KEGG   PATHWAY: ko03250
Entry
ko03250                     Pathway                                
Name
Viral life cycle - HIV-1
Class
Genetic Information Processing; Information processing in viruses
Pathway map
ko03250  Viral life cycle - HIV-1
ko03250

Drug
D00296  Didanosine (JAN/USP/INN)
D00353  Lamivudine (JAN/USP/INN)
D00412  Zalcitabine (JAN/USP/INN)
D00413  Zidovudine (JP18/USP/INN)
D00427  Ritonavir (JAN/USP/INN)
D00429  Saquinavir (JAN/USP/INN)
D00435  Nevirapine (JAN/USP/INN)
D00445  Stavudine (USAN/INN)
D00891  Abacavir sulfate (JAN/USP)
D00894  Amprenavir (JAN/USAN/INN)
D00895  Delavirdine mesylate (USAN)
D00896  Efavirenz (JAN/USP/INN)
D00897  Indinavir sulfate (USP)
D00899  Nelfinavir mesylate (USAN/INN)
D01055  Emivirine (USAN/INN)
D01160  Saquinavir mesylate (USP)
D01199  Emtricitabine (JAN/USAN/INN)
D01276  Atazanavir sulfate (JAN/USAN)
D01425  Lopinavir (JAN/USP/INN)
D01982  Tenofovir disoproxil fumarate (JAN/USAN)
D02297  Emtricitabine and tenofovir disoproxil
D02497  Fosamprenavir (INN)
D02498  Lopinavir and ritonavir
D02499  Enfuvirtide (USAN/INN)
D02734  Abacavir succinate (USAN)
D02830  Alovudine (USAN/INN)
D02861  Indinavir sulfate ethanolate (JAN)
D02867  Fosamprenavir calcium hydrate (JAN)
D02890  Amdoxovir (USAN/INN)
D03001  Atevirdine mesylate (USAN)
D03253  Brecanavir (USAN)
D03371  Capravirine (USAN/INN)
D03656  Darunavir (USAN/INN)
D03835  Fosamprenavir calcium (USAN)
D03837  Fosamprenavir sodium (USAN)
D03839  Droxinavir hydrochloride (USAN)
D03840  Palinavir (USAN/INN)
D03842  Telinavir (USAN/INN)
D03843  Tipranavir disodium (USAN)
D03981  Elvucitabine (USAN/INN)
D04112  Etravirine (JAN/USAN/INN)
D04757  Lobucavir (USAN/INN)
D04759  Lodenosine (USAN)
D04786  Loviride (USAN/INN)
D05538  Mozenavir (INN)
D05695  Raluridine (USAN)
D06074  Tenofovir (USAN)
D06207  Trecovirsen sodium (USAN)
D06478  Darunavir ethanolate (JAN)
D06564  Bevirimat dimeglumine (USAN)
D06580  Dexelvucitabine (USAN/INN)
D06676  Raltegravir (INN)
D06677  Elvitegravir (JAN/USAN)
D07057  Abacavir (INN)
D07133  Raltegravir potassium (JAN/USAN)
D07471  Atazanavir (INN)
D07507  Zidovudine and lamivudine
D07782  Delavirdine (INN)
D08259  Nelfinavir (INN)
D08605  Tipranavir (INN)
D08775  Abacavir sulfate and lamivudine
D09634  Lersivirine (USAN/INN)
D09720  Rilpivirine (JAN/USAN/INN)
D09906  Fosdevirine (USAN/INN)
D09958  Rilpivirine hydrochloride (JAN/USAN)
D10066  Dolutegravir (USAN)
D10113  Dolutegravir sodium (JAN/USAN)
D10548  Cabotegravir (JAN/USAN/INN)
D10549  Cabotegravir sodium (JAN/USAN)
D10550  Censavudine (USAN)
D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
D10600  Dolutegravir, abacavir and lamivudine
D10624  Doravirine (JAN/USAN/INN)
D10707  Fostemsavir (USAN)
D10708  Fostemsavir tromethamine (USAN)
D10734  Temsavir (USAN/INN)
D10745  Ombitasvir, paritaprevir and ritonavir
D10753  Atazanavir and cobicistat
D10754  Lamivudine and raltegravir
D10755  Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide
D10756  Elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil
D10832  Darunavir and cobicistat
D10834  Tenofovir disoproxil phosphate
D10835  Emtricitabine and tenofovir alafenamide
D10838  Abacavir, lamivudine and zidovudine
D10851  Efavirenz, emtricitabine and tenofovir disoproxil
D10909  Bictegravir (USAN/INN)
D10910  Bictegravir sodium (JAN/USAN)
D11039  Bictegravir, emtricitabine and tenofovir alafenamide
D11246  Dapivirine (USAN/INN)
D11282  Dolutegravir sodium and rilpivirine hydrochloride
D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
D11391  Tenofovir disoproxil maleate
D11392  Efavirenz, lamivudine and tenofovir disoproxil fumarate
D11395  Lamivudine and tenofovir disoproxil
D11396  Doravirine, lamivudine and tenofovir disoproxil
D11432  Islatravir (USAN)
D11521  Lamivudine, nevirapine and zidovudine
D11522  Dolutegravir and lamivudine
D11721  Rovafovir etalafenamide (USAN)
D11722  Rovafovir etalafenamide citrate (USAN)
D11914  Islatravir hydrate (JAN/USAN)
D11966  Cabotegravir and rilpivirine
D12161  Lenacapavir (USAN/INN)
D12162  Lenacapavir sodium (JAN/USAN)
D12288  Ulonivirine (USAN)
D12523  Fipravirimat (USAN/INN)
D12535  Fipravirimat mesylate (USAN)
D12626  Zinlirvimab (USAN/INN)
D12630  Teropavimab (USAN/INN)
D12637  Darunavir hydrate
D12752  Darunavir propylene glycolate
Orthology
K24801  HIV transmembrane fusion protein gp41
K24266  HIV envelope glycoprotein gp120
K04180  C-C chemokine receptor type 5
K04189  C-X-C chemokine receptor type 4
