KEGG   PATHWAY: nak00260
Entry
nak00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Nakamurella antarctica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nak00260  Glycine, serine and threonine metabolism
nak00260

Module
nak_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nak00260]
nak_M00555  Betaine biosynthesis, choline => betaine [PATH:nak00260]
nak_M00621  Glycine cleavage system [PATH:nak00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Nakamurella antarctica [GN:nak]
Gene
EH165_02080  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EH165_02085  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EH165_08455  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EH165_08445  homoserine kinase [KO:K00872] [EC:2.7.1.39]
EH165_08450  threonine synthase [KO:K01733] [EC:4.2.3.1]
EH165_03365  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EH165_01970  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EH165_14345  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EH165_13380  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
EH165_13510  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
EH165_02965  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
EH165_09560  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EH165_05170  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EH165_09105  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EH165_09120  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EH165_05140  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EH165_02760  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
EH165_03065  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EH165_03050  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EH165_01575  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EH165_10990  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EH165_03045  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
EH165_03030  FAD-dependent oxidoreductase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
EH165_03040  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
EH165_03035  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
EH165_03620  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
EH165_03630  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
EH165_13770  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
EH165_14480  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EH165_00430  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
EH165_08180  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
EH165_06665  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nak00010  Glycolysis / Gluconeogenesis
nak00020  Citrate cycle (TCA cycle)
nak00230  Purine metabolism
nak00250  Alanine, aspartate and glutamate metabolism
nak00270  Cysteine and methionine metabolism
nak00290  Valine, leucine and isoleucine biosynthesis
nak00300  Lysine biosynthesis
nak00330  Arginine and proline metabolism
nak00460  Cyanoamino acid metabolism
nak00470  D-Amino acid metabolism
nak00564  Glycerophospholipid metabolism
nak00600  Sphingolipid metabolism
nak00620  Pyruvate metabolism
nak00630  Glyoxylate and dicarboxylate metabolism
nak00640  Propanoate metabolism
nak00680  Methane metabolism
nak00860  Porphyrin metabolism
nak00920  Sulfur metabolism
KO pathway
ko00260   
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