KEGG   PATHWAY: npr04814
Entry
npr04814                    Pathway                                
Name
Motor proteins - Nanorana parkeri (Xizang Plateau frog)
Class
Cellular Processes; Cell motility
Pathway map
npr04814  Motor proteins
npr04814

Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108788628  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
108795963  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
108800485  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
108790504  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
108795244  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
108795673  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
108791882  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
108787760  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
108787359  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
108786166  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
108786806  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
108793482  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
108784646  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
108801814  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
108792336  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
108787385  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
108787051  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
108784922  dynein heavy chain 3, axonemal-like [KO:K10408]
108788892  dynein heavy chain 5, axonemal-like [KO:K10408]
108786877  DNAH12; LOW QUALITY PROTEIN: dynein heavy chain 12, axonemal [KO:K10408]
108788190  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
108801579  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
108800300  dynein heavy chain 11, axonemal-like [KO:K10408]
108791720  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
108804527  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
108800883  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
108791498  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
108793424  DNAH1; LOW QUALITY PROTEIN: dynein heavy chain 1, axonemal [KO:K10408]
108799591  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
108796712  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
108791370  WDR63; WD repeat-containing protein 63 [KO:K24722]
108792334  WDR78; WD repeat-containing protein 78 [KO:K24723]
108787636  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
108793927  DNAL1; dynein light chain 1, axonemal [KO:K10411]
108795136  DNAL4; dynein light chain 4, axonemal [KO:K10412]
108796951  DCTN1; dynactin subunit 1 [KO:K04648]
108797989  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
108786312  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
108790988  DCTN5; dynactin subunit 5 [KO:K10427]
108796407  DCTN6; dynactin subunit 6 [KO:K10428]
108784575  ACTR1A; alpha-centractin [KO:K16575]
108791731  ACTR10; actin-related protein 10 [KO:K16576]
108802057  F-actin-capping protein subunit alpha-2-like [KO:K10364]
108802147  F-actin-capping protein subunit alpha-2 [KO:K10364]
108802221  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
108800095  BICDL1; bicaudal D-related protein 1 [KO:K16756]
108803818  BICDL2; bicaudal D-related protein 2 [KO:K16756]
108792569  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
108787374  tubulin alpha-1 chain-like [KO:K07374]
108785785  tubulin alpha-1A chain-like [KO:K07374]
108794967  tubulin alpha-8 chain-like [KO:K07374]
108794992  tubulin alpha-3 chain [KO:K07374]
108791579  TUBA8; tubulin alpha-8 chain [KO:K07374]
108798525  tubulin alpha-1A chain-like [KO:K07374]
108798526  tubulin alpha chain [KO:K07374]
108799640  tubulin alpha-1A chain-like [KO:K07374]
108799641  tubulin alpha-1A chain-like [KO:K07374]
108799643  tubulin alpha chain isoform X1 [KO:K07374]
108791406  tubulin alpha-1A chain [KO:K07374]
108795276  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
108793408  tubulin beta-2B chain isoform X1 [KO:K07375]
108790400  TUBB; tubulin beta chain [KO:K07375]
108794619  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
108798203  tubulin beta-4B chain-like isoform X1 [KO:K07375]
108802729  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
108787331  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
108789369  tubulin beta-4B chain-like [KO:K07375]
108789370  tubulin beta-4B chain isoform X1 [KO:K07375]
108796327  TUBG1; tubulin gamma-1 chain [KO:K10389]
108798075  TUBD1; LOW QUALITY PROTEIN: tubulin delta chain [KO:K10390]
108790089  TUBE1; tubulin epsilon chain [KO:K10391]
108798020  KIF5A; kinesin heavy chain [KO:K10396]
108795508  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
108792464  KIF5B; kinesin-1 heavy chain [KO:K10396]
108796462  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
108787059  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
108792432  KIF3A; kinesin-like protein KIF3A [KO:K10394]
108786995  KIF3B; kinesin-like protein KIF3B [KO:K20196]
108793702  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
108801963  KIF3C; kinesin-like protein KIF3C [KO:K20197]
108803365  KIF17; kinesin-like protein KIF17 [KO:K20198]
108783824  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
108789753  KIF1C; kinesin-like protein KIF1C isoform X1 [KO:K10392]
108796430  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
108789579  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
108798347  KIF13B; LOW QUALITY PROTEIN: kinesin-like protein KIF13B [KO:K17914]
108797827  KIF14; kinesin-like protein KIF14 [KO:K17915]
108793305  KIF16B; kinesin-like protein KIF16B [KO:K17916]
108793918  STARD9; stAR-related lipid transfer protein 9 [KO:K16491]
