KEGG   Homo sapiens (human): 54106
Entry
54106             CDS       T01001                                 
Symbol
TLR9, CD289
Name
(RefSeq) toll like receptor 9
  KO
K10161  toll-like receptor 9
Organism
hsa  Homo sapiens (human)
Pathway
hsa04620  Toll-like receptor signaling pathway
hsa05132  Salmonella infection
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05152  Tuberculosis
hsa05162  Measles
hsa05168  Herpes simplex virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06169  Measles virus (MV)
nt06517  TLR signaling
  Element
N00690  TLR7/9-IRF7 signaling pathway
N01543  TLR7/8/9-IRF5 signaling pathway
Drug target
Agatolimod (DG01428): D08841 D08842
Cobitolimod (DG03213): D12275 D12276
Nelitolimod (DG03303): D12855 D12856
Tilsotolimod (DG03024): D11504 D11505
Vidutolimod: D12936
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    54106 (TLR9)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    54106 (TLR9)
  09172 Infectious disease: viral
   05162 Measles
    54106 (TLR9)
   05168 Herpes simplex virus 1 infection
    54106 (TLR9)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    54106 (TLR9)
   05152 Tuberculosis
    54106 (TLR9)
  09174 Infectious disease: parasitic
   05144 Malaria
    54106 (TLR9)
   05142 Chagas disease
    54106 (TLR9)
   05143 African trypanosomiasis
    54106 (TLR9)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    54106 (TLR9)
   04090 CD molecules [BR:hsa04090]
    54106 (TLR9)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   54106 (TLR9)
CD molecules [BR:hsa04090]
 Proteins
  54106 (TLR9)
SSDB
Motif
Pfam: LRR_8 LRR_4 LRR_12 LRR_14 LRR_6 LRR_Zer-1 TIR FNIP TIR_2
Other DBs
NCBI-GeneID: 54106
NCBI-ProteinID: NP_059138
OMIM: 605474
HGNC: 15633
Ensembl: ENSG00000239732
UniProt: Q9NR96
Structure
LinkDB
Position
3:complement(52221080..52225645)
AA seq 1032 aa
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
YNRNFCQGPTAE
NT seq 3099 nt   +upstreamnt  +downstreamnt
atgggtttctgccgcagcgccctgcacccgctgtctctcctggtgcaggccatcatgctg
gccatgaccctggccctgggtaccttgcctgccttcctaccctgtgagctccagccccac
ggcctggtgaactgcaactggctgttcctgaagtctgtgccccacttctccatggcagca
ccccgtggcaatgtcaccagcctttccttgtcctccaaccgcatccaccacctccatgat
tctgactttgcccacctgcccagcctgcggcatctcaacctcaagtggaactgcccgccg
gttggcctcagccccatgcacttcccctgccacatgaccatcgagcccagcaccttcttg
gctgtgcccaccctggaagagctaaacctgagctacaacaacatcatgactgtgcctgcg
ctgcccaaatccctcatatccctgtccctcagccataccaacatcctgatgctagactct
gccagcctcgccggcctgcatgccctgcgcttcctattcatggacggcaactgttattac
aagaacccctgcaggcaggcactggaggtggccccgggtgccctccttggcctgggcaac
ctcacccacctgtcactcaagtacaacaacctcactgtggtgccccgcaacctgccttcc
agcctggagtatctgctgttgtcctacaaccgcatcgtcaaactggcgcctgaggacctg
gccaatctgaccgccctgcgtgtgctcgatgtgggcggaaattgccgccgctgcgaccac
gctcccaacccctgcatggagtgccctcgtcacttcccccagctacatcccgataccttc
agccacctgagccgtcttgaaggcctggtgttgaaggacagttctctctcctggctgaat
gccagttggttccgtgggctgggaaacctccgagtgctggacctgagtgagaacttcctc
tacaaatgcatcactaaaaccaaggccttccagggcctaacacagctgcgcaagcttaac
ctgtccttcaattaccaaaagagggtgtcctttgcccacctgtctctggccccttccttc
gggagcctggtcgccctgaaggagctggacatgcacggcatcttcttccgctcactcgat
gagaccacgctccggccactggcccgcctgcccatgctccagactctgcgtctgcagatg
aacttcatcaaccaggcccagctcggcatcttcagggccttccctggcctgcgctacgtg
