KEGG   PATHWAY: mmma00564
Entry
mmma00564                   Pathway                                
Name
Glycerophospholipid metabolism - Marmota marmota marmota (Alpine marmot)
Class
Metabolism; Lipid metabolism
Pathway map
mmma00564  Glycerophospholipid metabolism
mmma00564

Module
mmma_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:mmma00564]
mmma_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:mmma00564]
mmma_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:mmma00564]
Other DBs
GO: 0006650
Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107135433  [KO:K00999] [EC:2.7.8.11]
107135506  Gdpd5; glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2 [KO:K28873]
107135792  Dgkz; diacylglycerol kinase zeta isoform X4 [KO:K00901] [EC:2.7.1.107]
107135944  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107135945  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107135947  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107135948  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107136288  Pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
107136530  Agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
107136866  Gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
107137030  Plb1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
107137065  Mboat2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
107137378  Lclat1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
107137440  Selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
107137492  Lpin1; phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
107137643  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
107137645  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
107138189  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
107138195  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
107138257  Lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
107138811  Dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
107138969  Lpin3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
107139064  Dgkq; diacylglycerol kinase theta isoform X3 [KO:K00901] [EC:2.7.1.107]
107139612  Lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
107139827  Cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
107139845  Gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
107139867  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
107139889  Crls1; cardiolipin synthase (CMP-forming) isoform X2 [KO:K08744] [EC:2.7.8.41]
107139969  Chpt1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
107140191  Dgka; diacylglycerol kinase alpha isoform X3 [KO:K00901] [EC:2.7.1.107]
107140572  Lpgat1; LOW QUALITY PROTEIN: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
107140706  Etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
107141072  Dgkh; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
107141374  Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
107141381  Etnppl; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
107141386  Pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
107141569  Pla2g2d; group IID secretory phospholipase A2 isoform X5 [KO:K01047] [EC:3.1.1.4]
107141570  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
107141662  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
107141663  Pla2g5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
107141723  Plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
107142135  Lypla2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
107142174  Pla2g2c; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
107142175  [KO:K01047] [EC:3.1.1.4]
107142176  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
107142391  Lypla1; acyl-protein thioesterase 1 isoform X2 [KO:K06128] [EC:3.1.1.5]
107142521  Ptdss1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
107143204  Pcyt1a; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
107143758  Agpat1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
107144279  Pcyt1b; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
107144862  Lpcat2; lysophosphatidylcholine acyltransferase 2 isoform X4 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
107145119  Gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
107146362  Lpcat1; lysophosphatidylcholine acyltransferase 1 isoform X3 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
107146814  [KO:K01047] [EC:3.1.1.4]
107146929  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
107147083  Ache; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
107147293  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
107148619  Gpd1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
107149128  Dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
107149386  Mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
107149483  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
107149890  Gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
107150420  Dgke; LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
107150474  Phospho1; phosphoethanolamine/phosphocholine phosphatase isoform X2 [KO:K06124] [EC:3.1.3.75]
107150962  Pla2g15; phospholipase A2 group XV isoform X2 [KO:K06129] [EC:3.1.1.5]
107150968  Lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
107151105  Pld4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
107151129  [KO:K13514] [EC:2.3.1.-]
107151458  Pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
107151580  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
107151884  Plpp1; phospholipid phosphatase 1 isoform X4 [KO:K01080] [EC:3.1.3.4]
107152642  Dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
107152723  Etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
107153104  Agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
107153343  Sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
107153454  Chat; choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
107153675  Cds1; phosphatidate cytidylyltransferase 1 isoform X1 [KO:K00981] [EC:2.7.7.41]
107153676  Gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
107154143  Gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
107154348  Dgkg; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
107154792  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
107154927  Lpcat3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
107155389  Plpp5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
107157020  Chka; choline kinase alpha isoform X3 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
107157109  Ptdss2; phosphatidylserine synthase 2 isoform X3 [KO:K08730] [EC:2.7.8.29]
107157158  Pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
107157338  Pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X5 [KO:K14676] [EC:3.1.1.5]
107157386  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
107157688  [KO:K00967] [EC:2.7.7.14]
107157848  Pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
107157906  Gnpat; dihydroxyacetone phosphate acyltransferase isoform X3 [KO:K00649] [EC:2.3.1.42]
107158046  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
107158146  Samd8; sphingomyelin synthase-related protein 1 isoform X2 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
107158189  Agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
107158470  Pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
107158504  Pla2g3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
107158596  Cept1; choline/ethanolaminephosphotransferase 1 isoform X2 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
107158682  Pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
107158902  Mboat7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
107159154  Pnpla7; patatin-like phospholipase domain-containing protein 7 isoform X9 [KO:K14676] [EC:3.1.1.5]
107159200  Agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1 [KO:K13509] [EC:2.3.1.51]
107159403  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
107159635  Gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
107159807  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
107160254  Chkb; choline/ethanolamine kinase isoform X2 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
107160289  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
107160306  Tafazzin; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
125612043  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
125612720  Plpp4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
mmma00010  Glycolysis / Gluconeogenesis
mmma00260  Glycine, serine and threonine metabolism
mmma00561  Glycerolipid metabolism
mmma00562  Inositol phosphate metabolism
mmma00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
mmma00565  Ether lipid metabolism
mmma00620  Pyruvate metabolism
KO pathway
ko00564   

DBGET integrated database retrieval system