KEGG   PATHWAY: ko03250
Entry
ko03250                     Pathway                                
Name
Viral life cycle - HIV-1
Class
Genetic Information Processing; Information processing in viruses
Pathway map
ko03250  Viral life cycle - HIV-1
ko03250

Drug
D00296  Didanosine (JAN/USP/INN)
D00353  Lamivudine (JAN/USP/INN)
D00412  Zalcitabine (JAN/USP/INN)
D00413  Zidovudine (JP18/USP/INN)
D00427  Ritonavir (JAN/USP/INN)
D00429  Saquinavir (JAN/USP/INN)
D00435  Nevirapine (JAN/USP/INN)
D00445  Stavudine (USAN/INN)
D00891  Abacavir sulfate (JAN/USP)
D00894  Amprenavir (JAN/USAN/INN)
D00895  Delavirdine mesylate (USAN)
D00896  Efavirenz (JAN/USP/INN)
D00897  Indinavir sulfate (USP)
D00899  Nelfinavir mesylate (USAN/INN)
D01055  Emivirine (USAN/INN)
D01160  Saquinavir mesylate (USP)
D01199  Emtricitabine (JAN/USAN/INN)
D01276  Atazanavir sulfate (JAN/USAN)
D01425  Lopinavir (JAN/USP/INN)
D01982  Tenofovir disoproxil fumarate (JAN/USAN)
D02297  Emtricitabine and tenofovir disoproxil
D02497  Fosamprenavir (INN)
D02498  Lopinavir and ritonavir
D02499  Enfuvirtide (USAN/INN)
D02734  Abacavir succinate (USAN)
D02830  Alovudine (USAN/INN)
D02861  Indinavir sulfate ethanolate (JAN)
D02867  Fosamprenavir calcium hydrate (JAN)
D02890  Amdoxovir (USAN/INN)
D03001  Atevirdine mesylate (USAN)
D03253  Brecanavir (USAN)
D03371  Capravirine (USAN/INN)
D03656  Darunavir (USAN/INN)
D03835  Fosamprenavir calcium (USAN)
D03837  Fosamprenavir sodium (USAN)
D03839  Droxinavir hydrochloride (USAN)
D03840  Palinavir (USAN/INN)
D03842  Telinavir (USAN/INN)
D03843  Tipranavir disodium (USAN)
D03981  Elvucitabine (USAN/INN)
D04112  Etravirine (JAN/USAN/INN)
D04757  Lobucavir (USAN/INN)
D04759  Lodenosine (USAN)
D04786  Loviride (USAN/INN)
D05538  Mozenavir (INN)
D05695  Raluridine (USAN)
D06074  Tenofovir (USAN)
D06207  Trecovirsen sodium (USAN)
D06478  Darunavir ethanolate (JAN)
D06564  Bevirimat dimeglumine (USAN)
D06580  Dexelvucitabine (USAN/INN)
D06676  Raltegravir (INN)
D06677  Elvitegravir (JAN/USAN)
D07057  Abacavir (INN)
D07133  Raltegravir potassium (JAN/USAN)
D07471  Atazanavir (INN)
D07507  Zidovudine and lamivudine
D07782  Delavirdine (INN)
D08259  Nelfinavir (INN)
D08605  Tipranavir (INN)
D08775  Abacavir sulfate and lamivudine
D09634  Lersivirine (USAN/INN)
D09720  Rilpivirine (JAN/USAN/INN)
D09906  Fosdevirine (USAN/INN)
D09958  Rilpivirine hydrochloride (JAN/USAN)
D10066  Dolutegravir (USAN)
D10113  Dolutegravir sodium (JAN/USAN)
D10548  Cabotegravir (JAN/USAN/INN)
D10549  Cabotegravir sodium (JAN/USAN)
D10550  Censavudine (USAN)
D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
D10600  Dolutegravir, abacavir and lamivudine
D10624  Doravirine (JAN/USAN/INN)
D10707  Fostemsavir (USAN)
D10708  Fostemsavir tromethamine (USAN)
D10734  Temsavir (USAN/INN)
D10745  Ombitasvir, paritaprevir and ritonavir
D10753  Atazanavir and cobicistat
D10754  Lamivudine and raltegravir
D10755  Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide
D10756  Elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil
D10832  Darunavir and cobicistat
D10834  Tenofovir disoproxil phosphate
D10835  Emtricitabine and tenofovir alafenamide
