KEGG   PATHWAY: mtu00230
Entry
mtu00230                    Pathway                                
Name
Purine metabolism - Mycobacterium tuberculosis H37Rv
Class
Metabolism; Nucleotide metabolism
Pathway map
mtu00230  Purine metabolism
mtu00230

Module
mtu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mtu00230]
mtu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mtu00230]
mtu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mtu00230]
mtu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mtu00230]
mtu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mtu00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium tuberculosis H37Rv [GN:mtu]
Gene
Rv0233  nrdB; ribonucleoside-diphosphate reductase subunit beta NrdB [KO:K00526] [EC:1.17.4.1]
Rv0357c  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Rv0389  purT; phosphoribosylglycinamide formyltransferase PurT [KO:K08289] [EC:6.3.1.21]
Rv0496  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Rv0570  nrdZ; vitamin B12-dependent ribonucleoside-diphosphate reductase [KO:K00525] [EC:1.17.4.1]
Rv0733  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
Rv0772  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
Rv0777  purB; adenylosuccinate lyase PurB [KO:K01756] [EC:4.3.2.2]
Rv0780  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
Rv0787A  [KO:K23264]
Rv0788  purQ; phosphoribosylformylglycinamidine synthase [KO:K23265]
Rv0803  purL; phosphoribosylformylglycinamidine synthase 2 [KO:K23269]
Rv0805  [KO:K03651] [EC:3.1.4.53]
Rv0808  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
Rv0809  purM; phosphoribosylformylglycinamidine cyclo-ligase PurM [KO:K01933] [EC:6.3.3.1]
Rv0956  purN; phosphoribosylglycinamide formyltransferase PurN [KO:K11175] [EC:2.1.2.2]
Rv0957  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosinemonophosphate cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Rv1017c  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
Rv1021  [KO:K04765] [EC:3.6.1.9]
Rv1026  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Rv1264  [KO:K01768] [EC:4.6.1.1]
Rv1285  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
Rv1286  [KO:K00955] [EC:2.7.7.4 2.7.1.25]
Rv1341  [KO:K01519] [EC:3.6.1.66]
Rv1389  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
Rv1625c  cya; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
Rv1843c  guaB1; inosine-5'-monophosphate dehydrogenase [KO:K26110]
Rv1848  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Rv1849  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
Rv1850  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
Rv1981c  nrdF1; ribonucleoside-diphosphate reductase subunit beta NrdF1 [KO:K00526] [EC:1.17.4.1]
Rv2149c  yfiH; laccase domain-containing protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
Rv2202c  adoK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
Rv2344c  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
Rv2445c  ndkA; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
Rv2583c  relA; bifunctional (p)ppGpp synthase/hydrolase RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Rv2584c  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
Rv2613c  [KO:K19710] [EC:2.7.7.53]
Rv3048c  nrdF2; ribonucleoside-diphosphate reductase subunit beta NrdF2 [KO:K00526] [EC:1.17.4.1]
Rv3051c  nrdE; ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
Rv3068c  pgmA; phosphoglucomutase PgmA [KO:K01835] [EC:5.4.2.2]
Rv3275c  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
Rv3276c  purK; 5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
Rv3307  deoD; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
Rv3313c  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
Rv3393  iunH; nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
Rv3396c  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
Rv3410c  guaB3; oxidoreductase [KO:K00088] [EC:1.1.1.205]
Rv3411c  guaB2; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
Rv3624c  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Rv3645  [KO:K01768] [EC:4.6.1.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mtu00030  Pentose phosphate pathway
mtu00220  Arginine biosynthesis
mtu00250  Alanine, aspartate and glutamate metabolism
mtu00260  Glycine, serine and threonine metabolism
mtu00340  Histidine metabolism
mtu00630  Glyoxylate and dicarboxylate metabolism
mtu00730  Thiamine metabolism
mtu00740  Riboflavin metabolism
mtu00790  Folate biosynthesis
KO pathway
ko00230   

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