KEGG   PATHWAY: mrf00230
Entry
mrf00230                    Pathway                                
Name
Purine metabolism - Mycolicibacterium rufum
Class
Metabolism; Nucleotide metabolism
Pathway map
mrf00230  Purine metabolism
mrf00230

Module
mrf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mrf00230]
mrf_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mrf00230]
mrf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mrf00230]
mrf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mrf00230]
mrf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mrf00230]
mrf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mrf00230]
Other DBs
GO: 0006163 0042278
Organism
Mycolicibacterium rufum [GN:mrf]
Gene
MJO55_08850  pgm; phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) [KO:K01835] [EC:5.4.2.2]
MJO55_21800  ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
MJO55_23285  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
MJO55_23465  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
MJO55_22175  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
MJO55_02460  purT; formate-dependent phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
MJO55_23310  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
MJO55_23350  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
MJO55_23345  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
MJO55_23265  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
MJO55_07380  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
MJO55_07400  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
MJO55_23415  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
MJO55_23435  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
MJO55_22170  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MJO55_11610  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MJO55_09915  HAD-IIA family hydrolase [KO:K02566] [EC:3.1.3.5]
MJO55_06715  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
MJO55_16365  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MJO55_06260  nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
MJO55_24580  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
MJO55_06185  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
MJO55_06190  GuaB3 family IMP dehydrogenase-related protein [KO:K00088] [EC:1.1.1.205]
MJO55_17975  ndk; nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
MJO55_19445  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
MJO55_09315  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
MJO55_09325  FAD binding domain-containing protein [KO:K11178] [EC:1.17.1.4]
MJO55_09320  2Fe-2S iron-sulfur cluster-binding protein [KO:K13483]
MJO55_06205  guaA; glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
MJO55_14665  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
MJO55_14135  GuaB1 family IMP dehydrogenase-related protein [KO:K26110] [EC:1.7.1.7]
MJO55_12080  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
MJO55_09190  nrdE; class 1b ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
MJO55_09250  nrdF; class 1b ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
MJO55_15885  R2-like ligand-binding oxidase [KO:K00526] [EC:1.17.4.1]
MJO55_17300  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
MJO55_11615  RelA/SpoT family protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MJO55_03385  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MJO55_21720  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MJO55_23555  HAMP domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_24670  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_06010  HAMP domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_06670  AAA family ATPase [KO:K01768] [EC:4.6.1.1]
MJO55_08560  AAA family ATPase [KO:K01768] [EC:4.6.1.1]
MJO55_12950  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_19320  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_20020  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_09235  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_20875  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
MJO55_26860  response regulator [KO:K01768] [EC:4.6.1.1]
MJO55_02420  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
MJO55_16600  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
MJO55_06650  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
MJO55_05535  adenylate kinase [KO:K00939] [EC:2.7.4.3]
MJO55_21760  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MJO55_11470  HIT domain-containing protein [KO:K19710] [EC:2.7.7.53]
MJO55_01715  cysC; adenylyl-sulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MJO55_19850  cysN; sulfate adenylyltransferase subunit CysN [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MJO55_01720  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
MJO55_19855  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
MJO55_24605  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
MJO55_14175  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MJO55_14170  urease subunit beta [KO:K01429] [EC:3.5.1.5]
MJO55_14165  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
MJO55_08160  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mrf00030  Pentose phosphate pathway
mrf00220  Arginine biosynthesis
mrf00250  Alanine, aspartate and glutamate metabolism
mrf00260  Glycine, serine and threonine metabolism
mrf00340  Histidine metabolism
mrf00630  Glyoxylate and dicarboxylate metabolism
mrf00730  Thiamine metabolism
mrf00740  Riboflavin metabolism
mrf00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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