Entry
Name
Cysteine and methionine metabolism - Mycobacterium canettii CIPT 140070017
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:
M00021 ]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:
M00338 ]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:
M00017 ]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:
M00034 ].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
mcz00270 Cysteine and methionine metabolism
Ortholog table
Module
Other DBs
Organism
Mycobacterium canettii CIPT 140070017 [GN:
mcz ]
Gene
BN45_50692 cysK; Putative cysteine synthase A CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSAse A) [KO:K01738 ] [EC:2.5.1.47 ]
BN45_30118 cbs; Putative cystathionine beta-synthase Cbs (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) [KO:K01697 ] [EC:4.2.1.22 ]
BN45_50841 mmuM; Homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase) [KO:K00547 ] [EC:2.1.1.10 ]
BN45_50445 metH; Putative 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS) [KO:K00548 ] [EC:2.1.1.13 ]
BN45_30483 metK; Putative s-adenosylmethionine synthetase MetK(MAT) (ADOMet synthetase) (methionine adenosyltransferase) [KO:K00789 ] [EC:2.5.1.6 ]
BN45_50992 speE; Putative spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) [KO:K00797 ] [EC:2.5.1.16 ]
BN45_10107 mtn; Putative bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase) [KO:K01243 ] [EC:3.2.2.9 ]
BN45_110067 ask; Aspartokinase Ask (Aspartate Kinase) [contains: aspartokinase alpha subunit (ask-alpha); and aspartokinase beta subunit (ask-beta)] [KO:K00928 ] [EC:2.7.2.4 ]
BN45_110066 asd; Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (Aspartic Semialdehyde Dehydrogenase) (l-Aspartate-beta-Semialdehyde Dehydrogenase) [KO:K00133 ] [EC:1.2.1.11 ]
BN45_10435 metZ; O-succinylhomoserine sulfhydrylase MetZ [KO:K10764 ] [EC:2.5.1.-]
BN45_60115 cysA; Putative thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) [KO:K01011 ] [EC:2.8.1.1 2.8.1.2 ]
BN45_60321 sseA; Putative thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) [KO:K01011 ] [EC:2.8.1.1 2.8.1.2 ]
BN45_20083 Putative thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) (part2) [KO:K01011 ] [EC:2.8.1.1 2.8.1.2 ]
BN45_20137 cysK; Putative cysteine synthase A CysK2 (O-acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSASE) [KO:K22847 ] [EC:2.8.5.1 ]
Compound
C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C00441 L-Aspartate 4-semialdehyde
C01118 O-Succinyl-L-homoserine
C01137 S-Adenosylmethioninamine
C01180 4-Methylthio-2-oxobutanoic acid
C01234 1-Aminocyclopropane-1-carboxylate
C03431 S-Inosyl-L-homocysteine
C03539 S-Ribosyl-L-homocysteine
C04188 S-Methyl-5-thio-D-ribose 1-phosphate
C04582 S-Methyl-5-thio-D-ribulose 1-phosphate
C05526 S-Glutathionyl-L-cysteine
C08276 3-(Methylthio)propanoate
C11437 1-Deoxy-D-xylulose 5-phosphate
C15606 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650 2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049 N-Acyl-L-homoserine lactone
C19787 5'-S-Methyl-5'-thioinosine
C21015 gamma-L-Glutamyl-L-2-aminobutyrate
C22359 S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
Title
Bacterial variations on the methionine salvage pathway.
Journal
Reference
Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
Journal
Reference
Authors
Sekowska A, Danchin A.
Title
The methionine salvage pathway in Bacillus subtilis.
Journal
Reference
Authors
Berger BJ, English S, Chan G, Knodel MH.
Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
Journal
Reference
Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
Journal
Reference
Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
Journal
Reference
Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
Journal
Reference
Authors
Ashida H, Saito Y, Kojima C, Yokota A
Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
Journal
Reference
Authors
Kitabatake M, So MW, Tumbula DL, Soll D
Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
Journal
Reference
Authors
Mino K, Ishikawa K
Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
Journal
Reference
Authors
Tanabe S
Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
Journal
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Journal
Related pathway
mcz00250 Alanine, aspartate and glutamate metabolism
mcz00260 Glycine, serine and threonine metabolism
mcz00290 Valine, leucine and isoleucine biosynthesis
mcz00430 Taurine and hypotaurine metabolism
mcz00770 Pantothenate and CoA biosynthesis
mcz00900 Terpenoid backbone biosynthesis
KO pathway
LinkDB
All DBs