gacctgtcggacaaccgcatcagcggagcttcggagctgacagccaccatgggggaggca
gatggaggggagaaggtctggctgcagcctggggaccttgctccggccccagtggacact
cccagctctgaagacttcaggcccaactgcagcaccctcaacttcaccttggatctgtca
cggaacaacctggtgaccgtgcagccggagatgtttgcccagctctcgcacctgcagtgc
ctgcgcctgagccacaactgcatctcgcaggcagtcaatggctcccagttcctgccgctg
accggtctgcaggtgctagacctgtcccacaataagctggacctctaccacgagcactca
ttcacggagctaccgcgactggaggccctggacctcagctacaacagccagccctttggc
atgcagggcgtgggccacaacttcagcttcgtggctcacctgcgcaccctgcgccacctc
agcctggcccacaacaacatccacagccaagtgtcccagcagctctgcagtacgtcgctg
cgggccctggacttcagcggcaatgcactgggccatatgtgggccgagggagacctctat
ctgcacttcttccaaggcctgagcggtttgatctggctggacttgtcccagaaccgcctg
cacaccctcctgccccaaaccctgcgcaacctccccaagagcctacaggtgctgcgtctc
cgtgacaattacctggccttctttaagtggtggagcctccacttcctgcccaaactggaa
gtcctcgacctggcaggaaaccagctgaaggccctgaccaatggcagcctgcctgctggc
acccggctccggaggctggatgtcagctgcaacagcatcagcttcgtggcccccggcttc
ttttccaaggccaaggagctgcgagagctcaaccttagcgccaacgccctcaagacagtg
gaccactcctggtttgggcccctggcgagtgccctgcaaatactagatgtaagcgccaac
cctctgcactgcgcctgtggggcggcctttatggacttcctgctggaggtgcaggctgcc
gtgcccggtctgcccagccgggtgaagtgtggcagtccgggccagctccagggcctcagc
atctttgcacaggacctgcgcctctgcctggatgaggccctctcctgggactgtttcgcc
ctctcgctgctggctgtggctctgggcctgggtgtgcccatgctgcatcacctctgtggc
tgggacctctggtactgcttccacctgtgcctggcctggcttccctggcgggggcggcaa
agtgggcgagatgaggatgccctgccctacgatgccttcgtggtcttcgacaaaacgcag
agcgcagtggcagactgggtgtacaacgagcttcgggggcagctggaggagtgccgtggg
cgctgggcactccgcctgtgcctggaggaacgcgactggctgcctggcaaaaccctcttt
gagaacctgtgggcctcggtctatggcagccgcaagacgctgtttgtgctggcccacacg
gaccgggtcagtggtctcttgcgcgccagcttcctgctggcccagcagcgcctgctggag
gaccgcaaggacgtcgtggtgctggtgatcctgagccctgacggccgccgctcccgctac
gtgcggctgcgccagcgcctctgccgccagagtgtcctcctctggccccaccagcccagt
ggtcagcgcagcttctgggcccagctgggcatggccctgaccagggacaaccaccacttc
tataaccggaacttctgccagggacccacggccgaatag

KEGG   Homo sapiens (human): 7097
Entry
7097              CDS       T01001                                 
Symbol
TLR2, CD282, TIL4
Name
(RefSeq) toll like receptor 2
  KO
K10159  toll-like receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa05132  Salmonella infection
hsa05134  Legionellosis
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05205  Proteoglycans in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
  Element
N00435  TLR1/2/4-NFKB signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00556  HBV HBe to TLR2/4-NFKB signaling pathway
Disease
H00342  Tuberculosis
H00344  Leprosy
Drug target
Tomaralimab: D11503
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    7097 (TLR2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7097 (TLR2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    7097 (TLR2)
   04620 Toll-like receptor signaling pathway
    7097 (TLR2)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7097 (TLR2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    7097 (TLR2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    7097 (TLR2)
   05161 Hepatitis B
    7097 (TLR2)
   05171 Coronavirus disease - COVID-19
    7097 (TLR2)
   05162 Measles
    7097 (TLR2)
   05168 Herpes simplex virus 1 infection
    7097 (TLR2)
   05169 Epstein-Barr virus infection
    7097 (TLR2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    7097 (TLR2)
   05134 Legionellosis
