Network variation - Melanoma
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ENTRY
nt06268
Name
Melanoma
Category
Disease view; Cancer
Pathway
hsa05218
Melanoma
Disease
H00038
Melanoma
Display
drug-target relation
disease type
N00001
EGF
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00012
(
KRAS*
,
NRAS*
)
→
RAF
→
MEK
→
ERK
→
CCND1
N10007
(Vemurafenib,Dabrafenib,Encorafenib)
⊥
N10008
(Trametinib,Cobimetinib,Binimetinib)
⊥
N00013
BRAF*
→
MEK
→
ERK
N00220
PTEN
⊣
PIP3
→
AKT
N00051
PTEN*
⌿
PIP3
→
AKT
N00052
PTEN*
⌿
PIP3
→
AKT
N00030
EGF
→
EGFR
→
GRB2
→
SOS
→
RAS
→
PI3K
→
PIP3
→
AKT
⊣
BAD
N00032
(
KRAS*
,
NRAS*
)
→
PI3K
→
PIP3
→
AKT
⊣
BAD
N00066
CDKN2A
⊣
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00067
CDKN2A*
⌿
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00076
CDKN2A*
⌿
MDM2
⊣
TP53
⇒
CDKN1A
⊣
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00069
CDKN2A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00070
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00071
CDKN2A*
⌿
(
CCND
+
CDK4/6
)
→
RB1
⌿
E2F
N00073
(
CCND
+
CDK4*
)
→
RB1
⌿
E2F
N00115
TP53*
⌿
(
CDKN1A
,
GADD45
,
BAX..