcggcctgggctccccaacaggcagg
tgtgagtggaggcaaggagatggcaaagggatcaccaggaacttctccacctgctctccc
agcaccaagacctgccccgacggccactgcgatgttgtggagacccaagacatcaacatt
tgccctcaggactgcctccggggcagcattgttgggggacacgagcctggggagccccgg
gggattaaagctggctatggcacctgcaactgcttccctgaggaggagaagtgcttctgc
gagcccgaagacatccaggatccactgtgcgacgagctgtgccgcacggtgatcgcagcc
gctgtcctcttctccttcatcgtctcggtgctgctgtctgccttctgcatccactgctac
cacaagtttgcccacaagccacccatctcctcagctgagatgaccttccggaggcccgcc
caggccttcccggtcagctactcctcttccggtgcccgccggccctcgctggactccatg
gagaaccaggtctccgtggatgccttcaagatcctggaggatccaaagtgggaattccct
cggaagaacttggttcttggaaaaactctaggagaaggcgaatttggaaaagtggtcaag
gcaacggccttccatctgaaaggcagagcagggtacaccacggtggccgtgaagatgctg
aaagagaacgcctccccgagtgagctgcgagacctgctgtcagagttcaacgtcctgaag
caggtcaaccacccacatgtcatcaaattgtatggggcctgcagccaggatggcccgctc
ctcctcatcgtggagtacgccaaatacggctccctgcggggcttcctccgcgagagccgc
aaagtggggcctggctacctgggcagtggaggcagccgcaactccagctccctggaccac
ccggatgagcgggccctcaccatgggcgacctcatctcatttgcctggcagatctcacag
gggatgcagtatctggccgagatgaagctcgttcatcgggacttggcagccagaaacatc
ctggtagctgaggggcggaagatgaagatttcggatttcggcttgtcccgagatgtttat
gaagaggattcctacgtgaagaggagccagggtcggattccagttaaatggatggcaatt
gaatccctttttgatcatatctacaccacgcaaagtgatgtatggtcttttggtgtcctg
ctgtgggagatcgtgaccctagggggaaacccctatcctgggattcctcctgagcggctc
ttcaaccttctgaagaccggccaccggatggagaggccagacaactgcagcgaggagatg
taccgcctgatgctgcaatgctggaagcaggagccggacaaaaggccggtgtttgcggac
atcagcaaagacctggagaagatgatggttaagaggagagactacttggaccttgcggcg
tccactccatctgactccctgatttatgacgacggcctctcagaggaggagacaccgctg
gtggactgtaataatgcccccctccctcgagccctcccttccacatggattgaaaacaaa
ctctatggcatgtcagacccgaactggcctggagagagtcctgtaccactcacgagagct
gatggcactaacactgggtttccaagatatccaaatgatagtgtatatgctaactggatg
ctttcaccctcagcggcaaaattaatggacacgtttgatagttaa
DBGET
integrated database retrieval system