KEGG   PATHWAY: nau00053
Entry
nau00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Nicotiana attenuata (coyote tobacco)
Class
Metabolism; Carbohydrate metabolism
Pathway map
nau00053  Ascorbate and aldarate metabolism
nau00053

Module
nau_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:nau00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Nicotiana attenuata (coyote tobacco) [GN:nau]
Gene
109227483  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
109212520  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
109242584  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
109234574  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
109218818  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
109234273  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
109216836  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
109219967  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
109220333  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
109227168  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
109231369  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
109240336  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
109229579  LOW QUALITY PROTEIN: aldose reductase [KO:K00002] [EC:1.1.1.2]
109229463  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
109213786  probable L-gulonolactone oxidase 6 isoform X1 [KO:K00103] [EC:1.1.3.8]
109214899  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
109229242  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
109210224  GDP-mannose 3,5-epimerase 1-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
109220842  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
109207148  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
109211106  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
109207069  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
109242737  LOW QUALITY PROTEIN: inositol monophosphatase 1-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
109214303  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
109209275  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
109213673  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
109213589  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
109233051  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
109205898  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
109206685  UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
109213482  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
109215700  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
109224890  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
109235680  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
109211977  UDP-glucuronate 4-epimerase 2-like [KO:K08679] [EC:5.1.3.6]
109227689  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
109208804  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
109216145  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
109216755  monodehydroascorbate reductase 5, mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
109229738  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
109232426  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
109215800  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
109238727  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
109229383  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
109209066  probable L-ascorbate peroxidase 6, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
109208242  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
109208522  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
109208525  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
109208571  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
109218056  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109213372  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109218954  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
109218986  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
109225318  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
109215608  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
109241711  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
109237512  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
109210903  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
109211953  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
109227124  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
109235412  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
109226769  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
109240285  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
109242120  aldehyde dehydrogenase family 2 member B4, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
109212832  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
nau00020  Citrate cycle (TCA cycle)
nau00040  Pentose and glucuronate interconversions
nau00051  Fructose and mannose metabolism
nau00520  Amino sugar and nucleotide sugar metabolism
nau00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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