KEGG   PATHWAY: mtd00984
Entry
mtd00984                    Pathway                                
Name
Steroid degradation - Mycobacterium tuberculosis UT205
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mtd00984  Steroid degradation
mtd00984

Other DBs
GO: 0006707
Organism
Mycobacterium tuberculosis UT205 [GN:mtd]
Gene
UDA_0130  [KO:K28224]
UDA_0760c  [KO:K01822] [EC:5.3.3.1]
UDA_0855  far; far [KO:K01796] [EC:5.1.99.4]
UDA_1106c  [KO:K16045] [EC:1.1.1.145 5.3.3.1]
UDA_1143  mcr; mcr [KO:K01796] [EC:5.1.99.4]
UDA_1935c  echA13; echA13 [KO:K28232]
UDA_2790c  ltp1; ltp1 [KO:K00632] [EC:2.3.1.16]
UDA_3409c  choD; choD [KO:K03333] [EC:1.1.3.6]
UDA_3502c  [KO:K28219]
UDA_3504  fadE26; fadE26 [KO:K22818] [EC:1.3.99.-]
UDA_3505  fadE27; fadE27 [KO:K22819] [EC:1.3.99.-]
UDA_3518c  cyp142; cyp142 [KO:K16046] [EC:1.14.15.28]
UDA_3526  [KO:K15982] [EC:1.14.15.30]
UDA_3537  [KO:K05898] [EC:1.3.99.4]
UDA_3538  [KO:K28218]
UDA_3540c  ltp2; ltp2 [KO:K25623]
UDA_3541c  [KO:K25622]
UDA_3542c  [KO:K25621]
UDA_3543c  fadE29; fadE29 [KO:K22822] [EC:1.3.99.-]
UDA_3544c  fadE28; fadE28 [KO:K22821] [EC:1.3.99.-]
UDA_3545c  cyp125; cyp125 [KO:K15981] [EC:1.14.15.29]
UDA_3546  fadA5; fadA5 [KO:K00632] [EC:2.3.1.16]
UDA_3548c  [KO:K28225]
UDA_3550  echA20; echA20 [KO:K28227]
UDA_3551  [KO:K28228]
UDA_3552  [KO:K28229]
UDA_3553  [KO:K28226]
UDA_3556c  fadA6; fadA6 [KO:K00632] [EC:2.3.1.16]
UDA_3559c  [KO:K28220]
UDA_3560c  fadE30; fadE30 [KO:K28222]
UDA_3561  fadD3; fadD3 [KO:K18687] [EC:6.2.1.41]
UDA_3562  fadE31; fadE31 [KO:K28230]
UDA_3563  fadE32; fadE32 [KO:K28231]
UDA_3564  fadE33; fadE33 [KO:K28221]
UDA_3567c  [KO:K16048] [EC:1.5.1.-]
UDA_3568c  bphC; bphC [KO:K16049] [EC:1.13.11.25]
UDA_3569c  bphD; bphD [KO:K16050] [EC:3.7.1.17]
UDA_3570c  [KO:K16047] [EC:1.14.14.12]
UDA_3571  hmp; hmp [KO:K15983] [EC:1.14.15.30]
UDA_3573c  fadE34; fadE34 [KO:K22820] [EC:1.3.99.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00187  Cholesterol
C00280  Androstenedione
C00479  Propanal
C00535  Testosterone
C00599  Cholest-4-en-3-one
C00674  5alpha-Androstane-3,17-dione
C01227  Dehydroepiandrosterone
C04793  3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C04844  3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
C06762  4-Hydroxy-2-oxohexanoic acid
C07635  Epiandrosterone
C11354  2-Hydroxy-cis-hex-2,4-dienoate
C14909  9alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C19944  3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C20144  Androsta-1,4-diene-3,17-dione
C20199  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
C20252  5-Androstene-3,17-dione
C20838  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
C20839  (25R)-3-Oxocholest-4-en-26-oate
C20840  (25S)-3-Oxocholest-4-en-26-oyl-CoA
C21076  Delta4-Dafachronic acid
C21906  3-Oxochol-4-en-24-oyl-CoA
C23003  3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]propanoyl-CoA
C23004  (2E)-3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]prop-2-enoyl-CoA
C23005  3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA
C23006  3-[(3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA
C23007  (3aS,4S,5R,7aS)-5-Hydroxy-7a-methyl-1-oxooctahydro-1H-indene-4-carboxyl-CoA
C23009  (7aS)-7a-Methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxyl-CoA
