KEGG   PATHWAY: npd04382
Entry
npd04382                    Pathway                                
Name
Cornified envelope formation - Nothoprocta perdicaria (Chilean tinamou)
Class
Organismal Systems; Development and regeneration
Pathway map
npd04382  Cornified envelope formation
npd04382

Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942334  ELOVL1; elongation of very long chain fatty acids protein 1 [KO:K10247] [EC:2.3.1.199]
112942666  [KO:K06087]
112942667  [KO:K06087]
112942687  [KO:K06087]
112942999  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
112943129  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
112943146  DST; dystonin [KO:K10382]
112943397  KDSR; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
112944133  LAMA3; laminin subunit alpha-3 [KO:K06240]
112944488  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
112944529  CLDN2; claudin-2 [KO:K06087]
112944559  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
112944584  LAMB3; laminin subunit beta-3 [KO:K06244]
112944597  PNPLA1; patatin-like phospholipase domain-containing protein 1 [KO:K16813] [EC:2.3.1.296]
112944708  [KO:K07604]
112944711  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
112944881  CLDN18; claudin-18 isoform X1 [KO:K06087]
112944886  [KO:K06087]
112945128  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112945133  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
112945982  CLDN5; claudin-5 [KO:K06087]
112946604  ELOVL4; elongation of very long chain fatty acids protein 4 [KO:K10249] [EC:2.3.1.199]
112947261  ST14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
112947402  CLDN12; claudin-12 [KO:K06087]
112947868  [KO:K06237]
112947929  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
112948099  CLDN25; putative claudin-25 [KO:K06087]
112948145  PKP2; plakophilin-2 [KO:K12642]
112948238  CLDN10; claudin-10 isoform X1 [KO:K06087]
112948296  CERS3; ceramide synthase 3 [KO:K24622]
112948330  PCSK6; proprotein convertase subtilisin/kexin type 6 [KO:K08672] [EC:3.4.21.-]
112948343  FURIN; furin [KO:K01349] [EC:3.4.21.75]
112948516  UGCG; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
112948985  [KO:K07604]
112948986  [KO:K07604]
112948987  KRT23; LOW QUALITY PROTEIN: keratin, type I cytoskeletal 23 [KO:K07604]
112948988  KRT20; keratin, type I cytoskeletal 20 [KO:K07604]
112948990  [KO:K07604]
112948991  [KO:K07604]
112948994  [KO:K07604]
112949004  [KO:K07604]
112949010  [KO:K07604]
112949011  [KO:K07604]
112949012  [KO:K07604]
112949077  OCLN; occludin [KO:K06088]
112949124  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
112949327  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
112949619  LAMA5; laminin subunit alpha-5 [KO:K06240]
112950678  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112950792  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112951535  LAMC2; laminin subunit gamma-2 [KO:K06246]
112951631  CLDN20; claudin-20 [KO:K06087]
112951844  JUP; junction plakoglobin [KO:K10056]
112952012  DSP; desmoplakin isoform X1 [KO:K10381]
112952173  GBA2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
112952396  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112952479  CLDN1; claudin-1 [KO:K06087]
112952481  CLDN11; claudin-11 isoform X1 [KO:K06087]
112952556  CLDN16; claudin-16 [KO:K06087]
112952633  ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [KO:K13699] [EC:2.3.1.51]
112952984  [KO:K01201] [EC:3.2.1.45]
112953000  GBA; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
112953001  [KO:K01201] [EC:3.2.1.45]
112953161  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112953421  CLDN23; claudin-23 [KO:K06087]
112953464  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112953484  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
112953514  SPTLC1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
112953557  S100A11; protein S100-A11 [KO:K23765]
112953593  TMEM79; transmembrane protein 79 [KO:K28333]
112953665  ITGB4; integrin beta-4 [KO:K06525]
112953967  CLDN34; claudin-34 [KO:K06087]
112954103  [KO:K21128]
112954107  [KO:K21126]
112954112  [KO:K23764]
112954114  [KO:K23761]
112954117  [KO:K21128]
112954120  S100A16; protein S100-A16 [KO:K23768]
112954122  [KO:K23767]
112954123  S100A1; protein S100-A1 [KO:K23758]
112954181  [KO:K07605]
112954182  [KO:K07605]
112954183  [KO:K07605]
