KEGG   PATHWAY: mcal00564
Entry
mcal00564                   Pathway                                
Name
Glycerophospholipid metabolism - Mus caroli (Ryukyu mouse)
Class
Metabolism; Lipid metabolism
Pathway map
mcal00564  Glycerophospholipid metabolism
mcal00564

Module
mcal_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:mcal00564]
mcal_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:mcal00564]
mcal_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:mcal00564]
Other DBs
GO: 0006650
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110310422  Gpd1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
110302004  Gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
110289297  Gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
110285261  Gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
110284259  Gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3 [KO:K00629] [EC:2.3.1.15]
110299683  Gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
110295009  Gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
110310160  Agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
110312431  Agpat1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
110302867  Agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
110283831  Agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
110300134  Agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
110283975  Lclat1; lysocardiolipin acyltransferase 1 isoform X2 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
110308057  Mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
110306867  Mboat2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
110299645  Gnpat; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
110305174  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
110307554  Plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
110303185  Plpp2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
110292859  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
110312521  Lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
110290456  Lpin3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
110307500  Lpin1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
110299981  Plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
110298110  Plpp4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
110306666  Dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
110296164  Dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
110294167  Dgkq; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
110287220  Dgkk; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
110306000  Dgke; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
110309269  Dgkh; diacylglycerol kinase eta isoform X3 [KO:K00901] [EC:2.7.1.107]
110304105  Dgka; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
110290773  Dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
110290399  Dgkz; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
110311403  Dgkg; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
110303094  Chpt1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
110291241  Cept1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
110304819  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
110290757  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
110307132  Pld4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
110297422  Pld3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
110299959  Lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
110293160  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110292815  Pla2g5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110292816  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
110303363  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
110295155  Pla2g1b; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110311666  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110306129  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110291110  Pla2g12a; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110293697  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110293705  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110293232  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110289370  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110284581  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
110289583  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110294088  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
110298861  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
110290316  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
110310640  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110294493  Plb1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
110285658  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
110300420  Lpcat2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
110308216  Lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
110295425  lysophosphatidylcholine acyltransferase 2B [KO:K13510] [EC:2.3.1.23 2.3.1.67]
110286533  Lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
110296068  Lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
110290718  Lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
110299831  Pla2g15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
110292582  Lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
110299769  Pnpla6; neuropathy target esterase isoform X3 [KO:K14676] [EC:3.1.1.5]
110289998  Pnpla7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
110312472  Gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
110309681  Chat; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
110294470  Ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
110285382  Chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
110311068  Chkb; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
110305039  Phospho1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
110286653  Pcyt1b; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
110311362  Pcyt1a; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
110294326  Selenoi; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
110298111  Etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
110296386  Etnk1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
110304589  Pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
110291341  Etnppl; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
110305820  Pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
110295340  Cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
110311594  Cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
110311435  Pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
110307589  Ptdss1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
110298796  Ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
110283893  phosphatidylserine decarboxylase proenzyme, mitochondrial-like [KO:K01613] [EC:4.1.1.65]
110293852  Pisd; LOW QUALITY PROTEIN: phosphatidylserine decarboxylase proenzyme, mitochondrial [KO:K01613] [EC:4.1.1.65]
110304363  Pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
110289057  Crls1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
110286591  Taz; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
110310855  Lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
110298650  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
110297594  Mboat7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
mcal00010  Glycolysis / Gluconeogenesis
mcal00260  Glycine, serine and threonine metabolism
mcal00561  Glycerolipid metabolism
mcal00562  Inositol phosphate metabolism
mcal00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
mcal00565  Ether lipid metabolism
mcal00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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