KEGG   PATHWAY: mcoc04721
Entry
mcoc04721                   Pathway                                
Name
Synaptic vesicle cycle - Mastomys coucha (southern multimammate mouse)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
mcoc04721  Synaptic vesicle cycle
mcoc04721

Other DBs
GO: 0016079 0048488
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067850  [KO:K04344]
116068099  Cplx1; complexin-1 [KO:K15294]
116068441  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
116068473  Stx2; syntaxin-2 isoform X1 [KO:K08486]
116068522  Stx1a; syntaxin-1A [KO:K04560]
116069414  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
116069489  Rab3a; ras-related protein Rab-3A [KO:K07882]
116069526  Unc13a; protein unc-13 homolog A isoform X1 [KO:K15293]
116069872  Slc6a2; sodium-dependent noradrenaline transporter [KO:K05035]
116070056  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
116070370  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
116071446  Slc18a1; chromaffin granule amine transporter [KO:K08155]
116071975  Cplx3; complexin-3 [KO:K15295]
116072110  Dnm2; dynamin-2 isoform X1 [KO:K23484]
116072609  Unc13c; protein unc-13 homolog C [KO:K15293]
116074659  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
116075838  Syt1; synaptotagmin-1 isoform X1 [KO:K15290]
116075842  Slc17a8; vesicular glutamate transporter 3 [KO:K12302]
116076227  Slc1a6; excitatory amino acid transporter 4 [KO:K05617]
116077943  Atp6v0e1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153]
116078194  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
116078318  Vamp2; vesicle-associated membrane protein 2 [KO:K13504]
116078330  Slc6a4; sodium-dependent serotonin transporter isoform X1 [KO:K05037]
116078714  Ap2b1; AP-2 complex subunit beta [KO:K11825]
116079012  Nsf; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
116079113  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
116079228  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116079860  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
116080061  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
116080803  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
116081555  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
116081640  Cplx2; complexin-2 [KO:K15294]
116082154  Cltb; clathrin light chain B isoform X1 [KO:K04645]
116083177  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
116083755  Slc1a3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
116084473  Slc18a3; vesicular acetylcholine transporter [KO:K14636]
116085721  Ap2m1; AP-2 complex subunit mu [KO:K11826]
116085932  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
116087225  Slc6a7; sodium-dependent proline transporter [KO:K05040]
116087279  Cplx4; complexin-4 [KO:K15295]
116088138  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
116088238  Rims1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
116088998  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
116089786  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116089992  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
116090017  Stxbp1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
116090562  Slc1a2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
116091000  [KO:K08486]
116091007  Snap25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
116091309  Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
116095486  Slc1a7; excitatory amino acid transporter 5 isoform X1 [KO:K05618]
116095885  Unc13b; protein unc-13 homolog B isoform X1 [KO:K15293]
116095922  Clta; clathrin light chain A isoform X1 [KO:K04644]
116096127  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
116096505  Slc6a9; sodium- and chloride-dependent glycine transporter 1 isoform X1 [KO:K05038]
116096509  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
116098665  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
116098742  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116098857  Atp6v0e2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
116099416  Slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
116099417  Slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
116099516  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
116099529  Slc6a13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
116099530  Slc6a12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
116099943  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
116100285  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
116101672  Napa; alpha-soluble NSF attachment protein isoform X1 [KO:K15296]
116102154  Ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
116102176  Slc17a7; vesicular glutamate transporter 1 isoform X1 [KO:K12302]
116102274  Slc6a5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
116102282  Slc17a6; vesicular glutamate transporter 2 isoform X1 [KO:K12302]
116102457  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
116103034  Stx1b; syntaxin-1B [KO:K08486]
116103231  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
116103300  Tcirg1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116103596  Stx3; syntaxin-3 isoform X1 [KO:K08486]
116103703  Slc1a1; excitatory amino acid transporter 3 [KO:K05612]
116104007  [KO:K11827]
116104058  Slc18a2; synaptic vesicular amine transporter isoform X1 [KO:K08155]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
mcoc04144  Endocytosis
mcoc04724  Glutamatergic synapse
mcoc04725  Cholinergic synapse
mcoc04726  Serotonergic synapse
mcoc04727  GABAergic synapse
mcoc04728  Dopaminergic synapse
KO pathway
ko04721   

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