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ENTRY	nt06268
Name	Melanoma
Category	Disease view; Cancer
Pathway	hsa05218 Melanoma
Disease	H00038 Melanoma
Display	drug-target relation   disease type

N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1 N10007                        (Vemurafenib,Dabrafenib,Encorafenib) ⊥ N10008                            (Trametinib,Cobimetinib,Binimetinib) ⊥ N00013                        BRAF* → MEK → ERK   N00220    PTEN ⊣ PIP3 → AKT N00051    PTEN* ⌿ PIP3 → AKT N00052    PTEN* ⌿ PIP3 → AKT N00030    EGF → EGFR → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD N00032                    (KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD   N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00067    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00076    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00069                CDKN2A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00070                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00071                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00073                    (CCND+CDK4*) → RB1 ⌿ E2F   N00115    TP53* ⌿ (CDKN1A,GADD45,BAX..