EGF-EGFR-RAS-ERK signaling pathway

Mutation-activated KRAS/NRAS to ERK signaling pathway

Mutation-activated BRAF to ERK signaling pathway

PTEN-PIP3-AKT signaling pathway

Deleted PTEN to PI3K signaling pathway

Mutation-inactivated PTEN to PI3K signaling pathway

EGF-EGFR-RAS-PI3K signaling pathway

Mutation-activated KRAS/NRAS to PI3K signaling pathway

MDM2-p21-Cell cycle G1/S

Deleted p14(ARF) to p21-cell cycle G1/S

Mutation-inactivated p14(ARF) to p21-cell cycle G1/S

p16-Cell cycle G1/S

Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S

Deleted p16(INK4a) to p16-cell cycle G1/S

Mutation-activated CDK4 to cell cycle G1/S

Mutation-inactivated TP53 to transcription