Entry |
|
Symbol |
TLR4, ARMD10, CD284, TLR-4, TOLL
|
Name |
(RefSeq) toll like receptor 4
|
KO |
|
Organism |
|
Pathway |
hsa04613 | Neutrophil extracellular trap formation |
hsa04620 | Toll-like receptor signaling pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Network |
nt06121 TLR signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06165 Epstein-Barr virus (EBV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06263 Hepatocellular carcinoma |
Element |
N00435 | TLR2/4-NFKB signaling pathway |
N00438 | TLR2/4-MAPK signaling pathway |
N00553 | TLR4-IRF3/7 signaling pathway |
|
Disease |
H00821 | Age-related macular degeneration |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
7099 (TLR4)
04066 HIF-1 signaling pathway
7099 (TLR4)
04151 PI3K-Akt signaling pathway
7099 (TLR4)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
7099 (TLR4)
09143 Cell growth and death
04217 Necroptosis
7099 (TLR4)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
7099 (TLR4)
04620 Toll-like receptor signaling pathway
7099 (TLR4)
04621 NOD-like receptor signaling pathway
7099 (TLR4)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
7099 (TLR4)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
7099 (TLR4)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
7099 (TLR4)
05161 Hepatitis B
7099 (TLR4)
05171 Coronavirus disease - COVID-19
7099 (TLR4)
05164 Influenza A
7099 (TLR4)
05162 Measles
7099 (TLR4)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
7099 (TLR4)
05132 Salmonella infection
7099 (TLR4)
05131 Shigellosis
7099 (TLR4)
05135 Yersinia infection
7099 (TLR4)
05133 Pertussis
7099 (TLR4)
05134 Legionellosis
7099 (TLR4)
05152 Tuberculosis
7099 (TLR4)
09174 Infectious disease: parasitic
05146 Amoebiasis
7099 (TLR4)
05144 Malaria
7099 (TLR4)
05145 Toxoplasmosis
7099 (TLR4)
05140 Leishmaniasis
7099 (TLR4)
05142 Chagas disease
7099 (TLR4)
09163 Immune disease
05323 Rheumatoid arthritis
7099 (TLR4)
05321 Inflammatory bowel disease
7099 (TLR4)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
7099 (TLR4)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
7099 (TLR4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
7099 (TLR4)
09183 Protein families: signaling and cellular processes
04054 Pattern recognition receptors [BR:hsa04054]
7099 (TLR4)
04090 CD molecules [BR:hsa04090]
7099 (TLR4)
00536 Glycosaminoglycan binding proteins [BR:hsa00536]
7099 (TLR4)
Membrane trafficking [BR:hsa04131]
Endocytosis
Phagocytosis
Toll-like receptors
7099 (TLR4)
Pattern recognition receptors [BR:hsa04054]
Membrane-bound pattern recognition receptors
Toll-like receptors
7099 (TLR4)
CD molecules [BR:hsa04090]
Proteins
7099 (TLR4)
Glycosaminoglycan binding proteins [BR:hsa00536]
Hyaluronan
Cell surface receptors
7099 (TLR4)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
9:117704403..117724735
|
AA seq |
839 aa
MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI |
NT seq |
2520 nt +upstreamnt +downstreamnt
atgatgtctgcctcgcgcctggctgggactctgatcccagccatggccttcctctcctgc
gtgagaccagaaagctgggagccctgcgtggaggtggttcctaatattacttatcaatgc
atggagctgaatttctacaaaatccccgacaacctccccttctcaaccaagaacctggac
ctgagctttaatcccctgaggcatttaggcagctatagcttcttcagtttcccagaactg
caggtgctggatttatccaggtgtgaaatccagacaattgaagatggggcatatcagagc
ctaagccacctctctaccttaatattgacaggaaaccccatccagagtttagccctggga
gccttttctggactatcaagtttacagaagctggtggctgtggagacaaatctagcatct
ctagagaacttccccattggacatctcaaaactttgaaagaacttaatgtggctcacaat
cttatccaatctttcaaattacctgagtatttttctaatctgaccaatctagagcacttg
gacctttccagcaacaagattcaaagtatttattgcacagacttgcgggttctacatcaa
atgcccctactcaatctctctttagacctgtccctgaaccctatgaactttatccaacca
ggtgcatttaaagaaattaggcttcataagctgactttaagaaataattttgatagttta
aatgtaatgaaaacttgtattcaaggtctggctggtttagaagtccatcgtttggttctg
ggagaatttagaaatgaaggaaacttggaaaagtttgacaaatctgctctagagggcctg
tgcaatttgaccattgaagaattccgattagcatacttagactactacctcgatgatatt
attgacttatttaattgtttgacaaatgtttcttcattttccctggtgagtgtgactatt
gaaagggtaaaagacttttcttataatttcggatggcaacatttagaattagttaactgt
aaatttggacagtttcccacattgaaactcaaatctctcaaaaggcttactttcacttcc
aacaaaggtgggaatgctttttcagaagttgatctaccaagccttgagtttctagatctc
agtagaaatggcttgagtttcaaaggttgctgttctcaaagtgattttgggacaaccagc
ctaaagtatttagatctgagcttcaatggtgttattaccatgagttcaaacttcttgggc
ttagaacaactagaacatctggatttccagcattccaatttgaaacaaatgagtgagttt
tcagtattcctatcactcagaaacctcatttaccttgacatttctcatactcacaccaga
gttgctttcaatggcatcttcaatggcttgtccagtctcgaagtcttgaaaatggctggc
aattctttccaggaaaacttccttccagatatcttcacagagctgagaaacttgaccttc
ctggacctctctcagtgtcaactggagcagttgtctccaacagcatttaactcactctcc
agtcttcaggtactaaatatgagccacaacaacttcttttcattggatacgtttccttat
aagtgtctgaactccctccaggttcttgattacagtctcaatcacataatgacttccaaa
aaacaggaactacagcattttccaagtagtctagctttcttaaatcttactcagaatgac
tttgcttgtacttgtgaacaccagagtttcctgcaatggatcaaggaccagaggcagctc
ttggtggaagttgaacgaatggaatgtgcaacaccttcagataagcagggcatgcctgtg
ctgagtttgaatatcacctgtcagatgaataagaccatcattggtgtgtcggtcctcagt
gtgcttgtagtatctgttgtagcagttctggtctataagttctattttcacctgatgctt
cttgctggctgcataaagtatggtagaggtgaaaacatctatgatgcctttgttatctac
tcaagccaggatgaggactgggtaaggaatgagctagtaaagaatttagaagaaggggtg
cctccatttcagctctgccttcactacagagactttattcccggtgtggccattgctgcc
aacatcatccatgaaggtttccataaaagccgaaaggtgattgttgtggtgtcccagcac
ttcatccagagccgctggtgtatctttgaatatgagattgctcagacctggcagtttctg
agcagtcgtgctggtatcatcttcattgtcctgcagaaggtggagaagaccctgctcagg
cagcaggtggagctgtaccgccttctcagcaggaacacttacctggagtgggaggacagt
gtcctggggcggcacatcttctggagacgactcagaaaagccctgctggatggtaaatca
tggaatccagaaggaacagtgggtacaggatgcaattggcaggaagcaacatctatctga |