KEGG   PATHWAY: mcc00564
Entry
mcc00564                    Pathway                                
Name
Glycerophospholipid metabolism - Macaca mulatta (rhesus monkey)
Class
Metabolism; Lipid metabolism
Pathway map
mcc00564  Glycerophospholipid metabolism
mcc00564

Module
mcc_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:mcc00564]
mcc_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:mcc00564]
mcc_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:mcc00564]
Other DBs
GO: 0006650
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424557  PLB1; LOW QUALITY PROTEIN: phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100424593  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100426338  PNPLA6; neuropathy target esterase isoform X1 [KO:K14676] [EC:3.1.1.5]
100430900  PLA2G2F; group IIF secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
100533113  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
114669774  [KO:K08730] [EC:2.7.8.29]
114675509  [KO:K00629] [EC:2.3.1.15]
574297  TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
693653  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
693700  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
693742  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
694963  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
695126  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
695518  GDPD5; glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1 [KO:K28873]
695641  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
695947  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
696042  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
696056  CHPT1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
696329  LPIN3; phosphatidate phosphatase LPIN3 isoform X2 [KO:K15728] [EC:3.1.3.4]
696388  LPCAT4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
696414  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
696712  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
696880  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
697192  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
697682  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
697726  PLA2G12A; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
698276  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
698582  [KO:K08730] [EC:2.7.8.29]
698605  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
698959  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X4 [KO:K06124] [EC:3.1.3.75]
699083  PEMT; phosphatidylethanolamine N-methyltransferase isoform X2 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
699337  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
699967  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
700184  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
700683  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
701083  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
701486  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
701760  PCYT1B; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
701872  LCAT; phosphatidylcholine-sterol acyltransferase isoform X2 [KO:K00650] [EC:2.3.1.43]
702619  PLA2G15; group XV phospholipase A2 precursor [KO:K06129] [EC:3.1.1.5]
702700  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
704027  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
704132  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
704299  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
704361  SAMD8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
704395  PLPP5; phospholipid phosphatase 5 isoform X2 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
704483  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
704520  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
704629  PLA2G5; calcium-dependent phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
704735  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
704859  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
706078  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
706539  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
706649  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
707076  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
707141  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
707177  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
707527  PLD4; phospholipase D4 isoform X2 [KO:K16860] [EC:3.1.4.4]
707592  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
707690  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
707723  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
708031  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
709578  DGKI; diacylglycerol kinase iota isoform X15 [KO:K00901] [EC:2.7.1.107]
709753  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
709977  CHAT; choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
710125  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
710144  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
710363  GPAT4; glycerol-3-phosphate acyltransferase 4 isoform X1 [KO:K13506] [EC:2.3.1.15]
710559  DGKA; diacylglycerol kinase alpha isoform X8 [KO:K00901] [EC:2.7.1.107]
710564  CHKA; choline kinase alpha isoform X2 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
711398  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X4 [KO:K13514] [EC:2.3.1.-]
712450  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
712705  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
713198  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
713204  GPAT3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
713301  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
713370  ACHE; acetylcholinesterase precursor [KO:K01049] [EC:3.1.1.7]
713603  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
714210  DGKD; diacylglycerol kinase delta isoform X4 [KO:K00901] [EC:2.7.1.107]
714639  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
715006  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
715254  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
715993  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
716377  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
716635  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
716847  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
716905  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X6 [KO:K01613] [EC:4.1.1.65]
717084  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
717174  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
717517  [KO:K01047] [EC:3.1.1.4]
717991  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
718026  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
718265  CRLS1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
718321  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
718510  [KO:K16342] [EC:3.1.1.4]
719074  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
719117  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
721004  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
721016  [KO:K06128] [EC:3.1.1.5]
721508  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
721573  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
722105  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
722178  PLAAT3; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
722182  PLAAT2; HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
mcc00010  Glycolysis / Gluconeogenesis
mcc00260  Glycine, serine and threonine metabolism
mcc00561  Glycerolipid metabolism
mcc00562  Inositol phosphate metabolism
mcc00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
mcc00565  Ether lipid metabolism
mcc00620  Pyruvate metabolism
KO pathway
ko00564   

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