KEGG   PATHWAY: ko03260
Entry
ko03260                     Pathway                                
Name
Virion - Human immunodeficiency virus
Class
Genetic Information Processing; Information processing in viruses
Pathway map
ko03260  Virion - Human immunodeficiency virus
ko03260

Drug
D00353  Lamivudine (JAN/USP/INN)
D00413  Zidovudine (JP18/USP/INN)
D00427  Ritonavir (JAN/USP/INN)
D00429  Saquinavir (JAN/USP/INN)
D00435  Nevirapine (JAN/USP/INN)
D00891  Abacavir sulfate (JAN/USP)
D03656  Darunavir (USAN/INN)
D10707  Fostemsavir (USAN)
D10708  Fostemsavir tromethamine (USAN)
D10734  Temsavir (USAN/INN)
D12162  Lenacapavir sodium (JAN/USAN)
D12523  Fipravirimat (USAN/INN)
D12535  Fipravirimat mesylate (USAN)
D12626  Zinlirvimab (USAN/INN)
D12630  Teropavimab (USAN/INN)
D12637  Darunavir hydrate
D12752  Darunavir propylene glycolate
D12944  Zegruvirimat (USAN/INN)
D12945  Zegruvirimat tosylate (USAN)
D13018  Elsulfavirine (INN)
D13020  Labuvirtide (INN)
Other DBs
PDB: 3J3Q 1HIW 3H47 1A1T 1EX4 1HYS 4NCO
Orthology
K04180  CCR5, CD195; C-C chemokine receptor type 5
K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
K06454  CD4; T-cell surface glycoprotein CD4
K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
K19258  tat; HIV protein Tat
K22202  vpr; HIV virus protein R
K22599  PR; HIV protease [EC:3.4.23.16 3.4.23.47]
K22890  vpu; HIV-1 protein Vpu
K22891  nef; HIV protein Nef
K22892  vif; HIV virion infectivity factor
K22951  gag, gag-pol; HIV Gag or Gag-Pol polyprotein
K24266  gp120; HIV envelope glycoprotein gp120
K24801  gp41; HIV transmembrane fusion protein gp41
K24802  RT; HIV-1 reverse transcriptase / ribonuclease H
K24803  IN; HIV-1 integrase
K25306  CA; HIV capsid protein
K25664  NC; HIV-1 nucleocapsid protein
K25665  rev; HIV protein Rev
K25666  MA; HIV-1 matrix protein
K25997  vpx; HIV-2 protein Vpx
Compound
C00925  Heparan sulfate
Reference
  Authors
Zhao G, Perilla JR, Yufenyuy EL, Meng X, Chen B, Ning J, Ahn J, Gronenborn AM, Schulten K, Aiken C, Zhang P
  Title
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
  Journal
Nature 497:643-6 (2013)
DOI:10.1038/nature12162
Reference
PMID:8610175
  Authors
Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI
  Title
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
  Journal
Proc Natl Acad Sci U S A 93:3099-104 (1996)
DOI:10.1073/pnas.93.7.3099
Reference
  Authors
Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M
  Title
X-ray structures of the hexameric building block of the HIV capsid.
  Journal
Cell 137:1282-92 (2009)
DOI:10.1016/j.cell.2009.04.063
Reference
  Authors
Chen JC, Krucinski J, Miercke LJ, Finer-Moore JS, Tang AH, Leavitt AD, Stroud RM
  Title
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
  Journal
Proc Natl Acad Sci U S A 97:8233-8 (2000)
DOI:10.1073/pnas.150220297
Reference
  Authors
Sarafianos SG, Das K, Tantillo C, Clark AD Jr, Ding J, Whitcomb JM, Boyer PL, Hughes SH, Arnold E
  Title
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
  Journal
EMBO J 20:1449-61 (2001)
DOI:10.1093/emboj/20.6.1449
Reference
  Authors
Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA
  Title
Crystal structure of a soluble cleaved HIV-1 envelope trimer.
  Journal
Science 342:1477-83 (2013)
DOI:10.1126/science.1245625
Related
pathway
ko03250  Viral life cycle - HIV-1
ko05170  Human immunodeficiency virus 1 infection

DBGET integrated database retrieval system