KEGG   PATHWAY: mcc04612
Entry
mcc04612                    Pathway                                
Name
Antigen processing and presentation - Macaca mulatta (rhesus monkey)
Class
Organismal Systems; Immune system
Pathway map
mcc04612  Antigen processing and presentation
mcc04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100125559  KIR3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 precursor [KO:K07980]
100125560  KIR3DL12; killer-cell Ig-like receptor KIR3DL12 precursor [KO:K07980]
100125563  KIR3DH5; killer-cell Ig-like receptor KIR3DH5 precursor [KO:K07980]
100125567  MAMU-KIR; killer immunoglobulin-like receptor KIR3DH-like 5 precursor [KO:K07980]
100125571  KIR3DS05; killer immunoglobulin-like receptor KIR precursor [KO:K07980]
100125572  [KO:K07980]
100125574  KIR3DL1; LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 3DL1 [KO:K07980]
100125577  KIR3DL11; killer immunoglobulin-like receptor KIR3DL11 precursor [KO:K07980]
100187576  MAMU-AG; major histocompatibility complex, class I, AG precursor [KO:K06751]
100187587  MAMU-DRA; mamu class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
100424037  [KO:K01365] [EC:3.4.22.15]
100424348  [KO:K06751]
100424758  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
100426197  [KO:K06751]
100428228  MAMU-DRB5; LOW QUALITY PROTEIN: MHC class II antigen, Mamu-DRB5 [KO:K06752]
100428435  [KO:K06752]
100429857  MAMU-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
106994859  [KO:K07980]
106995452  [KO:K06751]
106996627  [KO:K06751]
106996676  [KO:K06751]
106997893  [KO:K06751]
106997902  [KO:K06752]
114669735  [KO:K07980]
114669810  [KO:K06752]
114669856  [KO:K03283]
114670012  [KO:K06698]
114670780  KLRC2; NKG2-C type II integral membrane protein [KO:K24233]
114672113  [KO:K08056] [EC:5.3.4.1]
114675357  [KO:K06752]
114676051  [KO:K06751]
114677644  [KO:K06751]
574145  KLRD1; natural killer cells antigen CD94 [KO:K06516]
574146  KLRC1; NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
574271  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
574282  IFNG; interferon gamma precursor [KO:K04687]
692100  MAMU-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]
694372  [KO:K06751]
694441  RFXAP; regulatory factor X-associated protein [KO:K08063]
694569  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
696175  KIR3DL0; killer immunoglobulin-like receptor KIR3DL0 precursor [KO:K07980]
696290  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
696306  [KO:K10785]
697904  [KO:K10785]
698329  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
698785  [KO:K10785]
699243  MAMU-A3; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
699409  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
700451  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
702293  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
703029  [KO:K10785]
703193  HSPA5; 78 kDa glucose-regulated protein precursor [KO:K09490] [EC:3.6.4.10]
703734  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
704794  CANX; calnexin isoform X2 [KO:K08054]
707167  [KO:K01365] [EC:3.4.22.15]
707989  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
708080  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
708431  HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 [KO:K04079]
708717  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
709076  MAMU-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
709412  [KO:K03283]
709585  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
710149  [KO:K10784]
710369  RFX5; DNA-binding protein RFX5 [KO:K08061]
710761  CIITA; MHC class II transactivator isoform X7 [KO:K08060] [EC:2.7.11.1]
710820  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
711029  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
711532  MAMU-E; major histocompatibility complex, class I, E precursor [KO:K06751]
711832  MAMU-A; major histocompatibility complex, class I, A isoform X1 [KO:K06751]
711900  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
712428  B2M; beta-2-microglobulin precursor [KO:K08055]
713807  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
714364  PSME1; proteasome activator complex subunit 1 [KO:K06696]
714964  [KO:K06751]
715288  PSME2; proteasome activator complex subunit 2 [KO:K06697]
715467  TNF; tumor necrosis factor [KO:K03156]
716633  [KO:K03283]
716823  MAMU-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]
716910  CALR; calreticulin precursor [KO:K08057]
717702  MAMU-DOB; major histocompatibility complex, class II, DO beta precursor [KO:K06752]
717726  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
717742  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
717870  MAMU-DMA; major histocompatibility complex, class II, DM alpha precursor [KO:K06752]
717947  MAMU-DOA; major histocompatibility complex, class II, DO alpha precursor [KO:K06752]
717969  MAMU-DPB; major histocompatibility complex, class II, DP beta [KO:K06752]
717992  MAMU-DPA; major histocompatibility complex, class II, DP alpha [KO:K06752]
718235  TAPBP; tapasin precursor [KO:K08058]
719250  [KO:K06751]
719379  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
719697  NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
719702  [KO:K06751]
719706  RFXANK; DNA-binding protein RFXANK [KO:K08062]
720001  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
720054  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
720132  [KO:K06751]
720582  MAMU-DQA1; major histocompatibility complex, class II, DQ alpha 1 precursor [KO:K06752]
722782  KIR2DL4; killer cell immunoglobulin-like receptor 2DL4 precursor [KO:K24231]
722783  KIR3DL21; LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 21 [KO:K07980]
723473  [KO:K06751]
735306  KIR3DH; killer cell immunoglobulin-like receptor, 3 domains, hybrid precursor [KO:K07980]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
mcc03050  Proteasome
mcc04650  Natural killer cell mediated cytotoxicity
mcc04660  T cell receptor signaling pathway
KO pathway
ko04612   

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