KEGG   ORTHOLOGY: K06563
Entry
K06563                      KO                                     
Symbol
CLEC4L_M, DC-SIGN, CD209, CD299
Name
C-type lectin domain family 4 member L/M
Pathway
map03260  Virion - Human immunodeficiency virus
map03264  Virion - Flavivirus
map03265  Virion - Ebolavirus, Lyssavirus and Morbillivirus
map04145  Phagosome
map04625  C-type lectin receptor signaling pathway
map05152  Tuberculosis
map05162  Measles
Disease
H00342  Tuberculosis
H01563  HIV infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03260 Virion - Human immunodeficiency virus
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
   03264 Virion - Flavivirus
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
   03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
   04090 CD molecules
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
   04091 Lectins
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   C-lectin receptors
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
Pattern recognition receptors [BR:ko04054]
 Membrane-bound pattern recognition receptors
  C-type lectin receptors
   K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
CD molecules [BR:ko04090]
 Proteins
  K06563  CD209; CD209 antigen
  K06563  CD299, CLEC4M; CD209 antigen-like
Lectins [BR:ko04091]
 C-Type lectins
  Group 2: Type II membrane receptors (Asialoglycprotien and DC receptors)
   DC-SIGN subgroup
    K06563  CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
Genes
HSA: 10332(CLEC4M) 30835(CD209)
PTR: 450160(CD209) 455661(CLEC4M) 742818(CD209L2)
PPS: 100978434 100990567(CD209) 117976986
GGO: 101151081(CD209) 101152880
PON: 100460339 100460708 112130103
PPYG: 129020370 129020371 129020766
NLE: 100584814 100604872 100605870
HMH: 116478367 116478369 116479423
SSYN: 129461243(CD209) 129461245(CLEC4M) 129461247
MCC: 574211(CD209) 574373(CD209L2)
CSAB: 103233813(CD209)
CANG: 105512914 105512917(CD209)
CJC: 100386005 100410070(CD209)
SBQ: 101034477
CSYR: 103257925
PCOQ: 105807760
MMU: 170776(Cd209c) 170779(Cd209d) 170780(Cd209e) 170786(Cd209a) 69142(Cd209f) 69165(Cd209b) 70192(Cd209g)
RNO: 100363064(Cd209fl1) 288375(Cd209a) 288378(Clec4m) 288386(Cd209cl2) 304197(Cd209l1) 363856(Cd209d) 501797(Cd209e) 688750(Cd209f) 688858(Cd209al3) 688951(Cd209c)
HGL: 101700634
OCU: 100338696
TUP: 102477761(CD209)
GVR: 103596401(CD209)
CFA: 485000(CD209)
CLUD: 112666423
VVP: 112909736
VLG: 121494277(CD209)
NPO: 129521879
AML: 100468094(CD209)
UMR: 103681734(CD209)
UAH: 113242920(CD209)
UAR: 123777585(CD209)
ELK: 111161768
LLV: 125085754
MPUF: 101691569(CD209)
MNP: 132009677(CD209)
MLK: 131823434(CD209)
NVS: 122910789
ORO: 101383340(CD209)
EJU: 114200839(CD209)
ZCA: 113917369(CD209)
MLX: 118005339
NSU: 110593796
LWW: 102743181
FCA: 100462978(CD209)
PYU: 121013902
PCOO: 112852678(CD209)
PBG: 122488624(CD209)
PVIV: 125148699(CD209)
LRUF: 124524505
PTG: 102965531(CD209)
PPAD: 109254195(CD209)
PUC: 125928971
AJU: 106970819
HHV: 120244852(CD209)
BTA: 513266(CD209)
BOM: 102281680(CD209)
BIU: 109561650
BBUB: 102407597(CD209)
BBIS: 104979767(CD209)
CHX: 102172254(CD209)
OAS: 101102057
BTAX: 128051168
ODA: 120863899(CD209)
CCAD: 122439296(CD209)
MBEZ: 129558416
SSC: 100170134(CD209)
CFR: 102508092(CD209)
CBAI: 105078283
CDK: 105087570
VPC: 102525786(CD209)
BACU: 103012833(CD209)