108800184  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
108799638  KIF7; kinesin-like protein KIF7 [KO:K18806]
108783839  KIF21A; kinesin-like protein KIF21A [KO:K24185]
108804909  KIF21B; kinesin-like protein KIF21B [KO:K24185]
108791219  KIF27; kinesin-like protein KIF27 [KO:K24186]
108788824  KIF11; kinesin-like protein KIF11 [KO:K10398]
108789960  kinesin-like protein KIF20A [KO:K10402]
108792139  KIF20B; kinesin-like protein KIF20B [KO:K10402]
108797602  KIF20A; kinesin-like protein KIF20A isoform X1 [KO:K10402]
108796034  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
108789052  CENPE; centromere-associated protein E [KO:K11498]
108796730  KIF18A; kinesin-like protein KIF18A [KO:K10401]
108796129  kinesin-like protein KIF18B [KO:K26156]
108786195  kinesin-like protein KIF19 [KO:K26157]
108796719  KIF19; kinesin-like protein KIF19 [KO:K26157]
108796016  kinesin-like protein KIF6 [KO:K10397]
108802338  KIF9; LOW QUALITY PROTEIN: kinesin-like protein KIF9 [KO:K10397]
108789163  KIF22; kinesin-like protein KIF22 [KO:K10403]
108787206  KIF26A; kinesin-like protein KIF26A [KO:K10404]
108787492  KIF26B; kinesin-like protein KIF26B [KO:K10404]
108796468  KIF15; kinesin-like protein KIF15 [KO:K10400]
108799178  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
108801433  KIF2C; kinesin-like protein KIF2C [KO:K10393]
108797450  KIF24; kinesin-like protein KIF24 [KO:K10393]
108788369  KIFC1; kinesin-like protein KIFC1 [KO:K10405]
108803664  kinesin-like protein KIFC3 [KO:K10406]
108804083  LOW QUALITY PROTEIN: kinesin-like protein KIFC3 [KO:K10406]
108787991  KIF25; kinesin-like protein KIF25 [KO:K18627]
108785995  MYO1D; unconventional myosin-Id [KO:K10356]
108787620  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
108795205  unconventional myosin-Ie-like [KO:K10356]
108797046  MYO1A; unconventional myosin-Ia [KO:K10356]
108801498  MYO1F; unconventional myosin-If [KO:K10356]
108801194  unconventional myosin-Ig-like isoform X1 [KO:K10356]
108793328  MYO1E; unconventional myosin-Ie [KO:K10356]
108801953  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
108790230  MYO1H; unconventional myosin-Ih [KO:K10356]
108785482  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
108788212  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
108790686  MYO5B; unconventional myosin-Vb [KO:K10357]
108804209  MYO5C; unconventional myosin-Vc [KO:K10357]
108804358  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
108788997  MYO6; unconventional myosin-VI [KO:K10358]
108798050  MYO7A; unconventional myosin-VIIa [KO:K10359]
108792673  MYO7B; unconventional myosin-VIIb [KO:K21868]
108784048  MYO9A; unconventional myosin-IXa [KO:K10360]
108796701  MYO9B; unconventional myosin-IXb [KO:K10360]
108802877  unconventional myosin-X-like [KO:K12559]
108788634  MYO10; unconventional myosin-X [KO:K12559]
108797665  MYO15A; unconventional myosin-XV [KO:K10361]
108792384  MYO16; unconventional myosin-XVI [KO:K17481]
108792618  MYO18A; unconventional myosin-XVIIIa [KO:K10362]
108790267  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
108795726  MYO19; unconventional myosin-XIX [KO:K25838]
108784482  myosin-4-like isoform X1 [KO:K24220]
108784483  myosin-4-like isoform X1 [KO:K24220]
108788269  myosin-1B-like [KO:K24220]
108801086  myosin-1B-like [KO:K24220]
108801087  myosin-3-like isoform X1 [KO:K24220]
108803329  myosin-4-like [KO:K24220]
108803769  myosin-1B-like [KO:K24220]
108797488  MYH7B; myosin-7B [KO:K24220]
108794737  myosin-6-like [KO:K24220]
108786749  MYH7; myosin-7 [KO:K17751]
108786757  myosin-6 [KO:K17751]
108789546  myosin-10-like isoform X1 [KO:K10352]
108793304  MYH11; myosin-11 isoform X1 [KO:K10352]
108793694  MYH9; myosin-9 [KO:K10352]
108795684  MYH10; myosin-10 [KO:K10352]
108794422  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
108802637  MYL4; myosin light chain 4 [KO:K12750]
108790528  myosin light polypeptide 6-like isoform X1 [KO:K12751]
108788538  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108796071  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
108787984  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108801753  MYL10; myosin regulatory light chain 10 [KO:K12756]
108784895  myosin regulatory light chain RLC-A [KO:K12757]
108803796  LOW QUALITY PROTEIN: myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
108788870  ACTA2; actin, aortic smooth muscle [KO:K12313]
108800760  actin, alpha cardiac muscle 1 [KO:K12314]
108793897  actin, alpha cardiac muscle 1-like isoform X1 [KO:K12314]
108794424  actin, alpha cardiac muscle 1-like [KO:K12314]
108800042  actin, alpha cardiac muscle 2-like [KO:K12314]
108796718  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108799803  actin, cytoplasmic 1 [KO:K05692]
108793959  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
108794414  troponin C, slow skeletal and cardiac muscles [KO:K05865]
108792788  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
108792019  troponin I, slow skeletal muscle-like [KO:K10371]
108796750  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
108793376  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
108791994  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
108791992  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
108794936  TNNI3; troponin I, cardiac muscle [KO:K12044]
108804863  TNNT2; troponin T, cardiac muscle [KO:K12045]
108784053  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
108798807  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
108786385  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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