KEGG T01001: 7448

Homo sapiens (human): 7448

Entry

7448              CDS       T01001

Symbol

VTN, V75, VN, VNT

Name

(RefSeq) vitronectin

K06251

vitronectin

Organism

hsa Homo sapiens (human)

Pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04512

ECM-receptor interaction

hsa04518

Integrin signaling

hsa04610

Complement and coagulation cascades

hsa05165

Human papillomavirus infection

hsa05205

Proteoglycans in cancer

Network

nt06513 Complement cascade
nt06548 Integrin signaling

Element

N01505

Regulation of complement cascade, MAC inhibition

N01979

Integrin alphaIIbbeta3 signaling

N01981

Integrin alpha8beta1 signaling

N01982

Integrin alphaVbeta1 signaling

N01983

Integrin alphaVbeta3 signaling

N01984

Integrin alphaVbeta5 signaling

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    7448 (VTN)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    7448 (VTN)
   04518 Integrin signaling
    7448 (VTN)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7448 (VTN)
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    7448 (VTN)
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7448 (VTN)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7448 (VTN)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7448 (VTN)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7448 (VTN)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   7448 (VTN)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   7448 (VTN)

SSDB

Motif

Pfam:

Hemopexin Somatomedin_B

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(28367284..28370307)

AA seq 478 aa
MAPLRPLLILALLAWVALADQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKP
QVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLTSDLQAQSKGNPEQTPVLKPEE
EAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYC
YELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYP
RNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSA
VFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQFISRDWHGVPGQVDAAMAGRIYISGMA
PRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQNSRRPSRATWLSLFSSEESNLGANNYDDY
RMDWLVPATCEPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAPGHL

NT seq 1437 nt +upstreamnt +downstreamnt
atggcacccctgagaccccttctcatactggccctgctggcatgggttgctctggctgac
caagagtcatgcaagggccgctgcactgagggcttcaacgtggacaagaagtgccagtgt
gacgagctctgctcttactaccagagctgctgcacagactatacggctgagtgcaagccc
caagtgactcgcggggatgtgttcactatgccggaggatgagtacacggtctatgacgat
ggcgaggagaaaaacaatgccactgtccatgaacaggtggggggcccctccctgacctct
gacctccaggcccagtccaaagggaatcctgagcagacacctgttctgaaacctgaggaa
gaggcccctgcgcctgaggtgggcgcctctaagcctgaggggatagactcaaggcctgag
acccttcatccagggagacctcagcccccagcagaggaggagctgtgcagtgggaagccc
ttcgacgccttcaccgacctcaagaacggttccctctttgccttccgagggcagtactgc
tatgaactggacgaaaaggcagtgaggcctgggtaccccaagctcatccgagatgtctgg
ggcatcgagggccccatcgatgccgccttcacccgcatcaactgtcaggggaagacctac
ctcttcaagggtagtcagtactggcgctttgaggatggtgtcctggaccctgattacccc
cgaaatatctctgacggcttcgatggcatcccggacaacgtggatgcagccttggccctc
cctgcccatagctacagtggccgggagcgggtctacttcttcaaggggaaacagtactgg
gagtaccagttccagcaccagcccagtcaggaggagtgtgaaggcagctccctgtcggct
gtgtttgaacactttgccatgatgcagcgggacagctgggaggacatcttcgagcttctc
ttctggggcagaacctctgctggtaccagacagccccagttcattagccgggactggcac
ggtgtgccagggcaagtggacgcagccatggctggccgcatctacatctcaggcatggca
ccccgcccctccttggccaagaaacaaaggtttaggcatcgcaaccgcaaaggctaccgt
tcacaacgaggccacagccgtggccgcaaccagaactcccgccggccatcccgcgccacg
tggctgtccttgttctccagtgaggagagcaacttgggagccaacaactatgatgactac
aggatggactggcttgtgcctgccacctgtgaacccatccagagtgtcttcttcttctct
ggagacaagtactaccgagtcaatcttcgcacacggcgagtggacactgtggaccctccc
tacccacgctccatcgctcagtactggctgggctgcccagctcctggccatctgtag

Homo sapiens (human): 3381

Entry

3381              CDS       T01001

Symbol

IBSP, BNSP, BSP, BSP-II, SP-II

Name

(RefSeq) integrin binding sialoprotein

K06253

integrin binding sialoprotein

Organism

hsa Homo sapiens (human)

Pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04512

ECM-receptor interaction

hsa04518

Integrin signaling

hsa05165

Human papillomavirus infection

Network

nt06548 Integrin signaling

Element

N01984

Integrin alphaVbeta5 signaling

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    3381 (IBSP)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    3381 (IBSP)
   04518 Integrin signaling
    3381 (IBSP)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3381 (IBSP)
09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    3381 (IBSP)

SSDB

Motif

Pfam:

BSP_II Utp14

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

4:87799554..87812435

AA seq 317 aa
MKTALILLSILGMACAFSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRFPV
QGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEAENTTLSATTLGYGEDATP
GTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTS
TNSTEAENGNGSSGGDNGEEGEEESVTGANAEDTTETGRQGKGTSKTTTSPNGGFEPTTP
PQVYRTTSPPFGKTTTVEYEGEYEYTGANEYDNGYEIYESENGEPRGDNYRAYEDEYSYF
KGQGYDGYDGQNYYHHQ

NT seq 954 nt +upstreamnt +downstreamnt
atgaagactgctttaattttgctcagcattttgggaatggcctgtgctttctcaatgaaa
aatttgcatcgaagagtcaaaatagaggattctgaagaaaatggggtctttaagtacagg
ccacgatattatctttacaagcatgcctacttttatcctcatttaaaacgatttccagtt
cagggcagtagtgactcatccgaagaaaatggagatgacagttcagaagaggaggaggaa
gaagaggagacttcaaatgaaggagaaaacaatgaagaatcgaatgaagatgaagactct
gaggctgagaataccacactttctgctacaacactgggctatggagaggacgccacgcct
ggcacagggtatacagggttagctgcaatccagcttcccaagaaggctggggatataaca
aataaagctacaaaagagaaggaaagtgatgaagaagaagaggaggaagaggaaggaaat
gaaaacgaagaaagcgaagcagaagtggatgaaaacgaacaaggcataaacggcaccagt
accaacagcacagaggcagaaaacggcaacggcagcagcggaggagacaatggagaagaa
ggggaagaagaaagtgtcactggagccaatgcagaagacaccacagagaccggaaggcag
ggcaagggcacctcgaagacaacaacctctccaaatggtgggtttgaacctacaacccca
ccacaagtctatagaaccacttccccaccttttgggaaaaccaccaccgttgaatacgag
ggggagtacgaatacacgggcgccaatgaatacgacaatggatatgaaatctatgaaagt
gagaacggggaacctcgtggggacaattaccgagcctatgaagatgagtacagctacttt
aaaggacaaggctacgatggctatgatggtcagaattactaccaccaccagtga

Homo sapiens (human): 6696

Entry

6696              CDS       T01001

Symbol

SPP1, BNSP, BSPI, ETA-1, OPN

Name

(RefSeq) secreted phosphoprotein 1

K06250

secreted phosphoprotein 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04151

PI3K-Akt signaling pathway

hsa04371

Apelin signaling pathway

hsa04510

Focal adhesion

hsa04512

ECM-receptor interaction

hsa04518

Integrin signaling

hsa04620

Toll-like receptor signaling pathway

hsa04929

GnRH secretion

hsa05165

Human papillomavirus infection

Network

nt06548 Integrin signaling

Element

N01921

Integrin alpha4beta1 signaling

N01973

Integrin alpha4beta7 signaling

N01974

Integrin alpha9beta1 signaling

N01980

Integrin alpha5beta1 signaling

N01982

Integrin alphaVbeta1 signaling

N01983

Integrin alphaVbeta3 signaling

N01984

Integrin alphaVbeta5 signaling

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    6696 (SPP1)
   04151 PI3K-Akt signaling pathway
    6696 (SPP1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    6696 (SPP1)
   04518 Integrin signaling
    6696 (SPP1)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    6696 (SPP1)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    6696 (SPP1)
  09152 Endocrine system
   04929 GnRH secretion
    6696 (SPP1)
09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    6696 (SPP1)

SSDB

Motif

Pfam:

Osteopontin

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

4:87975714..87983411

AA seq 314 aa
MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNA
VSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQS
DESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQ
YPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSH
KQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKF
RISHELDSASSEVN