K06454  T-cell surface glycoprotein CD4
K10429  microtubule-associated protein 1
K25663  fasciculation and elongation protein zeta-1
K18739  protein bicaudal D
K10648  tripartite motif-containing protein 5 [EC:2.3.2.27]
K25306  HIV capsid protein
K25664  HIV-1 nucleocapsid protein
K22202  HIV virus protein R
K19258  HIV protein Tat
K22599  HIV protease [EC:3.4.23.16 3.4.23.47]
K24802  HIV-1 reverse transcriptase / ribonuclease H [EC:2.7.7.49 2.7.7.7 3.1.26.13]
K24803  HIV-1 integrase
K22891  HIV protein Nef
K22892  HIV virion infectivity factor
K18750  C->U-editing enzyme APOBEC3 [EC:3.5.4.-]
K22544  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
K25057  PC4 and SFRS1-interacting protein
K09578  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
K11648  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
K03767  peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
K14398  cleavage and polyadenylation specificity factor subunit 6/7
K15436  transportin-3
K14754  interferon-induced GTP-binding protein Mx
K12172  E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
K14296  nuclear pore complex protein Nup153
K04498  E1A/CREB-binding protein [EC:2.3.1.48]
K06062  histone acetyltransferase [EC:2.3.1.48]
K27688  MyoD family inhibitor domain-containing protein
K02211  cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
K15188  cyclin T
K15185  AF4/FMR2 family member 4
K15183  RNA polymerase II elongation factor ELL
K15187  YEATS domain-containing protein 1/3
K15179  negative elongation factor A
K15180  negative elongation factor B
K15181  negative elongation factor C/D
K15182  negative elongation factor E
K15171  transcription elongation factor SPT4
K15172  transcription elongation factor SPT5
K25665  HIV protein Rev
K14290  exportin-1
K07936  GTP-binding nuclear protein Ran
K19287  HIV envelope glycoprotein gp160
K01349  furin [EC:3.4.21.75]
K25661  serine incorporator 3
K25655  serine incorporator 5
K06731  bone marrow stromal cell antigen 2
K22890  HIV-1 protein Vpu
K12182  hepatocyte growth factor-regulated tyrosine kinase substrate
K12183  ESCRT-I complex subunit TSG101
K12195  charged multivesicular body protein 6
K12194  charged multivesicular body protein 4A/B
K12200  programmed cell death 6-interacting protein
K12196  vacuolar protein-sorting-associated protein 4
K22951  HIV Gag or Gag-Pol polyprotein
K25666  HIV-1 matrix protein
K25667  HIV-1 p6-gag
Reference
  Authors
Li G, De Clercq E
  Title
HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.
  Journal
Microbiol Mol Biol Rev 80:679-731 (2016)
DOI:10.1128/MMBR.00065-15
Reference
  Authors
Tagliamonte M, Tornesello ML, Buonaguro FM, Buonaguro L
  Title
Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.
  Journal
J Transl Med 9 Suppl 1:S1 (2011)
DOI:10.1186/1479-5876-9-S1-S1
Reference
  Authors
Novikova M, Zhang Y, Freed EO, Peng K
  Title
Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle.
  Journal
Virol Sin 34:119-134 (2019)
DOI:10.1007/s12250-019-00095-3
Reference
  Authors
Rawle DJ, Harrich D
  Title
Toward the "unravelling" of HIV: Host cell factors involved in HIV-1 core uncoating.
  Journal
PLoS Pathog 14:e1007270 (2018)
DOI:10.1371/journal.ppat.1007270
Reference
  Authors
Le Sage V, Mouland AJ, Valiente-Echeverria F
  Title
Roles of HIV-1 capsid in viral replication and immune evasion.
  Journal
Virus Res 193:116-29 (2014)
DOI:10.1016/j.virusres.2014.07.010
Reference
  Authors
Murphy RE, Saad JS
  Title
The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation.
  Journal
Viruses 12:E548 (2020)
DOI:10.3390/v12050548
Reference
  Authors
He N, Zhou Q
  Title
New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
  Journal
J Neuroimmune Pharmacol 6:260-8 (2011)
DOI:10.1007/s11481-011-9267-6
Reference
  Authors
Pincetic A, Leis J
  Title
The Mechanism of Budding of Retroviruses From Cell Membranes.
  Journal
Adv Virol 2009:6239691-6239699 (2009)
DOI:10.1155/2009/623969
Reference
  Authors
Kleinpeter AB, Freed EO
  Title
HIV-1 Maturation: Lessons Learned from Inhibitors.
  Journal
Viruses 12:E940 (2020)
DOI:10.3390/v12090940
Reference
  Authors
Young TM, Wang Q, Pe'ery T, Mathews MB
  Title
The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.
  Journal
Mol Cell Biol 23:6373-84 (2003)
DOI:10.1128/MCB.23.18.6373-6384.2003
Related
pathway
ko03013  Nucleocytoplasmic transport
ko03230  Viral genome structure
ko04144  Endocytosis
LinkDB

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