KEGG   PATHWAY: mde00600
Entry
mde00600                    Pathway                                
Name
Sphingolipid metabolism - Musca domestica (house fly)
Class
Metabolism; Lipid metabolism
Pathway map
mde00600  Sphingolipid metabolism
mde00600

Module
mde_M00094  Ceramide biosynthesis [PATH:mde00600]
mde_M00099  Sphingosine biosynthesis [PATH:mde00600]
mde_M00100  Sphingosine degradation [PATH:mde00600]
Other DBs
GO: 0006665
Organism
Musca domestica (house fly) [GN:mde]
Gene
101888364  [KO:K01080] [EC:3.1.3.4]
101888532  [KO:K01080] [EC:3.1.3.4]
101888836  [KO:K12382]
101888890  [KO:K01080] [EC:3.1.3.4]
101889071  [KO:K01080] [EC:3.1.3.4]
101889978  [KO:K01634] [EC:4.1.2.27]
101890389  [KO:K23727]
101890434  [KO:K12309] [EC:3.2.1.23]
101890677  [KO:K17108] [EC:3.2.1.45]
101891709  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
101891875  [KO:K01201] [EC:3.2.1.45]
101891880  [KO:K00654] [EC:2.3.1.50]
101892563  [KO:K00720] [EC:2.4.1.80]
101892784  [KO:K04718] [EC:2.7.1.91]
101893199  [KO:K12373] [EC:3.2.1.52]
101893716  [KO:K01080] [EC:3.1.3.4]
101894273  [KO:K12373] [EC:3.2.1.52]
101894404  [KO:K01080] [EC:3.1.3.4]
101894449  [KO:K04715] [EC:2.7.1.138]
101895662  [KO:K01080] [EC:3.1.3.4]
101895904  [KO:K12349] [EC:3.5.1.23]
101896015  [KO:K04718] [EC:2.7.1.91]
101896506  [KO:K04708] [EC:1.1.1.102]
101896517  [KO:K12373] [EC:3.2.1.52]
101897939  [KO:K01441] [EC:3.5.1.23]
101899571  [KO:K12309] [EC:3.2.1.23]
101900101  [KO:K26283]
101900309  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
101900736  [KO:K00654] [EC:2.3.1.50]
101900853  [KO:K12353] [EC:3.1.4.12]
101901477  [KO:K12350] [EC:3.1.4.12]
101901751  [KO:K01080] [EC:3.1.3.4]
109613654  [KO:K01080] [EC:3.1.3.4]
131800532  [KO:K00654] [EC:2.3.1.50]
131801174  [KO:K01080] [EC:3.1.3.4]
131801175  [KO:K01080] [EC:3.1.3.4]
131801185  [KO:K01080] [EC:3.1.3.4]
131801186  [KO:K01080] [EC:3.1.3.4]
131801635  [KO:K01080] [EC:3.1.3.4]
131802866  [KO:K12350] [EC:3.1.4.12]
131803761  [KO:K01080] [EC:3.1.3.4]
131805472  [KO:K12373] [EC:3.2.1.52]
131805670  [KO:K01080] [EC:3.1.3.4]
131805695  [KO:K01080] [EC:3.1.3.4]
131806438  [KO:K04708] [EC:1.1.1.102]
131806682  [KO:K01080] [EC:3.1.3.4]
131806684  [KO:K01080] [EC:3.1.3.4]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
mde00260  Glycine, serine and threonine metabolism
mde00601  Glycosphingolipid biosynthesis - lacto and neolacto series
mde00603  Glycosphingolipid biosynthesis - globo and isoglobo series
mde00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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