NT seq 945 nt +upstreamnt +downstreamnt
atgagaattgcagtgatttgcttttgcctcctaggcatcacctgtgccataccagttaaa
caggctgattctggaagttctgaggaaaagcagctttacaacaaatacccagatgctgtg
gccacatggctaaaccctgacccatctcagaagcagaatctcctagccccacagaatgct
gtgtcctctgaagaaaccaatgactttaaacaagagacccttccaagtaagtccaacgaa
agccatgaccacatggatgatatggatgatgaagatgatgatgaccatgtggacagccag
gactccattgactcgaacgactctgatgatgtagatgacactgatgattctcaccagtct
gatgagtctcaccattctgatgaatctgatgaactggtcactgattttcccacggacctg
ccagcaaccgaagttttcactccagttgtccccacagtagacacatatgatggccgaggt
gatagtgtggtttatggactgaggtcaaaatctaagaagtttcgcagacctgacatccag
taccctgatgctacagacgaggacatcacctcacacatggaaagcgaggagttgaatggt
gcatacaaggccatccccgttgcccaggacctgaacgcgccttctgattgggacagccgt
gggaaggacagttatgaaacgagtcagctggatgaccagagtgctgaaacccacagccac
aagcagtccagattatataagcggaaagccaatgatgagagcaatgagcattccgatgtg
attgatagtcaggaactttccaaagtcagccgtgaattccacagccatgaatttcacagc
catgaagatatgctggttgtagaccccaaaagtaaggaagaagataaacacctgaaattt
cgtatttctcatgaattagatagtgcatcttctgaggtcaattaa

Homo sapiens (human): 7040

Entry

7040              CDS       T01001

Symbol

TGFB1, CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta

Name

(RefSeq) transforming growth factor beta 1

K13375

transforming growth factor beta-1

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04068

FoxO signaling pathway

hsa04110

Cell cycle

hsa04148

Efferocytosis

hsa04218

Cellular senescence

hsa04350

TGF-beta signaling pathway

hsa04380

Osteoclast differentiation

hsa04390

Hippo signaling pathway

hsa04518

Integrin signaling

hsa04659

Th17 cell differentiation

hsa04672

Intestinal immune network for IgA production

hsa04926

Relaxin signaling pathway

hsa04932

Non-alcoholic fatty liver disease

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa05140

Leishmaniasis

hsa05142

Chagas disease

hsa05144

Malaria

hsa05145

Toxoplasmosis

hsa05146

Amoebiasis

hsa05152

Tuberculosis

hsa05161

Hepatitis B

hsa05166

Human T-cell leukemia virus 1 infection

hsa05200

Pathways in cancer

hsa05205

Proteoglycans in cancer

hsa05210

Colorectal cancer

hsa05211

Renal cell carcinoma

hsa05212

Pancreatic cancer

hsa05220

Chronic myeloid leukemia

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

hsa05321

Inflammatory bowel disease

hsa05323

Rheumatoid arthritis

hsa05410

Hypertrophic cardiomyopathy

hsa05414

Dilated cardiomyopathy

hsa05415

Diabetic cardiomyopathy

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06218  TGFB signaling (cancer)
nt06225  HIF-1 signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06276  Chronic myeloid leukemia
nt06507  TGFB signaling
nt06535  Efferocytosis
nt06542  HIF signaling
nt06548  Integrin signaling

Element

N00063

TGF-beta signaling pathway

N00079

HIF-1 signaling pathway

N00080

Loss of VHL to HIF-1 signaling pathway

N00081

Mutation-inactivated VHL to HIF-1 signaling pathway

N00531

HBV HBx to TGF-beta signaling pathway

N01460

Plasmin mediated activation of latent TGF-beta

N01773

PTGS2-PGE2-TGFB1 pathway

N01781

Activation of LXRs by oxysterols

N01980

Integrin alpha5beta1 signaling

N01981

Integrin alpha8beta1 signaling

N01983

Integrin alphaVbeta3 signaling

N01984

Integrin alphaVbeta5 signaling

N01985

Integrin alphaVbeta6 signaling

N01986

Integrin alphaVbeta8 signaling

Disease

H00083

Allograft rejection

H00084

Graft-versus-host disease

H00218

Cystic fibrosis

H00434

Camurati-Engelmann disease

H02669

Inflammatory bowel disease, immunodeficiency, and encephalopathy

Drug target

Fresolimumab:

D09620

Linavonkibart:

D12801

Livmoniplimab:

D12793

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7040 (TGFB1)
   04350 TGF-beta signaling pathway
    7040 (TGFB1)
   04390 Hippo signaling pathway
    7040 (TGFB1)
   04068 FoxO signaling pathway
    7040 (TGFB1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    7040 (TGFB1)
   04518 Integrin signaling
    7040 (TGFB1)
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    7040 (TGFB1)
  09143 Cell growth and death
   04110 Cell cycle
    7040 (TGFB1)
   04218 Cellular senescence
    7040 (TGFB1)
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    7040 (TGFB1)
   04672 Intestinal immune network for IgA production
    7040 (TGFB1)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    7040 (TGFB1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7040 (TGFB1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7040 (TGFB1)
   05205 Proteoglycans in cancer
    7040 (TGFB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    7040 (TGFB1)
   05212 Pancreatic cancer
    7040 (TGFB1)
   05225 Hepatocellular carcinoma
    7040 (TGFB1)
   05226 Gastric cancer
    7040 (TGFB1)
   05220 Chronic myeloid leukemia
    7040 (TGFB1)
   05211 Renal cell carcinoma
    7040 (TGFB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7040 (TGFB1)
   05161 Hepatitis B
    7040 (TGFB1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    7040 (TGFB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7040 (TGFB1)
   05144 Malaria
    7040 (TGFB1)
   05145 Toxoplasmosis
    7040 (TGFB1)
   05140 Leishmaniasis
    7040 (TGFB1)
   05142 Chagas disease
    7040 (TGFB1)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7040 (TGFB1)
   05321 Inflammatory bowel disease
    7040 (TGFB1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7040 (TGFB1)
   05414 Dilated cardiomyopathy
    7040 (TGFB1)
   05415 Diabetic cardiomyopathy
    7040 (TGFB1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    7040 (TGFB1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    7040 (TGFB1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    7040 (TGFB1)
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    7040 (TGFB1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7040 (TGFB1)
Chaperones and folding catalysts [BR:hsa03110]
Intramolecular chaperones
  Others
   7040 (TGFB1)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Transforming growth factors (RSTK binding)
   7040 (TGFB1)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   7040 (TGFB1)

SSDB

Motif

Pfam:

TGFb_propeptide TGF_beta

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

19:complement(41330323..41353922)

AA seq 390 aa
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

NT seq 1173 nt +upstreamnt +downstreamnt
atgccgccctccgggctgcggctgctgccgctgctgctaccgctgctgtggctactggtg
ctgacgcctggccggccggccgcgggactatccacctgcaagactatcgacatggagctg
gtgaagcggaagcgcatcgaggccatccgcggccagatcctgtccaagctgcggctcgcc
agccccccgagccagggggaggtgccgcccggcccgctgcccgaggccgtgctcgccctg
tacaacagcacccgcgaccgggtggccggggagagtgcagaaccggagcccgagcctgag
gccgactactacgccaaggaggtcacccgcgtgctaatggtggaaacccacaacgaaatc
tatgacaagttcaagcagagtacacacagcatatatatgttcttcaacacatcagagctc
cgagaagcggtacctgaacccgtgttgctctcccgggcagagctgcgtctgctgaggctc
aagttaaaagtggagcagcacgtggagctgtaccagaaatacagcaacaattcctggcga
tacctcagcaaccggctgctggcacccagcgactcgccagagtggttatcttttgatgtc
accggagttgtgcggcagtggttgagccgtggaggggaaattgagggctttcgccttagc
gcccactgctcctgtgacagcagggataacacactgcaagtggacatcaacgggttcact
accggccgccgaggtgacctggccaccattcatggcatgaaccggcctttcctgcttctc
atggccaccccgctggagagggcccagcatctgcaaagctcccggcaccgccgagccctg
gacaccaactattgcttcagctccacggagaagaactgctgcgtgcggcagctgtacatt
gacttccgcaaggacctcggctggaagtggatccacgagcccaagggctaccatgccaac
ttctgcctcgggccctgcccctacatttggagcctggacacgcagtacagcaaggtcctg
gccctgtacaaccagcataacccgggcgcctcggcggcgccgtgctgcgtgccgcaggcg
ctggagccgctgcccatcgtgtactacgtgggccgcaagcccaaggtggagcagctgtcc
aacatgatcgtgcgctcctgcaagtgcagctga

DBGET integrated database retrieval system