C23010  3-Oxocholest-4,24-dien-26-oyl-CoA
C23011  (25R)-3-Oxocholest-4-en-26-oyl-CoA
C23012  24-Hydroxy-3-oxocholest-4-en-26-oyl-CoA
C23013  3,24-Dioxocholest-4-en-26-oyl-CoA
C23014  3-Oxochol-4,22-dien-24-oyl-CoA
C23015  (22S)-Hydroxy-3-oxochol-4-en-24-oyl-CoA
C23016  3,22-Dioxochol-4-en-24-oyl-CoA
C23017  3-Oxopregnene-20-carboxyl-CoA
C23018  3-Oxo-4,17-pregnadiene-20-carboxyl-CoA
C23019  17-Hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA
C23020  (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA
C23021  9-Carboxy-6-methyl-3,7-dioxononanoyl-CoA
C23022  7-Carboxy-4-methyl-5-oxoheptanoyl-CoA
C23023  (2E)-7-Carboxy-4-methyl-5-oxohept-2-enoyl-CoA
C23024  7-Carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA
C23025  7-Carboxy-4-methyl-3,5-dioxoheptanoyl-CoA
C23026  5-Carboxy-2-methyl-3-oxopentanoyl-CoA
Reference
PMID:31284586
  Authors
Olivera ER, Luengo JM.
  Title
Steroids as Environmental Compounds Recalcitrant to Degradation: Genetic  Mechanisms of Bacterial Biodegradation Pathways.
  Journal
Genes (Basel) 10 (2019)
DOI:10.3390/genes10070512
Reference
PMID:21056662
  Authors
Horinouchi M, Hayashi T, Kudo T
  Title
Steroid degradation in Comamonas testosteroni.
  Journal
J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008
Reference
PMID:20554032
  Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
  Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
  Journal
J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002
Reference
PMID:34232729
  Authors
Horinouchi M, Hayashi T.
  Title
Identification of the Coenzyme A (CoA) Ester Intermediates and Genes Involved in  the Cleavage and Degradation of the Steroidal C-Ring by Comamonas testosteroni  TA441.
  Journal
Appl Environ Microbiol 87:e0110221 (2021)
DOI:10.1128/AEM.01102-21
Reference
PMID:37815361
  Authors
Horinouchi M, Hayashi T.
  Title
Comprehensive summary of steroid metabolism in Comamonas testosteroni TA441:  entire degradation process of basic four rings and removal of C12 hydroxyl group.
  Journal
Appl Environ Microbiol 89:e0014323 (2023)
DOI:10.1128/aem.00143-23
Reference
PMID:21924910
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
Reference
PMID:17264217
  Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
  Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
  Journal
Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104
Reference
PMID:22045806
  Authors
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
  Title
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
  Journal
J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643
Reference
PMID:28377529
  Authors
Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD.
  Title
Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other  Bacteria.
  Journal
mBio 8 (2017)
DOI:10.1128/mBio.00321-17
Reference
PMID:33826843
  Authors
Yuan T, Werman JM, Yin X, Yang M, Garcia-Diaz M, Sampson NS.
  Title
Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis  Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.
  Journal
ACS Infect Dis 7:1739-1751 (2021)
DOI:10.1021/acsinfecdis.1c00069
Related
pathway
mtd00010  Glycolysis / Gluconeogenesis
mtd00020  Citrate cycle (TCA cycle)
mtd00640  Propanoate metabolism
KO pathway
ko00984   

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