KEGG   PATHWAY: kqu00260
Entry
kqu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella quasipneumoniae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kqu00260  Glycine, serine and threonine metabolism
kqu00260

Module
kqu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kqu00260]
kqu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kqu00260]
kqu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kqu00260]
kqu_M00555  Betaine biosynthesis, choline => betaine [PATH:kqu00260]
kqu_M00621  Glycine cleavage system [PATH:kqu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella quasipneumoniae [GN:kqu]
Gene
AVR78_05925  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
AVR78_08210  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AVR78_05030  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
AVR78_17810  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AVR78_02840  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AVR78_08215  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AVR78_08220  threonine synthase [KO:K01733] [EC:4.2.3.1]
AVR78_13335  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
AVR78_23955  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AVR78_14315  bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AVR78_24665  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AVR78_03475  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AVR78_25445  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AVR78_15675  glycerate kinase [KO:K11529] [EC:2.7.1.165]
AVR78_12520  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AVR78_08165  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AVR78_03695  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
AVR78_11850  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AVR78_25025  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AVR78_00600  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AVR78_03140  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AVR78_09635  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AVR78_13500  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
AVR78_08130  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
AVR78_17065  NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AVR78_03720  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AVR78_03715  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AVR78_16375  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
AVR78_00550  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
AVR78_00560  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AVR78_08825  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AVR78_09665  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AVR78_00555  glycine cleavage system protein H [KO:K02437]
AVR78_26185  creatininase [KO:K08688] [EC:3.5.3.3]
AVR78_24120  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
AVR78_11575  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AVR78_11580  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AVR78_00910  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AVR78_00915  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
AVR78_20735  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AVR78_25500  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AVR78_20475  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
AVR78_05205  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AVR78_04310  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
AVR78_00095  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
AVR78_15680  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AVR78_15685  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AVR78_18040  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AVR78_18045  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kqu00010  Glycolysis / Gluconeogenesis
kqu00020  Citrate cycle (TCA cycle)
kqu00230  Purine metabolism
kqu00250  Alanine, aspartate and glutamate metabolism
kqu00270  Cysteine and methionine metabolism
kqu00290  Valine, leucine and isoleucine biosynthesis
kqu00300  Lysine biosynthesis
kqu00330  Arginine and proline metabolism
kqu00460  Cyanoamino acid metabolism
kqu00470  D-Amino acid metabolism
kqu00564  Glycerophospholipid metabolism
kqu00600  Sphingolipid metabolism
kqu00620  Pyruvate metabolism
kqu00630  Glyoxylate and dicarboxylate metabolism
kqu00640  Propanoate metabolism
kqu00680  Methane metabolism
kqu00860  Porphyrin metabolism
kqu00920  Sulfur metabolism
KO pathway
ko00260   
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