    7097 (TLR2)
   05152 Tuberculosis
    7097 (TLR2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7097 (TLR2)
   05144 Malaria
    7097 (TLR2)
   05145 Toxoplasmosis
    7097 (TLR2)
   05140 Leishmaniasis
    7097 (TLR2)
   05142 Chagas disease
    7097 (TLR2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7097 (TLR2)
   05321 Inflammatory bowel disease
    7097 (TLR2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7097 (TLR2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7097 (TLR2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7097 (TLR2)
   04054 Pattern recognition receptors [BR:hsa04054]
    7097 (TLR2)
   04090 CD molecules [BR:hsa04090]
    7097 (TLR2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7097 (TLR2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    7097 (TLR2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast milk
   7097 (TLR2)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   7097 (TLR2)
CD molecules [BR:hsa04090]
 Proteins
  7097 (TLR2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Hyaluronan
  Cell surface receptors
   7097 (TLR2)
SSDB
Motif
Pfam: LRR_8 LRR_4 TIR TIR_2 LRR_9 LRR_5 LRR_1 LRRCT TANGO2
Other DBs
NCBI-GeneID: 7097
NCBI-ProteinID: NP_001305716
OMIM: 603028
HGNC: 11848
Ensembl: ENSG00000137462
UniProt: O60603 A0A0S2Z4S4 B3KWR9
Structure
LinkDB
Position
4:153684280..153710637
AA seq 784 aa
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
AIKS
NT seq 2355 nt   +upstreamnt  +downstreamnt
atgccacatactttgtggatggtgtgggtcttgggggtcatcatcagcctctccaaggaa
gaatcctccaatcaggcttctctgtcttgtgaccgcaatggtatctgcaagggcagctca
ggatctttaaactccattccctcagggctcacagaagctgtaaaaagccttgacctgtcc
aacaacaggatcacctacattagcaacagtgacctacagaggtgtgtgaacctccaggct
ctggtgctgacatccaatggaattaacacaatagaggaagattctttttcttccctgggc
agtcttgaacatttagacttatcctataattacttatctaatttatcgtcttcctggttc
aagcccctttcttctttaacattcttaaacttactgggaaatccttacaaaaccctaggg
gaaacatctcttttttctcatctcacaaaattgcaaatcctgagagtgggaaatatggac
accttcactaagattcaaagaaaagattttgctggacttaccttccttgaggaacttgag
attgatgcttcagatctacagagctatgagccaaaaagtttgaagtcaattcagaatgta
agtcatctgatccttcatatgaagcagcatattttactgctggagatttttgtagatgtt
acaagttccgtggaatgtttggaactgcgagatactgatttggacactttccatttttca
gaactatccactggtgaaacaaattcattgattaaaaagtttacatttagaaatgtgaaa
atcaccgatgaaagtttgtttcaggttatgaaacttttgaatcagatttctggattgtta
gaattagagtttgatgactgtacccttaatggagttggtaattttagagcatctgataat
gacagagttatagatccaggtaaagtggaaacgttaacaatccggaggctgcatattcca
aggttttacttattttatgatctgagcactttatattcacttacagaaagagttaaaaga
atcacagtagaaaacagtaaagtttttctggttccttgtttactttcacaacatttaaaa
tcattagaatacttggatctcagtgaaaatttgatggttgaagaatacttgaaaaattca
gcctgtgaggatgcctggccctctctacaaactttaattttaaggcaaaatcatttggca
tcattggaaaaaaccggagagactttgctcactctgaaaaacttgactaacattgatatc
agtaagaatagttttcattctatgcctgaaacttgtcagtggccagaaaagatgaaatat
ttgaacttatccagcacacgaatacacagtgtaacaggctgcattcccaagacactggaa
attttagatgttagcaacaacaatctcaatttattttctttgaatttgccgcaactcaaa
gaactttatatttccagaaataagttgatgactctaccagatgcctccctcttacccatg
ttactagtattgaaaatcagtaggaatgcaataactacgttttctaaggagcaacttgac
tcatttcacacactgaagactttggaagctggtggcaataacttcatttgctcctgtgaa
ttcctctccttcactcaggagcagcaagcactggccaaagtcttgattgattggccagca
aattacctgtgtgactctccatcccatgtgcgtggccagcaggttcaggatgtccgcctc
