KEGG   PATHWAY: mmat00260
Entry
mmat00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mycolicibacterium mageritense
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mmat00260  Glycine, serine and threonine metabolism
mmat00260

Module
mmat_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mmat00260]
mmat_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mmat00260]
mmat_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:mmat00260]
mmat_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmat00260]
mmat_M00555  Betaine biosynthesis, choline => betaine [PATH:mmat00260]
mmat_M00621  Glycine cleavage system [PATH:mmat00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mycolicibacterium mageritense [GN:mmat]
Gene
MMAGJ_31100  ask; aspartokinase [KO:K00928] [EC:2.7.2.4]
MMAGJ_31110  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MMAGJ_02200  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MMAGJ_02180  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
MMAGJ_02190  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MMAGJ_74800  ltaE; threonine aldolase [KO:K01620] [EC:4.1.2.48]
MMAGJ_05870  glyA1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
MMAGJ_05880  glyA_1; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MMAGJ_13810  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
MMAGJ_50930  glyA_2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MMAGJ_55320  glycerate kinase [KO:K00865] [EC:2.7.1.165]
MMAGJ_63530  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
MMAGJ_38170  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
MMAGJ_53620  serA_3; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MMAGJ_11220  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MMAGJ_52880  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
MMAGJ_76040  aofH; putative flavin-containing monoamine oxidase AofH [KO:K00274] [EC:1.4.3.4]
MMAGJ_31260  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
MMAGJ_38910  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
MMAGJ_49730  monooxygenase [KO:K00274] [EC:1.4.3.4]
MMAGJ_67710  hypothetical protein [KO:K00274] [EC:1.4.3.4]
MMAGJ_04180  amine oxidase [KO:K00276] [EC:1.4.3.21]
MMAGJ_10710  tynA; amine oxidase [KO:K00276] [EC:1.4.3.21]
MMAGJ_55280  amine oxidase [KO:K00276] [EC:1.4.3.21]
MMAGJ_70470  amine oxidase [KO:K00276] [EC:1.4.3.21]
MMAGJ_13840  gcvP_1; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MMAGJ_66720  gcvP_2; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MMAGJ_72460  gcvT_2; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MMAGJ_13830  gcvT_1; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MMAGJ_10230  acoL; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMAGJ_13780  pdhD; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMAGJ_16410  acoD; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMAGJ_25270  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMAGJ_37890  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MMAGJ_13820  gcvH_1; glycine cleavage system H protein [KO:K02437]
MMAGJ_66780  gcvH_2; glycine cleavage system H protein [KO:K02437]
MMAGJ_51430  creatinase [KO:K08688] [EC:3.5.3.3]
MMAGJ_37530  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MMAGJ_51060  choline oxidase [KO:K17755] [EC:1.1.3.17]
MMAGJ_04190  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MMAGJ_10480  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MMAGJ_45970  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MMAGJ_51030  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MMAGJ_50970  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
MMAGJ_50900  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
MMAGJ_50920  soxB; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
MMAGJ_50890  soxG; sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
MMAGJ_50910  soxD; sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
MMAGJ_06110  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MMAGJ_53770  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
MMAGJ_13800  sdaA_1; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MMAGJ_50820  sdaA_2; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MMAGJ_62100  ilvA; L-threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MMAGJ_62530  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
MMAGJ_62520  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
MMAGJ_63610  tryptophan synthase [KO:K06001] [EC:4.2.1.20]
MMAGJ_71010  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
MMAGJ_71020  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
MMAGJ_71000  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
MMAGJ_70990  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mmat00010  Glycolysis / Gluconeogenesis
mmat00020  Citrate cycle (TCA cycle)
mmat00230  Purine metabolism
mmat00250  Alanine, aspartate and glutamate metabolism
mmat00270  Cysteine and methionine metabolism
mmat00290  Valine, leucine and isoleucine biosynthesis
mmat00300  Lysine biosynthesis
mmat00330  Arginine and proline metabolism
mmat00460  Cyanoamino acid metabolism
mmat00470  D-Amino acid metabolism
mmat00564  Glycerophospholipid metabolism
mmat00600  Sphingolipid metabolism
mmat00620  Pyruvate metabolism
mmat00630  Glyoxylate and dicarboxylate metabolism
mmat00640  Propanoate metabolism
mmat00680  Methane metabolism
mmat00860  Porphyrin metabolism
mmat00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system