112954187  [KO:K07605]
112954188  KRT80; keratin, type II cytoskeletal 80 [KO:K07605]
112954189  [KO:K07605]
112954192  [KO:K07605]
112954193  [KO:K07605]
112954194  [KO:K07605]
112954629  BLMH; bleomycin hydrolase [KO:K01372] [EC:3.4.22.40]
112954757  ABCA12; ATP-binding cassette sub-family A member 12 [KO:K05646]
112954896  SLC27A1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
112954995  SPTLC2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
112955037  [KO:K05620] [EC:2.3.2.13]
112955163  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112955233  S100A10; protein S100-A10 [KO:K17274]
112955235  [KO:K17731] [EC:1.14.14.177]
112955317  [KO:K07605]
112955318  [KO:K07605]
112955319  [KO:K07605]
112955320  KRT8; keratin, type II cytoskeletal 8 [KO:K07605]
112955321  KRT18; keratin, type I cytoskeletal 18 [KO:K07604]
112955322  [KO:K07605]
112955723  PPL; periplakin [KO:K10386]
112956105  SLC27A4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
112956169  [KO:K07599]
112956182  DSG2; desmoglein-2 [KO:K07597]
112956672  [KO:K06087]
112956702  [KO:K06087]
112956726  [KO:K06087]
112956767  PLEC; plectin [KO:K10388]
112956925  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112957136  COL17A1; collagen alpha-1(XVII) chain [KO:K07603]
112957430  CLDN19; claudin-19 [KO:K06087]
112957431  [KO:K06087]
112957522  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
112957670  EVPL; envoplakin [KO:K10383]
112958031  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
112958712  COL7A1; collagen alpha-1(VII) chain [KO:K16628]
112958897  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
112958968  SPTLC3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
112959070  CLDN14; claudin-14 [KO:K06087]
112959231  PKP1; plakophilin-1 isoform X1 [KO:K10387]
112959448  HAL; histidine ammonia-lyase [KO:K01745] [EC:4.3.1.3]
112959547  [KO:K01481] [EC:3.5.3.15]
112959600  [KO:K01481] [EC:3.5.3.15]
112959607  [KO:K01481] [EC:3.5.3.15]
112959658  KAZN; kazrin [KO:K28344]
112959671  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
Compound
C00064  L-Glutamine
C00076  Calcium cation
C00135  L-Histidine
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00187  Cholesterol
C00785  Urocanate
C00836  Sphinganine
C01879  5-Oxoproline
C02934  3-Dehydrosphinganine
C22352  Ultra-long-chain fatty acid
C22353  Ultra-long-chain omega-hydroxy fatty acid
C23027  Ultra-long-chain omega-hydroxy fatty acyl-CoA
C23028  Ultra-long-chain omega-hydroxyceramide
C23029  linoleate-esterified acylceramide
C23030  Acylglucosylceramide
Reference
PMID:15803139
  Authors
Candi E, Schmidt R, Melino G
  Title
The cornified envelope: a model of cell death in the skin.
  Journal
Nat Rev Mol Cell Biol 6:328-40 (2005)
DOI:10.1038/nrm1619
Reference
PMID:29153780
  Authors
Egawa G, Kabashima K
  Title
Barrier dysfunction in the skin allergy.
  Journal
Allergol Int 67:3-11 (2018)
DOI:10.1016/j.alit.2017.10.002
Reference
PMID:32218335
  Authors
Ishitsuka Y, Roop DR
  Title
Loricrin: Past, Present, and Future.
  Journal
Int J Mol Sci 21:ijms21072271 (2020)
DOI:10.3390/ijms21072271
Reference
PMID:34639001
  Authors
Gallegos-Alcala P, Jimenez M, Cervantes-Garcia D, Salinas E
  Title
The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.
  Journal
Int J Mol Sci 22:ijms221910661 (2021)
DOI:10.3390/ijms221910661
Reference
PMID:30776025
  Authors
Goleva E, Berdyshev E, Leung DY
  Title
Epithelial barrier repair and prevention of allergy.
  Journal
J Clin Invest 129:1463-1474 (2019)
DOI:10.1172/JCI124608
Reference
PMID:23954553
  Authors
Breiden B, Sandhoff K
  Title
The role of sphingolipid metabolism in cutaneous permeability barrier formation.
  Journal
Biochim Biophys Acta 1841:441-52 (2014)
DOI:10.1016/j.bbalip.2013.08.010
Reference
PMID:31974308
  Authors
Yamamoto H, Hattori M, Chamulitrat W, Ohno Y, Kihara A
  Title
Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid omega-O-acylceramide.
  Journal
Proc Natl Acad Sci U S A 117:2914-2922 (2020)
DOI:10.1073/pnas.1917525117
Reference
PMID:36902463
  Authors
Ge F, Sun K, Hu Z, Dong X
  Title
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method.
  Journal
Int J Mol Sci 24:ijms24055035 (2023)
DOI:10.3390/ijms24055035
Related
pathway
npd00600  Sphingolipid metabolism
KO pathway
ko04382   

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