D10838  Abacavir, lamivudine and zidovudine
D10851  Efavirenz, emtricitabine and tenofovir disoproxil
D10909  Bictegravir (USAN/INN)
D10910  Bictegravir sodium (JAN/USAN)
D11039  Bictegravir, emtricitabine and tenofovir alafenamide
D11246  Dapivirine (USAN/INN)
D11282  Dolutegravir sodium and rilpivirine hydrochloride
D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
D11391  Tenofovir disoproxil maleate
D11392  Efavirenz, lamivudine and tenofovir disoproxil fumarate
D11395  Lamivudine and tenofovir disoproxil
D11396  Doravirine, lamivudine and tenofovir disoproxil
D11432  Islatravir (USAN)
D11521  Lamivudine, nevirapine and zidovudine
D11522  Dolutegravir and lamivudine
D11721  Rovafovir etalafenamide (USAN)
D11722  Rovafovir etalafenamide citrate (USAN)
D11914  Islatravir hydrate (JAN/USAN)
D11966  Cabotegravir and rilpivirine
D12161  Lenacapavir (USAN/INN)
D12162  Lenacapavir sodium (JAN/USAN)
D12288  Ulonivirine (USAN)
D12523  Fipravirimat (USAN/INN)
D12535  Fipravirimat mesylate (USAN)
D12626  Zinlirvimab (USAN/INN)
D12630  Teropavimab (USAN/INN)
D12637  Darunavir hydrate
D12752  Darunavir propylene glycolate
D12944  Zegruvirimat (USAN/INN)
D12945  Zegruvirimat tosylate (USAN)
D13018  Elsulfavirine (INN)
D13020  Labuvirtide (INN)
D13189  Alimatravir (USAN)
Orthology
K01349  FURIN, PCSK3; furin [EC:3.4.21.75]
K02211  CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
K03767  PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
K04180  CCR5, CD195; C-C chemokine receptor type 5
K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
K06454  CD4; T-cell surface glycoprotein CD4
K06731  BST2, CD317; bone marrow stromal cell antigen 2
K07936  RAN; GTP-binding nuclear protein Ran
K09578  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
K10429  MAP1; microtubule-associated protein 1
K10648  TRIM5; tripartite motif-containing protein 5 [EC:2.3.2.27]
K11648  SMARCB1, SNF5, INI1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
K12182  HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate
K12183  TSG101, STP22, VPS23; ESCRT-I complex subunit TSG101
K12194  CHMP4A_B, SNF7, VPS32A_B; charged multivesicular body protein 4A/B
K12195  CHMP6, VPS20; charged multivesicular body protein 6
K12196  VPS4; vacuolar protein-sorting-associated protein 4
K12200  PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein
K14290  XPO1, CRM1; exportin-1
K14296  NUP153; nuclear pore complex protein Nup153
K14398  CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7
K14754  MX; interferon-induced GTP-binding protein Mx
K15171  SUPT4H1, SPT4; transcription elongation factor SPT4
K15172  SUPT5H, SPT5; transcription elongation factor SPT5
K15179  WHSC2, NELFA; negative elongation factor A
K15180  COBRA1, NELFB; negative elongation factor B
K15181  TH1L, NELFD; negative elongation factor C/D
K15182  RDBP, NELFE; negative elongation factor E
K15183  ELL; RNA polymerase II elongation factor ELL
K15185  AFF4; AF4/FMR2 family member 4
K15187  MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3
K15188  CCNT; cyclin T
K15436  TRPO3, MTR10; transportin-3
K18739  BICD; protein bicaudal D
K18750  APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]