tcggtgtcggaatgtcacaggacagcactggtgtctggcatgtgctgtgctctgttcctg
ctgatcctgctcacgggggtcctgtgccaccgtttccatggcctgtggtatatgaaaatg
atgtgggcctggctccaggccaaaaggaagcccaggaaagctcccagcaggaacatctgc
tatgatgcatttgtttcttacagtgagcgggatgcctactgggtggagaaccttatggtc
caggagctggagaacttcaatccccccttcaagttgtgtcttcataagcgggacttcatt
cctggcaagtggatcattgacaatatcattgactccattgaaaagagccacaaaactgtc
tttgtgctttctgaaaactttgtgaagagtgagtggtgcaagtatgaactggacttctcc
catttccgtctttttgatgagaacaatgatgctgccattctcattcttctggagcccatt
gagaaaaaagccattccccagcgcttctgcaagctgcggaagataatgaacaccaagacc
tacctggagtggcccatggacgaggctcagcgggaaggattttgggtaaatctgagagct
gcgataaagtcctag

KEGG   Homo sapiens (human): 7099
Entry
7099              CDS       T01001                                 
Symbol
TLR4, ARMD10, CD284, TLR-4, TOLL
Name
(RefSeq) toll like receptor 4
  KO
K10160  toll-like receptor 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04936  Alcoholic liver disease
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05205  Proteoglycans in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06527  Necroptosis
  Element
N00435  TLR1/2/4-NFKB signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00553  TLR4-IRF3/7 signaling pathway
N01634  TLR4-RIPK3 signaling pathway
Disease
H00821  Age-related macular degeneration
Drug target
Eritoran (DG01426): D04043 D09573
Mifamurtide: D06619
Mosedipimod: D11668
Paridiprubart: D12624
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    7099 (TLR4)
   04066 HIF-1 signaling pathway
    7099 (TLR4)
   04151 PI3K-Akt signaling pathway
    7099 (TLR4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7099 (TLR4)
  09143 Cell growth and death
   04217 Necroptosis
    7099 (TLR4)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    7099 (TLR4)
   04620 Toll-like receptor signaling pathway
    7099 (TLR4)
   04621 NOD-like receptor signaling pathway
    7099 (TLR4)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7099 (TLR4)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    7099 (TLR4)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    7099 (TLR4)
   05161 Hepatitis B
    7099 (TLR4)
   05171 Coronavirus disease - COVID-19
    7099 (TLR4)
   05164 Influenza A
    7099 (TLR4)
   05162 Measles
    7099 (TLR4)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7099 (TLR4)
   05132 Salmonella infection
    7099 (TLR4)
   05131 Shigellosis
    7099 (TLR4)
   05135 Yersinia infection
    7099 (TLR4)
   05133 Pertussis
    7099 (TLR4)
   05134 Legionellosis
    7099 (TLR4)
   05152 Tuberculosis
    7099 (TLR4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7099 (TLR4)
   05144 Malaria
    7099 (TLR4)
   05145 Toxoplasmosis
    7099 (TLR4)
   05140 Leishmaniasis
    7099 (TLR4)
   05142 Chagas disease
    7099 (TLR4)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7099 (TLR4)
   05321 Inflammatory bowel disease
    7099 (TLR4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7099 (TLR4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    7099 (TLR4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7099 (TLR4)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    7099 (TLR4)
   04090 CD molecules [BR:hsa04090]
    7099 (TLR4)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7099 (TLR4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    7099 (TLR4)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   7099 (TLR4)
