KEGG   PATHWAY: mrf00260
Entry
mrf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Mycolicibacterium rufum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mrf00260  Glycine, serine and threonine metabolism
mrf00260

Module
mrf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mrf00260]
mrf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mrf00260]
mrf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mrf00260]
mrf_M00555  Betaine biosynthesis, choline => betaine [PATH:mrf00260]
mrf_M00621  Glycine cleavage system [PATH:mrf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mycolicibacterium rufum [GN:mrf]
Gene
MJO55_25070  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MJO55_25065  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MJO55_19710  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MJO55_19700  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
MJO55_19705  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MJO55_04725  beta-eliminating lyase-related protein [KO:K01620] [EC:4.1.2.48]
MJO55_21060  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MJO55_16615  glycerate kinase [KO:K00865] [EC:2.7.1.165]
MJO55_03300  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
MJO55_09575  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MJO55_22875  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
MJO55_09360  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
MJO55_25430  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
MJO55_08295  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
MJO55_21335  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
MJO55_10040  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
MJO55_15520  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
MJO55_13935  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MJO55_16640  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
MJO55_03160  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MJO55_13910  gcvH; glycine cleavage system protein GcvH [KO:K02437]
MJO55_02920  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
MJO55_02030  iron-containing alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
MJO55_15765  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
MJO55_06495  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MJO55_15775  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
MJO55_15790  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
MJO55_15785  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
MJO55_21160  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MJO55_09665  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
MJO55_00060  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MJO55_12635  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
MJO55_04465  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
MJO55_12815  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
MJO55_12810  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mrf00010  Glycolysis / Gluconeogenesis
mrf00020  Citrate cycle (TCA cycle)
mrf00230  Purine metabolism
mrf00250  Alanine, aspartate and glutamate metabolism
mrf00270  Cysteine and methionine metabolism
mrf00290  Valine, leucine and isoleucine biosynthesis
mrf00300  Lysine biosynthesis
mrf00330  Arginine and proline metabolism
mrf00460  Cyanoamino acid metabolism
mrf00470  D-Amino acid metabolism
mrf00564  Glycerophospholipid metabolism
mrf00600  Sphingolipid metabolism
mrf00620  Pyruvate metabolism
mrf00630  Glyoxylate and dicarboxylate metabolism
mrf00640  Propanoate metabolism
mrf00680  Methane metabolism
mrf00860  Porphyrin metabolism
mrf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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