| | PATHWAY: ko01040 | |
Entry |
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Name |
Biosynthesis of unsaturated fatty acids |
Class |
Metabolism; Lipid metabolism
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Pathway map |
ko01040 | Biosynthesis of unsaturated fatty acids |
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Module |
M00415 | Fatty acid elongation in endoplasmic reticulum [PATH:ko01040] |
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Orthology |
K22769 | NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-] |
K22770 | stearoyl-CoA 9-desaturase NADPH oxidoreductase |
K23006 | omega-3 fatty acid desaturase (Delta-15 desaturase) [EC:1.14.19.-] |
K22993 | bifunctional Delta-12/omega-3 fatty acid desaturase [EC:1.14.19.6 1.14.19.-] |
K12405 | (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119] |
K10805 | acyl-CoA thioesterase II [EC:3.1.2.-] |
K10806 | acyl-CoA thioesterase YciA [EC:3.1.2.-] |
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Compound |
C01203 | Oleoyl-[acyl-carrier protein] |
C03242 | Dihomo-gamma-linolenate |
C03595 | 8,11,14-Eicosatrienoyl-CoA |
C04088 | Octadecanoyl-[acyl-carrier protein] |
C06426 | (6Z,9Z,12Z)-Octadecatrienoic acid |
C06427 | (9Z,12Z,15Z)-Octadecatrienoic acid |
C06428 | (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid |
C06429 | (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid |
C08323 | (15Z)-Tetracosenoic acid |
C16160 | Linoleoyl-[acyl-carrier protein] |
C16162 | (9Z,12Z,15Z)-Octadecatrienoyl-CoA |
C16163 | (6Z,9Z,12Z,15Z)-Octadecatetraenoyl-CoA |
C16164 | (8Z,11Z,14Z,17Z)-Icosatetraenoyl-CoA |
C16165 | (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoyl-CoA |
C16166 | (7Z,10Z,13Z,16Z,19Z)-Docosapentaenoyl-CoA |
C16167 | (9Z,12Z,15Z,18Z,21Z)-Tetracosapentaenoyl-CoA |
C16168 | (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA |
C16169 | (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoyl-CoA |
C16170 | (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA |
C16171 | (9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA |
C16172 | (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA |
C16173 | (4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA |
C16179 | (11Z,14Z,17Z)-Icosatrienoyl-CoA |
C16180 | (11Z,14Z)-Icosadienoyl-CoA |
C16513 | (7Z,10Z,13Z,16Z,19Z)-Docosapentaenoic acid |
C16533 | (13Z,16Z)-Docosadienoic acid |
C16645 | (13Z,16Z)-Docosadienoyl-CoA |
C21935 | (6Z,9Z)-Octadecadienoyl-CoA |
C21937 | (8Z,11Z)-Icosadienoyl-CoA |
C21939 | (5Z,8Z,11Z)-Icosatrienoyl-CoA |
C21941 | (7Z,10Z,13Z)-Docosatrienoyl-CoA |
C21949 | (11Z,14Z,17Z,20Z,23Z)-Hexacosapentaenoyl-CoA |
C21951 | (13Z,16Z,19Z,22Z,25Z)-Octacosapentaenoyl-CoA |
C21953 | (8Z,11Z,14Z,17Z,20Z,23Z)-Hexacosahexaenoyl-CoA |
C21959 | (10Z,13Z,16Z,19Z,22Z,25Z)-Octacosahexaenoyl-CoA |
C21961 | (11Z,14Z,17Z,20Z)-Hexacosatetraenoyl-CoA |
C21963 | (13Z,16Z,19Z,22Z)-Octacosatetraenoyl-CoA |
C21965 | (8Z,11Z,14Z,17Z,20Z)-Hexacosapentaenoyl-CoA |
C21967 | (10Z,13Z,16Z,19Z,22Z)-Octacosapentaenoyl-CoA |
C21981 | (6Z,9Z)-Hexadecadienoyl-CoA |
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Reference |
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Authors |
Jakobsson A, Westerberg R, Jacobsson A. |
Title |
Fatty acid elongases in mammals: their regulation and roles in metabolism. |
Journal |
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Reference |
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Authors |
Moon YA, Horton JD. |
Title |
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. |
Journal |
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Reference |
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Authors |
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM. |
Title |
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. |
Journal |
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Reference |
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Authors |
Su HM, Moser AB, Moser HW, Watkins PA. |
Title |
Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. |
Journal |
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Reference |
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Authors |
Huyghe S, Mannaerts GP, Baes M, Van Veldhoven PP. |
Title |
Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model. |
Journal |
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Reference |
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Authors |
Denic V, Weissman JS |
Title |
A molecular caliper mechanism for determining very long-chain fatty acid length. |
Journal |
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Reference |
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Authors |
Ichi I, Kono N, Arita Y, Haga S, Arisawa K, Yamano M, Nagase M, Fujiwara Y, Arai H |
Title |
Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency. |
Journal |
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Reference |
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Authors |
Guillou H, Zadravec D, Martin PG, Jacobsson A |
Title |
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. |
Journal |
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Reference |
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Authors |
Yu M, Benham A, Logan S, Brush RS, Mandal MN, Anderson RE, Agbaga MP |
Title |
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3. |
Journal |
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Reference |
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Authors |
Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A |
Title |
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. |
Journal |
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Reference |
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Authors |
Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A |
Title |
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. |
Journal |
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Reference |
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Authors |
Naganuma T, Sato Y, Sassa T, Ohno Y, Kihara A |
Title |
Biochemical characterization of the very long-chain fatty acid elongase ELOVL7. |
Journal |
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Reference |
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Authors |
Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H |
Title |
Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. |
Journal |
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Reference |
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Authors |
Uemura H |
Title |
Synthesis and production of unsaturated and polyunsaturated fatty acids in yeast: current state and perspectives. |
Journal |
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Reference |
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Authors |
Ferdinandusse S, Denis S, Mooijer PA, Zhang Z, Reddy JK, Spector AA, Wanders RJ |
Title |
Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. |
Journal |
J Lipid Res 42:1987-95 (2001) |
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