K19258  tat; HIV protein Tat
K19287  env, gp160; HIV envelope glycoprotein gp160
K22202  vpr; HIV virus protein R
K22544  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
K22599  PR; HIV protease [EC:3.4.23.16 3.4.23.47]
K22890  vpu; HIV-1 protein Vpu
K22891  nef; HIV protein Nef
K22892  vif; HIV virion infectivity factor
K22951  gag, gag-pol; HIV Gag or Gag-Pol polyprotein
K24266  gp120; HIV envelope glycoprotein gp120
K24801  gp41; HIV transmembrane fusion protein gp41
K24802  RT; HIV-1 reverse transcriptase / ribonuclease H
K24803  IN; HIV-1 integrase
K25057  PSIP1, LEDGF; PC4 and SFRS1-interacting protein
K25306  CA; HIV capsid protein
K25655  SERINC5; serine incorporator 5
K25661  SERINC3; serine incorporator 3
K25663  FEZ1; fasciculation and elongation protein zeta-1
K25664  NC; HIV-1 nucleocapsid protein
K25665  rev; HIV protein Rev
K25666  MA; HIV-1 matrix protein
K25667  p6gag; HIV-1 p6-gag
K27688  MDFIC; MyoD family inhibitor domain-containing protein
Reference
PMID:27357278
  Authors
Li G, De Clercq E
  Title
HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.
  Journal
Microbiol Mol Biol Rev 80:679-731 (2016)
DOI:10.1128/MMBR.00065-15
Reference
PMID:21284899
  Authors
Tagliamonte M, Tornesello ML, Buonaguro FM, Buonaguro L
  Title
Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.
  Journal
J Transl Med 9 Suppl 1:S1 (2011)
DOI:10.1186/1479-5876-9-S1-S1
Reference
PMID:31028522
  Authors
Novikova M, Zhang Y, Freed EO, Peng K
  Title
Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle.
  Journal
Virol Sin 34:119-134 (2019)
DOI:10.1007/s12250-019-00095-3
Reference
PMID:30286189
  Authors
Rawle DJ, Harrich D
  Title
Toward the "unravelling" of HIV: Host cell factors involved in HIV-1 core uncoating.
  Journal
PLoS Pathog 14:e1007270 (2018)
DOI:10.1371/journal.ppat.1007270
Reference
PMID:25036886
  Authors
Le Sage V, Mouland AJ, Valiente-Echeverria F
  Title
Roles of HIV-1 capsid in viral replication and immune evasion.
  Journal
Virus Res 193:116-29 (2014)
DOI:10.1016/j.virusres.2014.07.010
Reference
PMID:32429351
  Authors
Murphy RE, Saad JS
  Title
The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation.
  Journal
Viruses 12:548 (2020)
DOI:10.3390/v12050548
Reference
PMID:21360054
  Authors
He N, Zhou Q
  Title
New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
  Journal
J Neuroimmune Pharmacol 6:260-8 (2011)
DOI:10.1007/s11481-011-9267-6
Reference
PMID:19865606
  Authors
Pincetic A, Leis J
  Title
The Mechanism of Budding of Retroviruses From Cell Membranes.
  Journal
Adv Virol 2009:6239691-6239699 (2009)
DOI:10.1155/2009/623969
Reference
PMID:32858867
  Authors
Kleinpeter AB, Freed EO
  Title
HIV-1 Maturation: Lessons Learned from Inhibitors.
  Journal
Viruses 12:940 (2020)
DOI:10.3390/v12090940
Reference
PMID:12944466
  Authors
Young TM, Wang Q, Pe'ery T, Mathews MB
  Title
The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.
  Journal
Mol Cell Biol 23:6373-84 (2003)
DOI:10.1128/MCB.23.18.6373-6384.2003
Related
pathway
ko03013  Nucleocytoplasmic transport
ko03230  Viral genome structure
ko04144  Endocytosis

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