BMUS: 118892886(CD209)
LVE: 103080868
OOR: 101288338(CD209)
DLE: 111166178(CD209)
PCAD: 102993603(CD209)
PSIU: 116750617(CD209)
NASI: 112400240(CD209)
ECB: 100066738 100629660(CD209)
EAI: 106844506 106844507(CD209)
MYB: 102246139(CD209)
MYD: 102758857(CD209)
MMYO: 118659194
MLF: 102431941(CD209)
MDT: 132234658
PKL: 118726017
EFUS: 103295024(CD209)
MNA: 107529879
DRO: 112304984(CD209)
SHON: 118994047(CD209)
PDIC: 114515317
PHAS: 123826568
PPAM: 129078581(CD209)
RFQ: 117037980
PVP: 105307726(CD209) 105307727
RAY: 107519898
MJV: 108402760(CD209)
LAV: 100672381(CD209) 100672671
TMU: 105756391
ETF: 101662740
DNM: 101437275 101437713(CD209)
MDO: 100026844(CD209) 100026862
GAS: 123232296(CD209) 123256820
SHR: 100927143(CD209)
AFZ: 127545319
PCW: 110202118
TVP: 118833865
GGA: 396477
CJO: 107307704
APLA: 101805199
ACYG: 106049482
CATA: 118261076
AFUL: 116500056
SCAN: 115484528
PMOA: 120503678
OTC: 121337880
PRUF: 121358174
GFR: 102034653
OMA: 130263080
PHI: 102112151
SVG: 106863005
FPG: 101924769
FCH: 102045844
CCRI: 104159931
NNT: 104402868
SHAB: 115603406
ACUN: 113490923
TALA: 104364152
HALD: 104323931
HLE: 104832586
AGEN: 126043186
GCL: 127028706
LDI: 104353873
AVIT: 104271698
NNI: 104018398
PCRI: 104038680
PCAO: 104050040
PADL: 103922986
AFOR: 103901564
FGA: 104076256
GSTE: 104256257
CLV: 102088157
PLET: 104625293
EHS: 104508923
CUCA: 104063254
TEO: 104378678
BREG: 104642934
OHA: 104335143
ACAR: 104522117
CPEA: 104394791
CVF: 104296008
RTD: 128901433
AAM: 106500198
AROW: 112976965
NPD: 112954882
DNE: 112992095
SCAM: 104153907
ASN: 102368607
AMJ: 102562601(FBXL12)
CPOO: 109324662
GGN: 109295167
PSS: 102445290
CMY: 102945200
DCC: 119845700
TST: 117888586
ACS: 107982279
TSR: 106547258
GJA: 107124314
STOW: 125427943
NPR: 108801128
BBUF: 120986365
GSH: 117358200
SRX: 107714123
SANH: 107703688
CCAR: 109067796
SMEO: 124381220
TRN: 134321554
EEE: 113590179
CHAR: 116218476
TRU: 105419697
TBEN: 117482016
PGEO: 117448208
PFLV: 114572880
AFB: 129095645
CLUM: 117735721
PSWI: 130190040
MSAM: 119899327
SCHU: 122880661
XMA: 111608715
PRET: 103472223
PFOR: 103137503
PLAI: 106945777
CTUL: 119786992
PPLT: 128433330
SBIA: 133506621
PEE: 133404029
PTAO: 133476500
OTW: 112236038
ONE: 115118917
SALP: 111961126
ELS: 105029019
CMK: 103189102
RTP: 109933327
LERI: 129693977
LPIC: 129282391
AAG: 5575000
SOY: 115879270
DMK: 116920895
PCLA: 123771922
ESN: 126993439
HAZT: 108672021
CBR: CBG_26944
GAE: 121388146
ATEN: 116297122
SPIS: 111319015
 » show all
Reference
PMID:1518869
  Authors
Curtis BM, Scharnowske S, Watson AJ
  Title
Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.
  Journal
Proc Natl Acad Sci U S A 89:8356-60 (1992)
DOI:10.1073/pnas.89.17.8356
  Sequence
[hsa:30835]
Reference
  Authors
Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S
  Title
Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.
  Journal
Gene 228:161-7 (1999)
DOI:10.1016/S0378-1119(99)00004-9
  Sequence
[hsa:10332]
Reference
  Authors
Zhou T, Chen Y, Hao L, Zhang Y
  Title
DC-SIGN and immunoregulation.
  Journal
Cell Mol Immunol 3:279-83 (2006)
Reference
  Authors
Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y
  Title
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
  Journal
Cell 100:587-97 (2000)
DOI:10.1016/S0092-8674(00)80694-7
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