CD molecules [BR:hsa04090]
 Proteins
  7099 (TLR4)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Hyaluronan
  Cell surface receptors
   7099 (TLR4)
SSDB
Motif
Pfam: LRR_8 TIR LRR_4 LRR_1 TIR_2 LRR_9 LRR_Zer-1 LRR_6 LRR_EndoS LRR_R13L1-DRL21 ThsB_TIR Pentapeptide_4
Other DBs
NCBI-GeneID: 7099
NCBI-ProteinID: NP_612564
OMIM: 603030
HGNC: 11850
Ensembl: ENSG00000136869
UniProt: O00206
Structure
LinkDB
Position
9:117704403..117724735
AA seq 839 aa
MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
NT seq 2520 nt   +upstreamnt  +downstreamnt
atgatgtctgcctcgcgcctggctgggactctgatcccagccatggccttcctctcctgc
gtgagaccagaaagctgggagccctgcgtggaggtggttcctaatattacttatcaatgc
atggagctgaatttctacaaaatccccgacaacctccccttctcaaccaagaacctggac
ctgagctttaatcccctgaggcatttaggcagctatagcttcttcagtttcccagaactg
caggtgctggatttatccaggtgtgaaatccagacaattgaagatggggcatatcagagc
ctaagccacctctctaccttaatattgacaggaaaccccatccagagtttagccctggga
gccttttctggactatcaagtttacagaagctggtggctgtggagacaaatctagcatct
ctagagaacttccccattggacatctcaaaactttgaaagaacttaatgtggctcacaat
cttatccaatctttcaaattacctgagtatttttctaatctgaccaatctagagcacttg
gacctttccagcaacaagattcaaagtatttattgcacagacttgcgggttctacatcaa
atgcccctactcaatctctctttagacctgtccctgaaccctatgaactttatccaacca
ggtgcatttaaagaaattaggcttcataagctgactttaagaaataattttgatagttta
aatgtaatgaaaacttgtattcaaggtctggctggtttagaagtccatcgtttggttctg
ggagaatttagaaatgaaggaaacttggaaaagtttgacaaatctgctctagagggcctg
tgcaatttgaccattgaagaattccgattagcatacttagactactacctcgatgatatt
attgacttatttaattgtttgacaaatgtttcttcattttccctggtgagtgtgactatt
gaaagggtaaaagacttttcttataatttcggatggcaacatttagaattagttaactgt
aaatttggacagtttcccacattgaaactcaaatctctcaaaaggcttactttcacttcc
aacaaaggtgggaatgctttttcagaagttgatctaccaagccttgagtttctagatctc
agtagaaatggcttgagtttcaaaggttgctgttctcaaagtgattttgggacaaccagc
ctaaagtatttagatctgagcttcaatggtgttattaccatgagttcaaacttcttgggc
ttagaacaactagaacatctggatttccagcattccaatttgaaacaaatgagtgagttt
tcagtattcctatcactcagaaacctcatttaccttgacatttctcatactcacaccaga
gttgctttcaatggcatcttcaatggcttgtccagtctcgaagtcttgaaaatggctggc
aattctttccaggaaaacttccttccagatatcttcacagagctgagaaacttgaccttc
ctggacctctctcagtgtcaactggagcagttgtctccaacagcatttaactcactctcc
agtcttcaggtactaaatatgagccacaacaacttcttttcattggatacgtttccttat
aagtgtctgaactccctccaggttcttgattacagtctcaatcacataatgacttccaaa
aaacaggaactacagcattttccaagtagtctagctttcttaaatcttactcagaatgac
tttgcttgtacttgtgaacaccagagtttcctgcaatggatcaaggaccagaggcagctc
ttggtggaagttgaacgaatggaatgtgcaacaccttcagataagcagggcatgcctgtg
ctgagtttgaatatcacctgtcagatgaataagaccatcattggtgtgtcggtcctcagt
gtgcttgtagtatctgttgtagcagttctggtctataagttctattttcacctgatgctt
cttgctggctgcataaagtatggtagaggtgaaaacatctatgatgcctttgttatctac
tcaagccaggatgaggactgggtaaggaatgagctagtaaagaatttagaagaaggggtg
cctccatttcagctctgccttcactacagagactttattcccggtgtggccattgctgcc
aacatcatccatgaaggtttccataaaagccgaaaggtgattgttgtggtgtcccagcac
ttcatccagagccgctggtgtatctttgaatatgagattgctcagacctggcagtttctg
agcagtcgtgctggtatcatcttcattgtcctgcagaaggtggagaagaccctgctcagg
cagcaggtggagctgtaccgccttctcagcaggaacacttacctggagtgggaggacagt
gtcctggggcggcacatcttctggagacgactcagaaaagccctgctggatggtaaatca
tggaatccagaaggaacagtgggtacaggatgcaattggcaggaagcaacatctatctga

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